Letter: coeliac disease and small intestinal bacterial overgrowth ‐ is dysmotility the missing link?

Small intestinal bacterial overgrowth and celiac disease: A systematic review with pooled‐data analysis

“…If we consider the only three studies where a control group of non‐celiac subjects was enrolled, the mean prevalence of SIBO in CD was 20.9% vs the 18.1% in the control group, not statistically different with a P value of .09, and an OR of 1.61 (95% CI 0.93‐2.8). However, considering that the study by Mooney et al . enrolled symptomatic controls, its exclusion (ie, the comparison between CD and asymptomatic controls) showed that CD is associated to higher risk of SIBO than controls, with an OR of 10.52 (95% CI 2.69‐41.21, P =.0007).…”

“…The literature search found 2053 articles overall. After the revision process, reported more in detail in Figure , only 11 articles fulfilled the criteria considered for our analysis …”

“…In total, 614 patients with CD were enrolled. Only three studies enclosed a control group of non‐celiac subjects. Moreover, in three of 11 studies, the diagnosis of SIBO was obtained by jejunal aspirate culture, whereas in others the lactulose or glucose BT was performed.…”

“…Moreover, in three of 11 studies, the diagnosis of SIBO was obtained by jejunal aspirate culture, whereas in others the lactulose or glucose BT was performed. Only one study reported the values of fasting hydrogen breath excretion, showing that levels were similar between CD and controls (7 vs 8 ppm, P =.34). Patients with persistent symptoms despite GFD were considered in six studies .…”

“…After the revision process, reported more in detail in Figure 1, only 11 articles fulfilled the criteria considered for our analysis. 10,[19][20][21][22][23][24][25][26][27][28] In total, 614 patients with CD were enrolled. Only three studies 22,27,28 enclosed a control group of non-celiac subjects.…”