2006
DOI: 10.1016/j.atherosclerosis.2005.08.014
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Lethal and severe coronary arteritis in DBA/2 mice induced by fungal pathogen, CAWS, Candida albicans water-soluble fraction

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Cited by 48 publications
(52 citation statements)
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“…The presence of Candida sequences is intriguing in light of murine models of coronary arteritis based on exposure to Candida glucans comprising mannose, β-1,3-glucan and β-1,6-glucan. Vulnerability to disease varies by mouse strain and is associated with elevated levels of IL-6, TNF-α, and IFN-γ (21,22). Similar to KD, vasculitis can be abrogated by use of i.v.…”
Section: Resultsmentioning
confidence: 99%
“…The presence of Candida sequences is intriguing in light of murine models of coronary arteritis based on exposure to Candida glucans comprising mannose, β-1,3-glucan and β-1,6-glucan. Vulnerability to disease varies by mouse strain and is associated with elevated levels of IL-6, TNF-α, and IFN-γ (21,22). Similar to KD, vasculitis can be abrogated by use of i.v.…”
Section: Resultsmentioning
confidence: 99%
“…1 and 2). Analysis of serial sections of the aorta stained with H&E suggested that the vasculitis in CBA/N mice was mild compared with that in DBA/2 mice, because aortic stenosis was mild and no reduction in survival rate was observe after CAWS administration (10,14). Previous studies have shown that elastic fiber injury occurs in the aorta close to the beginning of the coronary artery in mice that develop CAWS-vasculitis (10).…”
Section: Discussionmentioning
confidence: 95%
“…[7][8][9][10][11][12] An acute lethal reaction occurred within 1 h after the i.v. administration of CAWS to mice, in the form of anaphylactic shock.…”
Section: Discussionmentioning
confidence: 99%
“…CAWS was found to be composed of a mannoprotein-b-glucan complex, to be able to activate limulus G factor, 6) to demonstrate an activating effect on vascular endothelial cells, platelets, and lymphocytes, and to demonstrate vasculitis-inducing activity when administered to mice. [7][8][9][10][11] Moreover, CAWS caused an acute lethal reaction when administered intravenously to mice. The vasculitis was strongly related to the structure of the mannan moiety, and the activity was significantly reduced in the presence of a beta-1,2-linked mannosyl segment which was synthesized under specific conditions.…”
mentioning
confidence: 99%