Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis

Li, Ling; Zhang, Xiujuan; Lin, Yanni; Ren, Xinxin; Xie, Tian; Lin, Jing; Wu, Shumeng; Ye, Qinong

doi:10.1038/s41420-023-01412-2

Cited by 8 publications

(2 citation statements)

References 48 publications

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“…Recently, another miRNA, let-7b-5p has garnered attention for its multifaceted role in regulating tumorigenesis and cancer progression. Notably, Let-7b-5p exerts inhibitory effects on BrCa cell growth and metastasis by repressing hexokinase 2-mediated aerobic glycolysis [58]. These findings collectively highlight the potential therapeutic application of miRNAs in the context of breast cancer therapy.…”

Section: Discussionmentioning

confidence: 77%

Comprehensive Analysis of the Expression, Prognosis, and Immune Infiltrates for Chromodomain-Helicase-DNA-Binding Proteins in Breast Tumor

Hasanlu,

Amiri-Dashatan,

Farahani

et al. 2024

Asian Pac J Cancer Prev

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Background: Several recent studies suggest that chromodomain-helicase -DNA-binding domains (CHDs) are linked with cancers. We explored the association between chromodomain-Helicase-DNA-binding domain proteins and breast cancer (BrCa) and introduced potential prognostic markers using various databases. Materials and Methods: We analyzed the expression of the CHD family and their prognostic value in BrCa by mining UALCAN, TIMER, and Kaplan-Meier plotter databases. The association of CHD expression and immune infiltrating abundance was studied via the TIMER database. In addition, microRNAs related to the CHD family were identified by using the MirTarBase online database. Results: The present study indicated that compared to normal tissues, BrCa tissues showed increased mRNA levels of CHD3/4/7 but decreased CHD2/5/9 expression. Interestingly, We also found a positive correlation between CHD gene expression and the infiltration of macrophage, neutrophil, and dendritic cells in BrCa, except CHD3/5. The Kaplan-Meier Plotter analysis suggested that high expression levels of CHD1/2/3/4/6/8/9 were significantly related to shorter relapse-free survival (RFS), while higher mRNA expression of CHD1, CHD2, CHD8, and CHD9 was significantly associated with longer overall survival of BrCa patients. The miRNAs of hsa-miR-615-3p and hsa-let-7b-5p were identified as being more correlated with the CHD family. Conclusion: The altered expression of some CHD members was significantly related to clinical cancer outcomes, and CHD1/2/8/9 could serve as potential prognostic biomarkers to improve the survival of BrCa patients. However, to evaluate the studied CHD members in detail are needed further investigations including experimental validation.

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Section: Discussionmentioning

confidence: 77%

Comprehensive Analysis of the Expression, Prognosis, and Immune Infiltrates for Chromodomain-Helicase-DNA-Binding Proteins in Breast Tumor

Hasanlu,

Amiri-Dashatan,

Farahani

et al. 2024

Asian Pac J Cancer Prev

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“…For example, let‐7b‐5p inhibits breast cancer cell growth and metastasis by suppressing HK2‐mediated aerobic glycolysis. 64 Also, miR‐16‐5p has been shown to inhibit breast cancer proliferation through ANLN, 65 and in another study, its increased expression was associated with inhibition of proliferation, invasion, and induction of apoptosis in breast cancer. 66 In addition, miR‐34a‐5p and miR‐7‐5p can induce apoptosis and suppress proliferation and migration of breast cancer cells.…”

Section: Discussionmentioning

confidence: 98%

In silico identification and in vitro evaluation of MRPS30‐DT lncRNA and MRPS30 gene expression in breast cancer

