Lethal efficacy of extract fromZingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol inAnisakis larvae in vitro

Goto, Chitoshi; Kasuya, Shiro; Koga, Kaori; Ohtomo, Hiroshi; Kagei, N.

doi:10.1007/bf00931082

Cited by 69 publications

(36 citation statements)

References 8 publications

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“…Traditional system of healing from parasitic diseases has been in use with variable success since ancient times and some traditional potions are still used world wide (Dhar et al, 1968;Didier et al, 1988;Goto et al, 1990;Kar et al, 2004;Robinson et al, 1990;Singh et al, 1982;Soh et al, 1980). Lushai people in Mizoram, a north-east state of India, traditionally consume Millettia pachycarpa, a leguminous climbing plant, (Family: Leguminosae) to get rid of suspected intestinal helminth infections.…”

Section: Introductionmentioning

confidence: 97%

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Roy

Dasgupta

Tandon

2008

Microscopy Res & Technique

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Millettia pachycarpa Benth (Leguminosae) has a usage in traditional medicine system practiced among the Lushai tribes of Mizoram, a state in North East India, who customarily consume the aqueous extract of the root peel of the plant to get rid of intestinal worm infections. The crude ethanol, methanol, and acetone fractions of the plant were assayed against Raillietina echinobothrida, the intestinal cestode parasite of domestic fowl, to authenticate the putative anthelmintic efficacy and cestocidal potential in particular of the plants. In vitro exposure of the worm to the extract at a concentration of 25 mg/mL phosphate buffered saline (at 37 degrees C +/- 1 degrees C) revealed distortion and disruption of mitochondria, nucleus, nucleolus, nuclear membrane, basal lamina, and tegumental vacuolization in the distal cytoplasm leading to scar formation in the surface. The possible use of the plant as a potential anthelmintic against cestode parasite is discussed.

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Section: Introductionmentioning

confidence: 97%

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Roy

Dasgupta

Tandon

2008

Microscopy Res & Technique

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“…Any disruption of the tegumental architecture is likely to have serious consequences on the worm. Synthetic anthelmintics have remained the drug of choice against cestodes but considering the side-effects and resistance that the helminths build against these drugs, more attention is being given to naturally-occurring anthelmintic phytoproducts (Goto et al 1990;Roy and Tandon 1996;Tandon et al 1997;Roy and Tandon 1999;Singh and Nagaich 1999). Acacia spp.…”

Section: Introductionmentioning

confidence: 99%

Antiparasitic activity of methanolic extract of Acacia oxyphylla (Leguminosae) against Raillietina echinobothrida

Dasgupta

Roy

2010

J Parasit Dis

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Acacia oxyphylla has been used traditionally by the natives of Mizoram against intestinal worm infections. In the present study, the crude methanolic extract of the plant was tested in vitro on the cestode parasite Raillietina echinobothrida to evaluate its potential anthelmintic efficacy. The test parasites were exposed to varying concentrations of the plant extract in phosphate buffered saline and they all slipped into a flaccid paralytic state at varying periods of time post incubation. Ultrastructural observations on the paralysed worms revealed wide scale destruction of the parasite tegument with intense vacuolization of the syncytium and swellings of the basal lamina accompanied by deformities in the cell organelles. To determine the exact mode of action of the botanicals on the parasite body surface, the tegumental enzymes viz. acid phosphatase (AcPase), alkaline phosphatase (AlkPase) and adenosine triphosphatase (ATPase) were investigated. A prominent decrease in the phosphatase activity, in comparison to the untreated control parasites was noticeable. In view of the alterations in the structural and functional integrity of the tegument, occurring in the treated parasites, it may be assumed that the changes transpire because of a compromise in the permeability of the tegument under the influence of the test plant-derived active chemical principles.

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“…that perilla leaves (Perilla frutescens) and ginger rhizomes (Zingiber officinale) are lethal for L3 (106).…”

mentioning

confidence: 99%

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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SUMMARY Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites (“gastroallergic anisakiasis”), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive.

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Lethal efficacy of extract fromZingiber officinale (traditional Chinese medicine) or [6]-shogaol and [6]-gingerol inAnisakis larvae in vitro

Cited by 69 publications

References 8 publications

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Ultrastructural observations on tegumental surface of Raillietina echinobothrida and its alterations caused by root‐peel extract of Millettia pachycarpa

Antiparasitic activity of methanolic extract of Acacia oxyphylla (Leguminosae) against Raillietina echinobothrida

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

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