Lethal Giant Larvae Controls the Localization of Notch-Signaling Regulators Numb, Neuralized, and Sanpodo in Drosophila Sensory-Organ Precursor Cells

Langevin, Johanna; Borgne, Roland Le; Rosenfeld, François; Gho, Michel; Schweisguth, François; Bellaı̈che, Yohanns

doi:10.1016/j.cub.2005.04.054

Cited by 104 publications

(113 citation statements)

References 30 publications

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“…In Drosophila neuroblasts of the SOPs, Lgl is important in the asymmetric distribution of Numb (Betschinger et al, 2003;Wirtz-Peitz et al, 2008), an inhibitor of Notch signalling. Indeed, SOP cells have ectopic Notch signalling (Langevin et al, 2005;Roegiers et al, 2005). Similarly, the neural tube of lgl1 À/À mice displays hyperplasia that is associated with increased Notch signalling (Klezovitch et al, 2004).…”

Section: Scribble/dlg/lgl and Other Polarity Complexesmentioning

confidence: 99%

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

et al. 2008

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The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the vinegar fly Drosophila melanogaster, are currently being actively studied for their potential role in mammalian tumourigenesis. In Drosophila, these tumour suppressors function in a common genetic pathway to regulate apicobasal cell polarity and also play important roles in the control of cell proliferation, survival, differentiation and in cell migration/invasion. The precise mechanism by which Scribble, Dlg and Lgl function is not clear; however, they have been implicated in the regulation of signalling pathways, vesicle trafficking and in the Myosin II-actin cytoskeleton. We review the evidence for the involvement of Scribble, Dlg, and Lgl in cancer, and how the various functions ascribed to these tumour suppressors in Drosophila and mammalian systems may impact on the process of tumourigenesis.

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Section: Scribble/dlg/lgl and Other Polarity Complexesmentioning

confidence: 99%

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

et al. 2008

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“…Mouse mutants lacking the mammalian form of Lgl, a protein linked to Numb distribution in Drosophila (Langevin et al 2005), develop structures similar to primitive neuroectodermal tumors and severe hydrocephalus, and die neonatally (Klezovitch et al 2004). The vast majority of Lgl1 −/− progenitors fail to distribute the Numb polarity protein asymmetrically and undergo hyper-proliferation, resulting in "cortical dysplasia."…”

Section: Polarity Proteins In Neurogenesismentioning

confidence: 99%

Neuronal polarity in CNS development

Solecki¹,

Govek²,

Tomoda³

et al. 2006

Genes Dev.

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The diversity of neuronal morphologies and the complexity of synaptic connections in the mammalian brain provide striking examples of cell polarity. Over the past decade, the identification of the PAR (for partitioningdefective) proteins, their function in polarity in the Caenorhabditis elegans zygote, and the conservation of polarity proteins related to the PAR polarity complex in Drosophila and vertebrates, kindled intense interest in polarity pathways. Although the existence of a conserved polarity protein complex does not prove that these proteins function the same way in different systems, the emergence of an evolutionarily conserved mechanism that regulates cell polarity provides an exciting opportunity to define the role of polarity proteins in the generation of the diverse array of cell types and patterns of connections in the developing mammalian brain. This review addresses emerging genetic, molecular genetic, biochemical, and cell biological approaches and mechanisms that control neuronal polarity, focusing on recent studies using the neonatal cerebellum and hippocampus as model systems.The Caenorhabditis elegans embryo is a model system for studying cell polarity. Three PAR (for partitioningdefective) polarity proteins localize in the anterior cortex of the one-cell embryo: PAR-3, which contains three PDZ domains; PAR-6, which contains a single PDZ domain and a G-protein-binding, CRIB-like domain; and PKC-3, an atypical protein kinase C (abbreviated as aPKC, PKC). In Drosophila, homologs of the C. elegans PAR proteins are essential for the emergence of cellularity, and for asymmetric division of neuroblasts ( Many features of intercellular junctions are conserved across species from yeast to vertebrates. The apical junction in yeast shares common features with the Drosophila zonula adherens (ZA) junction and ZA junctions of mammalian epithelia, including a band of actin, the transmembrane adhesion proteins, and associated cytoplasmic proteins such as ␤-catenin. Polarity proteins that establish the polarity of intercellular junctions of Drosophila epithelia are related to vertebrate polarity proteins that generate intercellular junctions in increasingly complex, multilayered vertebrate epithelia (Fig. 1). In mammalian epithelia, the first step in epithelial cell polarization is the formation of adhesion junctions between cells. Two classes of transmembrane adhesion proteins, cadherins and nectins, initiate adhesions between epithelial cells. Aggregation of adhesion sites leads to the recruitment of cytoskeletal proteins; the association of the intracellular domains of cadherins and nectin activates the Cdc42 and Rac GTPase pathways. After the adherens junction forms, a second adhesion site forms at the apical side of the cell, which becomes a tight junction. In polarized mammalian epithelial cells, the conserved polarity proteins PAR-3/ASIP, PAR-6, and aPKC localize to the tight junction. Recent studies suggest that Par3 and Par6/aPKC form complexes with other polarity proteins as well (Gao and Macara...

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“…Spdo, a fourpass transmembrane protein involved in N signaling in Drosophila, is regulated by endocytosis in the SOPs (20,24,(45)(46)(47). Quantification of cortical versus cytoplasmic signals of Spdo showed that in wild-type NBs, Spdo was primarily cytoplasmic at metaphase, and it displayed weak cortical localization in the NB but not IPs at telophase ( Fig.…”

Section: Inactivation Of Ap-2 Complex Subunits Resulted In Ectopicmentioning

confidence: 99%

Interaction of Notch Signaling Modulator Numb with α-Adaptin Regulates Endocytosis of Notch Pathway Components and Cell Fate Determination of Neural Stem Cells

Song

2012

Journal of Biological Chemistry

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Lethal Giant Larvae Controls the Localization of Notch-Signaling Regulators Numb, Neuralized, and Sanpodo in Drosophila Sensory-Organ Precursor Cells

Cited by 104 publications

References 30 publications

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

Neuronal polarity in CNS development

Interaction of Notch Signaling Modulator Numb with α-Adaptin Regulates Endocytosis of Notch Pathway Components and Cell Fate Determination of Neural Stem Cells

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