Shirani,

Mahdi‐Esferizi,

Eshraghi Samani

et al. 2024

Cancer Reports

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BackgroundIt has been reported that long non‐coding RNAs (lncRNAs) can play important roles in a variety of biological processes and cancer regulatory networks, including breast cancer.AimsThis study aimed to identify a novel upregulated lncRNA in breast cancer and its associated gene using bioinformatics analysis, and then evaluate their potential roles in breast cancer.Methods and ResultsExtensive in silico studies were performed using various bioinformatics databases and tools to identify a potential upregulated breast cancer‐associated lncRNA and its co‐expressed gene, and to predict their potential roles, functions, and interactions. The expression level of MRPS30‐DT lncRNA and MRPS30 was assessed in both BC tissues and cell lines using qRT‐PCR technology. MRPS30‐DT lncRNA and MRPS30 were selected as target genes using bioinformatics analysis. We found that MRPS30‐DT and MRPS30 were significantly overexpressed in BC tissues compared with normal tissues. Also, MRPS30 showed upregulation in all three BC cell lines compared with HDF. On the other hand, MRPS30‐DT significantly increased in MDA‐MB‐231 compared with HDF. While the expression of MRPS30‐DT was significantly dropped in the resistance cell line MCF/MX compared to HDF and MCF7. Moreover, bioinformatics analysis suggested that MRPS30‐DT and MRPS30 may play a potential role in BC through their involvement in some cancer signaling pathways and processes, as well as through their interaction with TFs, genes, miRNAs, and proteins related to carcinogenesis.ConclusionsOverall, our findings showed the dysregulation of MRPS30‐DT lncRNA and MRPS30 may provide clues for exploring new therapeutic targets or molecular biomarkers in BC.

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Predictive action of oncomiR in suppressing TP53 signaling pathway in hypoxia‐conditioned colon cancer cell line HCT‐116

Susanti,

Dafip,

Mustikaningtyas

et al. 2024

Cell Biology International

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Hypoxia‐induced heterogeneity in colorectal cancer (CRC) significantly impacts patient survival by promoting chemoresistance. These conditions alter the regulation of miRNAs, key regulators of crucial processes like proliferation, apoptosis, and invasion, leading to tumor progression. Despite their promising potential as diagnostic and therapeutic targets, the underlying mechanisms by which miRNAs influence hypoxia‐mediated tumorigenesis remain largely unexplored. This study aims to elucidate the action of miRNAs in HCT‐116 colorectal cancer stem cells (CSCs) under hypoxia, providing valuable insights into their role in tumor adaptation and progression. MiRNA expression was determined using Nanostring nCounter, and bioinformatic analysis was performed to explain the molecular pathway. A total of 50 miRNAs were obtained with an average count of ≥ 20 reads for comparative expression analysis. The results showed that hypoxia‐affected 36 oncomiRs were increased in HCT‐116, and 14 suppressor‐miRs were increased in MSCs. The increase in miRNA expression occurred consistently from normoxia to hypoxia and significantly differed between mesenchymal stem cells (MSCs) and HCT‐116. Furthermore, miR‐16‐5p and miR‐29a‐3p were dominant in regulating the p53 signaling pathway, which is thought to be related to the escape mechanism against hypoxia and maintaining cell proliferation. More research with a genome‐transcriptome axis approach is needed to fully understand miRNAs’ role in adapting CRC cells and MSCs to hypoxia. Further research could focus on developing specific biomarkers for diagnosis. In addition, anti‐miR can be developed as a therapy to prevent cancer proliferation or inhibit the adaptation of cancer cells to hypoxia.

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Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis

Cited by 8 publications

References 48 publications

Comprehensive Analysis of the Expression, Prognosis, and Immune Infiltrates for Chromodomain-Helicase-DNA-Binding Proteins in Breast Tumor

Comprehensive Analysis of the Expression, Prognosis, and Immune Infiltrates for Chromodomain-Helicase-DNA-Binding Proteins in Breast Tumor

In silico identification and in vitro evaluation of MRPS30‐DT lncRNA and MRPS30 gene expression in breast cancer

Predictive action of oncomiR in suppressing TP53 signaling pathway in hypoxia‐conditioned colon cancer cell line HCT‐116

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