Let7a involves in neural stem cell differentiation relating with TLX level

Song, Jeong Sup; Cho, Kyoung Joo; Oh, Yumi; Lee, Jong Eun

doi:10.1016/j.bbrc.2015.05.004

Cited by 18 publications

(9 citation statements)

References 34 publications

(32 reference statements)

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“…Further study with animal model is needed to elucidate the role of miR-Let7A in brain endothelial system under hyperglycemic condition. Second, this study used nontreated cells and high glucose-treated cells as “control” based on the previous reports [16, 21–24], but using control mimic (i.e., C. elegans miR-2 or any other unrelated miR) in the control cells would be meaningful to elucidate the sole effect of miR-Let7A on brain endothelial cells in the future.…”

Section: Discussionmentioning

confidence: 99%

miR‐Let7A Controls the Cell Death and Tight Junction Density of Brain Endothelial Cells under High Glucose Condition

Song

Yoon

Kim

2017

Oxidative Medicine and Cellular Longevity

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Hyperglycemia-induced stress in the brain of patients with diabetes triggers the disruption of blood-brain barrier (BBB), leading to diverse neurological diseases including stroke and dementia. Recently, the role of microRNA becomes an interest in the research for deciphering the mechanism of brain endothelial cell damage under hyperglycemia. Therefore, we investigated whether mircoRNA Let7A (miR-Let7A) controls the damage of brain endothelial (bEnd.3) cells against high glucose condition. Cell viability, cell death marker expressions (p-53, Bax, and cleaved poly ADP-ribose polymerase), the loss of tight junction proteins (ZO-1 and claudin-5), proinflammatory response (interleukin-6, tumor necrosis factor-α), inducible nitric oxide synthase, and nitrite production were confirmed using MTT, reverse transcription-PCR, quantitative-PCR, Western blotting, immunofluorescence, and Griess reagent assay. miR-Let7A overexpression significantly prevented cell death and loss of tight junction proteins and attenuated proinflammatory response and nitrite production in the bEnd.3 cells under high glucose condition. Taken together, we suggest that miR-Let7A may attenuate brain endothelial cell damage by controlling cell death signaling, loss of tight junction proteins, and proinflammatory response against high glucose stress. In the future, the manipulation of miR-Let7A may be a novel solution in controlling BBB disruption which leads to the central nervous system diseases.

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Section: Discussionmentioning

confidence: 99%

miR‐Let7A Controls the Cell Death and Tight Junction Density of Brain Endothelial Cells under High Glucose Condition

Song

Yoon

Kim

2017

Oxidative Medicine and Cellular Longevity

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“…Recently it was shown that miRNA lethal-7b (let-7b) also regulates the decision of the fate of neural stem cells [ 98 ]. Overexpression of let-7b led to the inhibition of proliferation of neural stem cells and accelerated neuronal differentiation, whereas the antisense drop of let-7b resulted in an increased proliferation of neural stem cells.…”

Section: Regulation Of Micrornasmentioning

confidence: 99%

Cell Signaling in Neuronal Stem Cells

Quiroz

Ahmad

et al. 2018

Cells

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The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS). A strict temporal space control of the NSC differentiation is necessary, because its alterations are associated with neurological dysfunctions and, in some cases, death. This work reviews the current state of the molecular mechanisms that regulate the transcription in NSCs, organized according to whether the origin of the stimulus that triggers the molecular cascade in the CNS is internal (intrinsic factors) or whether it is the result of the microenvironment that surrounds the CNS (extrinsic factors).

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“…This gene product is also contributed in regulating axonal growth and synaptic connectivity leading to gain an adequate of the central nervous system CNS Cariboni et al, (6). Moreover, Song et al, (28) demonstrated that T-cell leukemia translocation, also known as Hox11 (TLX) is considered as an important target in neural development through the progressive regulation of cell cycle in Neural Stem Cells (NSCs). Modern poultry production is generally aimed at elevation of egg production and inhibition of incubation behavior Xu et al, (31).…”

Section: Introductionmentioning

confidence: 99%

Three Candidate Genes and Its Association With Quantitative Variation of Egg Production Traites of Local Quail by Using PCR-RFLP

Ahmed¹

2020

Iraqi J. Agric. Sci.

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The aim of study was to investigate the potential candidate gene SEMA3E, TLX and GH and their association with the economic traits, which is becoming increasingly important in poultry breeding program. A total of 72 genomic DNA samples from three female local lines of quail including (desert, brown and white) were collected to determine the association of genes with reproduction trait using PCR-RFLP Technique. According to growth performance the Best Linear Unbiased Prediction (BLUP) value in selected females for high (H) and low (L) production traits was ranged from -9.2173 to 0.3827. This value is used to estimate body weight at first egg (BWFE), age at first egg (AFE), weight at first egg (WFE), Egg number per Bird (ENPH), Average egg weight (EWTA), and hen day (HD) in three lines. The results indicate that there was a wide intra specific SEMA3E, TLX and GH variability among these local quails which identifying twelve differences genotypes. The identified genotypes for all genes had a significantly (P<0.05) affected on the reproduction trait during first 150 days. The quail’s genotype AAABAA always exhibited the largest body weight at first egg in desert H line, while L line of white was greater in Egg number per bird and hen day of the genotype ACCCAC. No significant associations were observed between all loci and age at first egg trait among local quails. The results indicate that there are agreements between BLUP values with PCR-RFLP results to achieve a favorable selection response in reproductive performance of local quail in Kurdistan region, Iraqi.

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Let7a involves in neural stem cell differentiation relating with TLX level

Cited by 18 publications

References 34 publications

miR‐Let7A Controls the Cell Death and Tight Junction Density of Brain Endothelial Cells under High Glucose Condition

miR‐Let7A Controls the Cell Death and Tight Junction Density of Brain Endothelial Cells under High Glucose Condition

Cell Signaling in Neuronal Stem Cells

Three Candidate Genes and Its Association With Quantitative Variation of Egg Production Traites of Local Quail by Using PCR-RFLP

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