Let’s talk SUDEP

Elmalı, Ayşe Deniz; Bebek, Nerses; Baykan, Betül

doi:10.29399/npa.23663

Cited by 7 publications

(9 citation statements)

References 153 publications

(194 reference statements)

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“…SUDEP has been identified as one of the most frequent causes of death among patients with epilepsy. However, most of the cases are highly unrecognized and underreported as 90% of SUDEP cases are unwitnessed [ 12 ]. Therefore, the underlying pathophysiology remains incompletely understood.…”

Section: Discussionmentioning

confidence: 99%

Near-sudden unexpected death in a patient with epilepsy undergoing hemodialysis: a case report

Hatano¹,

Kanzaki

Marumoto

et al. 2021

CEN Case Rep

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Sudden unexpected death in epilepsy (SUDEP) has been defined as a sudden/unexpected, witnessed/unwitnessed, nontraumatic, and nondrowning death in epileptic patients with/without seizure evidence and documented status epilepticus. Identified as the leading cause of epilepsy-related deaths, SUDEP cases are highly unrecognized and underreported due to diagnostic difficulty. We report a case of a successfully revived hemodialysis patient who developed cardiopulmonary arrest after a witnessed convulsive seizure. Electroencephalogram revealed epileptic abnormalities. Therefore, this case could be seizure-induced cardiopulmonary arrest and near-SUDEP. Hence, the possibility of SUDEP should be considered even in hemodialysis patients having conventional coronary risk factors for sudden cardiac death.

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Section: Discussionmentioning

confidence: 99%

Near-sudden unexpected death in a patient with epilepsy undergoing hemodialysis: a case report

Hatano¹,

Kanzaki

Marumoto

et al. 2021

CEN Case Rep

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“…12 Seizure is such a multi-system event that it has impact on overall physiology of the body and if this phenomenon keeps on occurring and remains unchecked may cause threatening complications. 5 Antiepileptic drug's though play a vital role in control of epilepsy, yet have certain adverse effects which may need to be kept in mind as these medications may have to be administered for years. Newer anti-epileptics lack data on safety aspects therefore careful monitoring should be carried out regularly if patient is on any newer drug.…”

Section: Methodsmentioning

confidence: 99%

“…Respiratory problems, abnormal rhythm of heart, and altered cerebral blood flow have been some of the causes which were found on postmortem examinations and related to SUDEP among patients of epilepsy. 5,6 Still a lot of work has been under progress to find the exact cause or factors related to SUDEP in order to prevent this lethal condition.…”

Section: Introductionmentioning

confidence: 99%

Cardiac biomarkers in patients with epilepsy.

Hanif¹,

Siddiq²,

Zaib³

et al. 2021

TPMJ

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Objective: To determine the frequency of deranged cardiac biomarkers and associated socio-demographic factors among patients of epilepsy presenting at our hospital. Study Design: Cross-sectional study. Setting: Department of Medicine, Sheikh Khalifa Bin Zyed Al-Nyhan Hospital Rawalakot. Period: August 2019 to September 2020. Material & Methods: We evaluated 85 consecutive patients who presented at Department of Medicine, Sheikh Khalifa Bin Zyed Al-Nyhan hospital. Cardiac Biomarkers (Troponin I, CK-MB and pro-BNP) and EKG were requested in all patients. The questionnaire used for interview consisted of demographic details and disease related parameters (duration of epilepsy and number of antiepileptic drugs). Results: Out of 85 patients included in the study, 35 (41.2%) were male while 45 (58.8%) were female. Out of these 85 patients of epilepsy, 15 (17.6%) had one or more cardiac biomarker positive while 70 (82.4%) had no change in ECG or any positive cardiac biomarker. All ECG changes were non-specific. After applying the logistic regression, we found that long duration of illness and poly-pharmacy had significant association with the presence of positive cardiac biomarkers among the patients of epilepsy. Conclusion: Less than 1/5th of the patients with epilepsy had positive cardiac biomarkers or ECG changes in our study. Patients with longer duration of epilepsy or those whose epilepsy has been managed with more than one drug were found more at risk of having abnormal cardiac biomarkers in our target population.

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“…Klinik açıdan en önemli olanı, değiştirilebilir risk faktörlerinin tanınmasıdır (Tablo 2). [31] Önlemler SUDEP'in önlenmesinde göz önünde tutulması gereken en önemli faktörler efektif nöbet kontrolünün sağlanması, nöbet saptama cihazları ve monitörizasyonla efektif nöbet takibi yapılması, canlandırma girişimlerinin etkin ve erken uygulanması ile yaşam tarzı değişiklikleridir. Burada önlemler farmakolojik olmayan koruyucu yöntemleri, farmakolojik Tablo 1.…”

Section: Risk Faktörleriunclassified

“…Yeni cihazların potansiyel mortalite açısından faydalarının tespit edilebilmesi için uzun vadeli ve çok merkezli çalışmalara ihtiyaç vardır. [31] Kalp pilleri Kalp pilleri iktal asistoli olgularında kullanılmaktadır, ancak kalıcı kalp pillerinin SUDEP'te etkinliğini test eden sistemik bir çalışma yoktur. [66,67] Olası taşiaritmiyle ilişkili SUDEP olguları için, implante edilebilir bir kardiyoverter defibrilatör (ICD) daha uygun olabilir.…”

Section: Cerrahi Yöntemlerunclassified

Odadaki görünmez fil: SUDEP yani epilepsi hastalarında ani beklenmedik ölüm

Şirinocak¹

2019

Epilepsi

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Epilepsy is a disease characterized by recurring seizures. Sudden unexpected death in epilepsy patients (SUDEP), however rare, is very important. Precautions taken against this devastating and irreversible complication have substantial value. This review is a discussion of the definition of SUDEP, possible risk factors, and preventative measures. All neurologists and family medicine practitioners participating in the care of epilepsy patients should be well informed and very aware of this risk and preventative measures, as well as epilepsy patients and their caregivers. More research and programs to raise awareness of SUDEP, a deadly complication of epilepsy, are urgently needed.

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Let’s talk SUDEP

Cited by 7 publications

References 153 publications

Near-sudden unexpected death in a patient with epilepsy undergoing hemodialysis: a case report

Near-sudden unexpected death in a patient with epilepsy undergoing hemodialysis: a case report

Cardiac biomarkers in patients with epilepsy.

Odadaki görünmez fil: SUDEP yani epilepsi hastalarında ani beklenmedik ölüm

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