“…[20][21][22][23] In 2018, the American Heart Association recommended a "radial-first" strategy in the United States for patients with acute coronary syndromes. 24 Early observational studies and the more recent ACCOAST study suggested a higher frequency of stroke with TRA, 25,26 though the aforementioned meta-analyses also examined more recent rates of stroke and found no statistical difference. [21][22][23] The data from these analyses, however, were not granular or well powered.…”