Letter: Altered Motor Excitability in Patients With Diffuse Gliomas Involving Motor Eloquent Areas: The Impact of Tumor Grading

Santos, Alexandra Gomes dos; Hayashi, Cintya Yukie; Almeida, Cesar Cimonari de; Paiva, Wellingson Silva; Andrade, Daniel Ciampi de; Galhardoni, Ricardo; Brunoni, André R.; Teixeira, Manoel Jacobsen; Neville, Iuri Santana

doi:10.1093/neuros/nyaa512

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…This study sums to the current knowledge of brain plasticity in the context of brain tumors involving the primary motor cortex by evaluating graphic cortical maps representations already reported, as well as describing adjusted quantitative parameters as rRMT and, introducing ratio values of ΔL, SDpc, VCpc as possible markers of brain plasticity. The use of the normalized ratios was to our knowledge a novelty, and despite masking the qualitative evaluation of the absolute parameters, allows for a better interpatient comparison, mitigating previous dissonances in literature, such as reports of both higher and lower RMT ratios in the similar groups of glioma patients ( Lavrador et al, 2020 ; Gomes dos Santos et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Quantification of tumor induced motor cortical plasticity using navigated transcranial magnetic stimulation in patients with adult-type diffuse gliomas

et al. 2023

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IntroductionThe evaluation of brain plasticity can provide relevant information for the surgical planning of patients with brain tumors, especially when it comes to intrinsic lesions such as gliomas. Neuronavigated transcranial magnetic stimulation (nTMS) is a non-invasive tool capable of providing information about the functional map of the cerebral cortex. Although nTMS presents a good correlation with invasive intraoperative techniques, the measurement of plasticity still needs standardization. The present study evaluated objective and graphic parameters in the quantification and qualification of brain plasticity in adult patients with gliomas in the vicinity of the motor area.MethodsThis is a prospective observational study that included 35 patients with a radiological diagnosis of glioma who underwent standard surgical treatment. nTMS was performed with a focus on the motor area of the upper limbs in both the affected and healthy cerebral hemispheres in all patients to obtain data on motor thresholds (MT) and graphical evaluation by three-dimensional reconstruction and mathematical analysis of parameters related to the location and displacement of the motor centers of gravity (ΔL), dispersion (SDpc) and variability (VCpc) of the points where there was a positive motor response. Data were compared according to the ratios between the hemispheres of each patient and stratified according to the final pathology diagnosis.ResultsThe final sample consisted of 14 patients with a radiological diagnosis of low-grade glioma (LGG), of which 11 were consistent with the final pathology diagnosis. The normalized interhemispheric ratios of ΔL, SDpc, VCpc, and MT were significantly relevant for the quantification of plasticity (p < 0.001). The graphic reconstruction allows the qualitative evaluation of this plasticity.ConclusionThe nTMS was able to quantitatively and qualitatively demonstrate the occurrence of brain plasticity induced by an intrinsic brain tumor. The graphic evaluation allowed the observation of useful characteristics for the operative planning, while the mathematical analysis made it possible to quantify the magnitude of the plasticity.

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Section: Discussionmentioning

confidence: 99%

Quantification of tumor induced motor cortical plasticity using navigated transcranial magnetic stimulation in patients with adult-type diffuse gliomas

et al. 2023

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“…Motor evoked potential (MEP) amplitude will be measured peak-to-peak and averaged across 30 consecutive MEPs. Our group previously used the same paradigm in other populations, including those with a high risk of seizures, such as brain tumors and schizophrenia, without any seizures being induced ( Gordon et al, 2019 ; dos Santos et al, 2021 ). Patients will then receive a single iTBS session over the left-hand muscle “hotspot” with the same parameters as those used for iTBS treatment.…”

Section: Methodsmentioning

confidence: 99%

Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: Study protocol for a randomized, double-blind, controlled trial

Valiengo

Pinto

Marinho

et al. 2022

Front. Hum. Neurosci.

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IntroductionTranscranial magnetic stimulation (TMS) is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation (TBS) is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate the efficacy of TBS in geriatric depression.Clinical trial registration[https://clinicaltrials.gov/ct2/], identifier [NCT04842929].

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In Reply: Altered Motor Excitability in Patients With Diffuse Gliomas Involving Motor Eloquent Areas: The Impact of Tumor Grading

Lavrador¹,

Gioti²,

Hoppe³

et al. 2021

Neurosurg.

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Letter: Altered Motor Excitability in Patients With Diffuse Gliomas Involving Motor Eloquent Areas: The Impact of Tumor Grading

Cited by 3 publications

References 9 publications

Quantification of tumor induced motor cortical plasticity using navigated transcranial magnetic stimulation in patients with adult-type diffuse gliomas

Quantification of tumor induced motor cortical plasticity using navigated transcranial magnetic stimulation in patients with adult-type diffuse gliomas

Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: Study protocol for a randomized, double-blind, controlled trial

In Reply: Altered Motor Excitability in Patients With Diffuse Gliomas Involving Motor Eloquent Areas: The Impact of Tumor Grading

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