Letter from M. John Davis to M. Sanderson, 16th September 1587

Davis, John; Markham, Albert Hastings

doi:10.1017/cbo9780511697609.011

Cited by 44 publications

(80 citation statements)

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“…[150] Following acondensation copolymerization, ap olycationic polymer (CDP) with CD units in the backbone was formed from adifunctionalized b-CD monomer and ad ifunctional dimethylsuberimidate monomer.T he delivery vehicle was stabilized by adamantyl end functionalized PEG with (AD-PEG). Ah etero-bifunctional PEG (AD-PEG-Tf) with adamantyl groups and targeting ligand (human transferrin, Tf) was introduced to engage cell receptors and induce endocytosis.N anoparticle vectors with targeting ligands on the outside and siRNAinthe inside were formed by the addition of asolution of siRNAto the CDP components.N anoparticles with diameters of 60 to 80 nm were obtained and DNAzyme,p DNA, and siRNA delivery was investigated in vivo.Avery efficient delivery system was obtained that eventually went to clinical trials.…”

Section: Surface Modificationsmentioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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Dynamic and adaptive materials are powerful constructs in macromolecular and polymer chemistry with a wide array of applications in drug delivery, bioactive systems, and self‐healing materials. Very often, dynamic materials are based on carefully tailored cyclodextrin host–guest interactions. The precise incorporation of these host and guest moieties into macromolecular building blocks allows the formation of complex macromolecular structures with predefined functions. Thus, dynamic materials with extraordinary adaptive property profiles—responsive to thermal, chemical, and photonic fields—become accessible. This Review explores the hierarchical formation of dynamic materials and complex macromolecular structures from the molecular via the macromolecular to the colloidal and macroscopic level, with a specific emphasis on the functionality and responsiveness of the assemblies, specifically in biological contexts.

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Section: Surface Modificationsmentioning

confidence: 99%

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

2017

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“…The failure to detect very high levels of 25-OHD in the vitamin D group may be due to the inhibition of hepatic 25-hydroxylation by massive doses of vitamin D (5). In human pregnancy, hepatic microsomal enzymes might be induced which may further increase the metabolism of 25-OHD (8).…”

Section: Litter Size and Newborn Weightsmentioning

confidence: 99%

Effect of Vitamin D on Pregnant Rabbits and Their Offspring

et al. 1979

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SummaryThe morphologic and biochemical effects of vitamin D in pregnant rabbits and their offspring were studied. Four groups of four pregnant does were given 100,000 IU, 10,000 IU, and 1,000 IU vitamin Dz or placebo im during pregnancy. Prestudy serum Ca, P, 25-hydroxy vitamin D (25-OHD), and cholesterol levels were not different between the control and vitamin D-supplemented does. At midgestation, the vitamin D-supplemented dose had significantly higher serum Ca levels than did controls (16.4 f 0.6, mean k SE, vs. 15.3 f 0.4 &dl), higher serum P than control, (6.41 f 0.06 vs. 4.50 k 0.54 mg/dl), higher serum 25-OHD than controls (39 k 6 vs. 21 k 2 ng/ml), and higher serum cholesterol than controls (64.0 f 17.2 vs. 27.5 f 8.2 @dl, Wilcoxon rank, P < 0.05). At term, the vitamin D-supplemented does had significantly higher serum Ca than controls (15.2 f 0.6 vs. 12.3 f 0.10 mg/dl), higher serum P than controls (5.06 f 0.48 vs. 2.% f 0.55 mg/dl), and higher serum 25-OHD levels than controls (50 f 5 vs.35 +. 5 ng/ml, Wilcoxon rank, P < 0.05). Two maternal does from the 100,000 D group that had serum 25-OHD levels greater than 100 ng/ml developed aortic medical calcifications. The 100,000 vitamin D does had a significantly higher number of abortions, 6 of 26 pregnancies, compared with control, 0 of 27 pregnancies v, P < 0.01). In the newborns, only the 10,000 D group had higher serum ionized Ca, 6.21 -t 0.28 vs. 5.26 f 0.06 mg/dl in controls (Wilcoxon rank, P < 0.001). There were no significant differences in newborn 25-OHD and cholesterol levels among the four groups. Newborn aortic root showed supravalvular lesions in 2 of 11 newborns in the 10,000 D group (2, P < 0.05) and 6 of 20 newborns in the 100,000 D group v, P < 0.01) compared with no lesions in the controls (0 of 27). No supravalvular lesions were found in the 1,000 D group. Thus, high doses of vitamin D during pregnancy affect fetal death, maternal calcium and cholesterol homeostasis, neonatal calcium homeostasis, and cause calcific aortic lesions in the mother and an apparent dose-related development of supravalvular aortic lesions in the newborn. SpeculationMaternal vitamin D toxicity during pregnancy contributed to the development of supravalvular aortic lesions in the fetus which might lead to the infantile hypercalcemia syndrome. Vitamin D might have a direct toxic effect on maternal and fetal vascular areas of high turbulence flow.

