Lethal Thrombosis during Coronary Artery Bypass Graft Surgery

Litwack, Robert S.; Horrow, Jan C.

doi:10.1097/00000542-198707000-00031

Cited by 2 publications

(1 citation statement)

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“…Since no more than five to seven daily doses are recommended, adverse effects due to oestrogenic hormonal activity are usually avoided. However, in a case report by Litwack and Horrow, 88 the authors thought that the use of conjugated oestrogens might have contributed to the development of fatal occlusion of all saphenous vein grafts after coronary artery bypass grafting. In general, the role of conjugated oestrogens in perioperative haemostasis is limited and at best not well investigated.…”

Section: Conjugated Oestrogensmentioning

confidence: 99%

Perioperative systemic haemostatic agents

Mahdy

Webster

2004

British Journal of Anaesthesia

154

117

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Skilful surgery combined with blood-saving methods and careful management of blood coagulation will all help reduce unnecessary blood loss and transfusion requirements. Excessive surgical bleeding causes hypovolaemia, haemodynamic instability, anaemia and reduced oxygen delivery to tissues, with a subsequent increase in postoperative morbidity and mortality. The role of anaesthetists in managing surgical blood loss has increased greatly in the last decade. Position of the patient during surgery and the provision of a hypotensive anaesthetic regimen were once considered the most important contributions of the anaesthetist to decreasing blood loss. Now, several pharmacological haemostatic agents are being used by anaesthetists as blood-saving agents. After a brief discussion of the physiology of haemostasis, this article will review the evidence for the role of such agents in reducing perioperative blood loss and transfusion requirements.

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Section: Conjugated Oestrogensmentioning

confidence: 99%