Abstract:We would like to congratulate Pfeffer et al 1 for their excellent review of the current state of knowledge of the complex syndrome of heart failure with preserved ejection fraction (HFpEF). The authors provide a comprehensive historical and epidemiological perspective on the evolution in our understanding of this syndrome. However, we would like to point out that there is a fundamental pathophysiological process supported by animal and human data that should be included when considering this disorder. In parti… Show more
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