Letrozole as an adjunct treatment in antagonist cycles that previously failed in poor responders

Kaçar, Melek Turaç; Biler, Alper; Köse, Can; Güleç, Ebru Şahin; Demir, Ahmet

doi:10.5603/gp.a2021.0116

Cited by 1 publication

(1 citation statement)

References 26 publications

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“…Letrozole is a highly selective, non-steroidal aromatase inhibitor. It prevents estrogen syntheses by inhibiting the aromatase enzyme activity, thus increasing the expression of FSH receptors on the follicle (61). Letrozole administration could improve pregnancy rates in conventional GnRH antagonist protocols, as demonstrated in a recent meta-analysis by Qin et al in 2021 (62).…”

Section: Letrozolementioning

confidence: 99%

Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review

Galatis

Kalopita

Grypiotis

et al. 2022

ama

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This narrative review aims to summarize all the latest studies published between 2015-2021 concerning the management protocols adopted for poor ovarian response (POR) cases. Patients defined as “poor responders” show minimal response to controlled ovarian hyperstimulation, although there is no standard definition for POR. Although infertility specialists are endeavoring to improve cycle outcomes in poor responders by adopting multiple management strategies, still the estimated risk of cycle cancellation is about 20%. All the studies performed during this study period were evaluated and their results were recorded. The latest published protocols to improve oocyte retrieval in poor responders include: anti-Mϋllerian hormone, clomiphene citrate, co-enzyme Q10, corifollitropin, dehydroepiandrosterone, double stimulation, Follicle Stimulation Hormone, Growth Hormone, Gonadotropin-releasing hormone agonists, letrozole, human chorionic gonadotropin, Luteinizing Hormone, progesterone and testosterone. Conclusion. Although many strategies have been suggested to manage POR, none has been proven superior to the others. Further large-scale randomized studies are needed to validate experimental techniques leading towards successful individualized treatment regimens.

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Section: Letrozolementioning

confidence: 99%

Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review

Galatis

Kalopita

Grypiotis

et al. 2022

ama

View full text Add to dashboard Cite

show abstract

Letrozole as an adjunct treatment in antagonist cycles that previously failed in poor responders

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 1 publication

References 26 publications

Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review

Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review

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