Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease

Kisspeptin mRNA expression is increased in the posterior hypothalamus in the rat model of polycystic ovary syndrome

“…Serum FSH was not significantly different between the groups. These findings were identical as previous reports [11][12][13].…”

“…The corpus luteum and follicle growth in each stage were observed in the control group. These findings were identical as previous reports [11][12][13]. Effect of letrozole on the serum steroid concentrations Serum LH and T concentrations of the letrozole group were significantly higher than those of the control group (p<0.05 for both) (Fig.…”

“…The analytical sensitivity of LH and FSH assays were 0.1 mUI/mL and 0.1 mUI/mL, respectively, and intra-assays of LH and FSH were 6.5% and abnormality but does display metabolic features of PCOS [10]. However, the rat model induced by letrozole, a non-steroidal aromatase inhibitor, shows elevated LH and T levels, anovulation, absence of corpus luteum, hyperplasia of the theca cell layer, diminished granulosa cells and increased ovarian size, which are similar findings to human PCOS [11][12][13]. Therefore, the letrozole-induced PCOS model rat may be suitable for study of the mechanism of anovulation, including hypersecretion of LH originated from the hypothalamus, which cannot be tested in the hypothalamus of human PCOS.…”

Histologic comparison of polycystic ovary syndrome induced by estradiol valerate and letrozole

“…그러나 최근 LE를 이용하여 21일 후 PCOS를 성공적으로 유발할 수 있다는 보고가 있다 [12]. EV는 1회 근육주사 후 60일째 [5,6,11], LE 는 21일간 경구투여 후 [12] (Table 1). …”

Effect of Combined Treatment of Modern and Herbal Supplement in the Management of Letrozole Induced Polycystic Ovary Syndrome

“…As granulosa cells convert androgen to estradiol with the help of the aromatase enzyme. As already discussed that letrozole is a aromatase inhibitor, thus administration of letrozole, increased the concentration of androgen, which may be the cause of increased number of atretic follicles in ovary [26]. Detachment of granulosa cells is one of the morphological characteristic features of follicular atresia.…”