Lessons learned: new insights on the role of cytokines in COVID-19

Buszko, Maja; Nita‐Lazar, Aleksandra; Park, Jung Hyun; Schwartzberg, Pamela L.; Verthelyi, Daniela; Young, Howard A.; Rosenberg, Amy S.

doi:10.1038/s41590-021-00901-9

Cited by 86 publications

(98 citation statements)

References 36 publications

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“…Loss of plasmacytoid dendritic cells and basophils and T cell depletion, mainly CD8+ and γδT cells, are important features of the COVID-19 immune response. The expressions of cytokines, mainly IL-6-, IL-10-, and IFNγ-induced protein 10 (IP-10, previously CXCL10), are increased, and their expression is closely correlated with disease progression [ 70 ]. IP-10 is of particular interest because its concentrations frequently remain elevated throughout the COVID-19 response similar to in ME/CFS patients [ 61 ].…”

Section: What Causes Post-infectious Fatigue Syndromes and Me/cfs In Covid19 Patients?mentioning

confidence: 99%

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection

Moghimi

Napoli

Biller

et al. 2021

Curr Neurol Neurosci Rep

139

102

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Purpose of Review Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health challenge. This review aims to summarize the incidence, risk factors, possible pathophysiology, and proposed management of neurological manifestations of post-acute sequelae of SARS-CoV-2 infection (PASC) or neuro-PASC based on the published literature. Recent Findings The National Institutes of Health has noted that PASC is a multi-organ disorder ranging from mild symptoms to an incapacitating state that can last for weeks or longer following recovery from initial infection with SARS-CoV-2. Various pathophysiological mechanisms have been proposed as the culprit for the development of PASC. These include, but are not limited to, direct or indirect invasion of the virus into the brain, immune dysregulation, hormonal disturbances, elevated cytokine levels due to immune reaction leading to chronic inflammation, direct tissue damage to other organs, and persistent low-grade infection. A multidisciplinary approach for the treatment of neuro-PASC will be required to diagnose and address these symptoms. Tailored rehabilitation and novel cognitive therapy protocols are as important as pharmacological treatments to treat neuro-PASC effectively. Summary With recognizing the growing numbers of COVID-19 patients suffering from neuro-PASC, there is an urgent need to identify affected individuals early to provide the most appropriate and efficient treatments. Awareness among the general population and health care professionals about PASC is rising, and more efforts are needed to understand and treat this new emerging challenge. In this review, we summarize the relevant scientific literature about neuro-PASC.

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Section: What Causes Post-infectious Fatigue Syndromes and Me/cfs In Covid19 Patients?mentioning

confidence: 99%

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection

Moghimi

Napoli

Biller

et al. 2021

Curr Neurol Neurosci Rep

139

102

View full text Add to dashboard Cite

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“…Besides, HLA mismatching and the likelihood of graft-versus-host disease (GvHD) is a legitimate concern for the enrolled patients in the mentioned trials [55] , [65] . Moreover, considering the lack of data on the causes of maladaptive responses to SARS-CoV2, the VST cells derived from convalescent donors may have an over/auto-reactive behavior [66] , [67] , and thus, the adoptive transfer of such aberrant lymphocytes to a COVID-19 patient may put them at a serious risk and jeopardize the primary intent (i.e., treating a COVID-19 patient). Hence and as a further step, the TCRs of the avid SARS-CoV2-specific T cells derived from the convalescent donors can be sequenced, so that the relevant encoding genes can be used for engineering the autologous naïve t cells to forced express SARS-CoV2-specific TCRs.…”

Section: Virus-specific Effector Lymphoid Cellsmentioning

confidence: 99%

An outlook on antigen-specific adoptive immunotherapy for viral infections with a focus on COVID-19

Monzavi

Naderi

Ahmadbeigi

et al. 2021

Cellular Immunology

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“…In addition we also observe trends in the cytokine features that lead to reactions in the immune system that occur as a result of the trauma (including Il6, IL8, Neutrophils [8]). Understanding Cytokine reactions may also be useful in studying severe acute respiratory syndrome coronavirus [31,32]. There are several heterogeneous experiments in this framework that are conducted resulting in time series datasets with survivability or clotting outcomes.…”

Section: Motivating Scenariomentioning

confidence: 99%

Temporal Progression: A case study in Porcine Survivability through Hemostatic Nanoparticles

Kulkarni

Maisha

et al. 2021

Preprint

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This paper focuses on the analysis of time series representation of blood loss and cytokines in animals experiencing trauma to understand the temporal progression of factors affecting survivability of the animal. Trauma related grave injuries cause exsanguination and lead to death. 50% of deaths especially in the armed forces are due to trauma injuries. Restricting blood loss usually requires the presence of first responders, which is not feasible in certain cases. Hemostatic nanoparticles have been developed to tackle these kinds of situations to help achieve efficient blood coagulation. Hemostatic nanoparticles were administered into trauma induced porcine animals (pigs) to observe impact on the cytokine and blood loss experienced by them. In this paper we present temporal models to study the impact of the hemostatic nanoparticles and provide snapshots about the trend in cytokines and blood loss in the porcine data to study their progression over time. We utilized Piecewise Aggregate Approximation, Similarity based Merging and clustering to evaluate the impact of the different hemostatic nanoparticles administered. In some cases the fluctuations in the cytokines may be too small. So in addition we highlight situations where temporal modelling that produces a smoothed time series may not be useful as it may remove out the noise and miss the overall fluctuations resulting from the nanoparticles. Our results indicate certain nanoparticles stand out and lead to novel hypothesis formation.

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Lessons learned: new insights on the role of cytokines in COVID-19

Cited by 86 publications

References 36 publications

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection

An outlook on antigen-specific adoptive immunotherapy for viral infections with a focus on COVID-19

Temporal Progression: A case study in Porcine Survivability through Hemostatic Nanoparticles

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