Lethal metabolism of Candida albicans respiratory mutants
D. Lucas Kane,
Brendan Burke,
Monica Diaz
et al.
Abstract:The destructive impact of fungi in agriculture and animal and human health, coincident with increases in antifungal resistance, underscores the need for new and alternative drug targets to counteract these trends. Cellular metabolism relies on many intermediates with intrinsic toxicity and promiscuous enzymatic activity generates others. Fuller knowledge of these toxic entities and their generation may offer opportunities of antifungal development. From this perspective our observation of media-conditional let… Show more
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