Letter: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation

Rahman, Sabrina; Rahman, Moshiur; Moscote-Salazar, Luis Rafael; Lozada-Martínez, Iván David; Al-Salihi, Mohammed Maan

doi:10.1227/neu.0000000000001771

Cited by 2 publications

(4 citation statements)

References 12 publications

(15 reference statements)

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“…As stated in our article 2 and as mentioned in the commentary from Rahman et al, 1 DBS is being increasingly used for various neurological disorders and has made a large impact in the field of motor disorders. We agree that the neural underpinnings of psychiatric disorders have been elusive, in comparison with the strides made in the field of movement disorders.…”

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confidence: 62%

“…It is of course important that this care is overseen within the confines of rigorous ethical standards as we have done in our existing clinical trial and as stated in our original article. We once again thank Rahman et al 1 for their interest in this article.…”

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confidence: 90%

“…We thank the authors 1 for their thoughtful comments and agree that there is immense potential for implementing neuromodulation techniques such as deep brain stimulation (DBS) for neurological and neuropsychiatric disorders while taking into account its limitations and ethical considerations.…”

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confidence: 99%

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In Reply: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation

Allawala

Sheth

2021

Neurosurgery

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To the Editor:We thank the authors 1 for their thoughtful comments and agree that there is immense potential for implementing neuromodulation techniques such as deep brain stimulation (DBS) for neurological and neuropsychiatric disorders while taking into account its limitations and ethical considerations.As stated in our article 2 and as mentioned in the commentary from Rahman et al, 1 DBS is being increasingly used for various neurological disorders and has made a large impact in the field of motor disorders. We agree that the neural underpinnings of psychiatric disorders have been elusive, in comparison with the strides made in the field of movement disorders. This lack of understanding of network physiology underlying mental health disorders and its response to DBS is a driving force behind our proposal of adapting the epilepsy monitoring experience for refractory psychiatric and neurological disorders.Although the adaptation of such a neurophysiological monitoring unit has immense potential to help uncover dysfunctional networks, we agree that extreme care should be taken when offering these surgical therapies. It is critical that these innovative approaches be delivered by multidisciplinary teams with expertise across psychiatry, psychology, neurology, neuropsychiatry, and neurosurgery. It is of course important that this care is overseen within the confines of rigorous ethical standards as we have done in our existing clinical trial and as stated in our original article. We once again thank Rahman et al 1 for their interest in this article.

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confidence: 62%

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confidence: 90%

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In Reply: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation

Allawala

Sheth

2021

Neurosurgery

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“…32,33 As use of DBS for the treatment of Parkinson's disease increased, investigations into its use for the treatment of psychiatric diseases followed closely behind in incremental but meaningful steps. Currently, DBS is being investigated for the treatment of numerous neuropsychiatric conditions, 34,35 although the only neuropsychiatric condition to date to receive FDA humanitarian exemption status is severe, refractory OCD. 36 To disrupt the cortico-striato-thalamo-cortical circuit, which is thought to be overactive in OCD, several anatomical sites have been targeted with high-frequency stimulation with favorable results, including the ventral capsule/ ventral striatum (VC/VS), nucleus accumbens (NAc), and inferior thalamic peduncle.…”

Section: Deep Brain Stimulation and Modern Usesmentioning

confidence: 99%

Neurosurgery for psychiatric disorders: reviewing the past and charting the future

Bauerle

Palmer

Salazar

et al. 2023

Neurosurgical Focus

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Surgical techniques targeting behavioral disorders date back thousands of years. In this review, the authors discuss the history of neurosurgery for psychiatric disorders, starting with trephination in the Stone Age, progressing through the fraught practice of prefrontal lobotomy, and ending with modern neurosurgical techniques for treating psychiatric conditions, including ablative procedures, conventional deep brain stimulation, and closed-loop neurostimulation. Despite a tumultuous past, psychiatric neurosurgery is on the cusp of becoming a transformative therapy for patients with psychiatric dysfunction, with an ever-increasing evidence base suggesting reproducible and ethical therapeutic benefit.

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Letter: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation

Cited by 2 publications

References 12 publications

In Reply: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation

In Reply: A Novel Framework for Network-Targeted Neuropsychiatric Deep Brain Stimulation

Neurosurgery for psychiatric disorders: reviewing the past and charting the future

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