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“…Verbal ratings were obtained on the Experiencing Scale (Klein, Mathieu, Gendlin, & Kiesler, 1970), and nonverbal ratings were obtained on the Davis Nonverbal States Scales (Davis, 1986). Results revealed that the position "accessibility" ratings were related significantly to levels of self-disclosure and involvement as determined by the verbal ratings.…”

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confidence: 99%

“…Some studies have utilized actors rather than real therapists (Fretz, Corn, Tuemmler, & Bellet, 1979; La Cross, 1975;Smith, 1972;Trout & Rosenfeld, 1980) and have relied on college students to evaluate complex constructs such as rapport (Dinges & Oetting, 1972; Karger, 1974; La Cross, 1975;Lassen, 1973). These "impression" studies have been criticized for the weakness of their external validity (Bakken, 1978; Davis, 1985; Gladstein, 1974;Myers & Myers, 1972). Wallbott (1985) has demonstrated that there are serious limitations to data based on judgments of patients' movements made by untrained observers.…”

mentioning

confidence: 99%

“…Wallbott (1985) has demonstrated that there are serious limitations to data based on judgments of patients' movements made by untrained observers. Other studies have measured single variables, such as amount of eye contact (Fretz et al, 1979) or interpersonal distance (Boucher, 1972;Lassen, 1973), in ways that are so simplistic that they generate naive, clinically trivial information (Davis, 1985).…”

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confidence: 99%

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Nonverbal behavior and client state changes during psychotherapy

Davis¹,

Hadiks

1990

J. Clin. Psychol.

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In an intensive videotape analysis of 10 psychotherapy sessions, the body positions and gesticulation patterns of the client were examined in relation to changes in her verbal behavior. Verbal ratings were obtained on the Experiencing Scale (Klein, Mathieu, Gendlin, & Kiesler, 1970), and nonverbal ratings were obtained on the Davis Nonverbal States Scales (Davis, 1986). Results revealed that the position “accessibility” ratings were related significantly to levels of self‐disclosure and involvement as determined by the verbal ratings. The client's gesticulation ratings were not related significantly to the Experiencing Scale ratings, but clinically interesting relationships between gesticulation patterns and verbal content were noted. While body movement long has been recognized as an important source of clinical information, replicable coding of complex patterns of position and gesture has been very difficult to develop. This study presents data that support a promising, replicable method for coding nonverbal behavior in psychotherapy process research.

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Letter from M. John Davis to M. Sanderson, 16th September 1587

Cited by 44 publications

References 0 publications

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Dynamic Macromolecular Material Design—The Versatility of Cyclodextrin‐Based Host–Guest Chemistry

Effect of Vitamin D on Pregnant Rabbits and Their Offspring

Nonverbal behavior and client state changes during psychotherapy

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