Lessons learned from water/sediment-testing of pharmaceuticals

Radke, Michael; Maier, Michael P.

doi:10.1016/j.watres.2014.02.012

Cited by 67 publications

(75 citation statements)

References 29 publications

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“…95,96) In the water exposure of this water milfoil to 14 C-phenol derivatives, the correlation of log k up , estimated similarly to the duckweed study above, with log K ow was slightly higher (r=0.66) but was not improved by consideration of log D instead. 96) Re-analysis of the log BCF values 86) for twelve non-polar pesticides in nine species of aquatic macrophytes showed the low correlation with log K ow (r 2 =0.43), and a significant variation of BCF up to two orders of magnitude was observed for each pesticide among these species.…”

Section: Contribution Of Phototrophic Microorganismsmentioning

confidence: 59%

“…12) The different dissipation rates between the laboratory and field studies have been frequently reported for pesticides 13) and pharmaceuticals, 14) although their metabolic profiles are similar. In a sunlit environment, unique products may be formed by photolysis via rearrangement and radical reactions, 13,15) and the presence of aquatic macrophytes and phototrophic microorganisms including algae not only gives an additional phase for adsorption but also causes further metabolic degradation of the dissolved pesticide.…”

Section: Introductionmentioning

confidence: 89%

“…107) In the illuminated fluvarium channel, more hydrolytically unstable trans-permethrin was less distributed in the biofilm than the cis-isomer, 76) being accounted for by the above mechanism. Under the non-UV light exposure at >400 nm, the DT 50 values of 14 C-isopyrazam markedly decreased and the fungicide amounted to only 30% of 14 C in the sediment, indicating its sorption and metabolism by algae at the sediment surface. 34) Comparative studies using the fluorescent light at >400 nm have recently been conducted for several 14 C-pesticides.…”

Section: Effects Of Algae and Phototrophic Microorganismsmentioning

confidence: 98%

“…Under the non-UV light exposure at >400 nm, the DT 50 values of 14 C-isopyrazam markedly decreased and the fungicide amounted to only 30% of 14 C in the sediment, indicating its sorption and metabolism by algae at the sediment surface. 34) Comparative studies using the fluorescent light at >400 nm have recently been conducted for several 14 C-pesticides. 67) Photosynthesis-driven pH elevation caused the very rapid hydrolysis of pinoxaden with a slight effect of algae on the dissipation of the hydrophilic diketone metabolite.…”

Section: Effects Of Algae and Phototrophic Microorganismsmentioning

confidence: 98%

“…92) Although no uptake of mecoprop was observed likely due to its complete ionization in the tested water (pK a =3.86 93) ), the log CF values of the other undissociated pesticides correlated well with log K ow 13) (r 2 =0.99, n=4). The relative uptake rate constants (k up ) of six 14 C-labeled phenol derivatives by the axenic L. gibba were estimated by the compartmental model kinetic analysis considering the phase-II conjugations and bound formation, and the low correlation (r=0.55) of log k up with log K ow was slightly improved (r=0.76) when the fraction of an undissociated species was taken into account for each phenol (pK a =7.15-9.98).…”

Section: Contribution Of Phototrophic Microorganismsmentioning

confidence: 99%

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Pesticide behavior in modified water-sediment systems

Katagi

2016

J. Pestic. Sci.

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The standardized laboratory water-sediment study in darkness is utilized as primary information on pesticide behavior to assess its ecotoxicological impacts in the edge-of-field water bodies. The half-lives of pesticide in water and sediment are key parameters to predict its environmental concentration, and its metabolic profiles help to avoid overlooking unexpected toxicological impacts from metabolites. However, no consideration of environmental factors such as sunlight and aquatic macrophytes is included, and this may lead to a conservative assessment. We review the experimental factors in the existing standardized design and then the effects of illumination and aquatic macrophytes introduced to the water-sediment system. The effects of temperature and the water-sediment ratio should be investigated in more detail and the pesticide behavior is possibly modified by illumination via photodegradation and/or metabolism in phototrophic microorganisms. Aquatic macrophytes play a major role as an additional sorption site and in further pesticide metabolism.

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Section: Contribution Of Phototrophic Microorganismsmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 89%

Section: Effects Of Algae and Phototrophic Microorganismsmentioning

confidence: 98%

Section: Effects Of Algae and Phototrophic Microorganismsmentioning

confidence: 98%

Section: Contribution Of Phototrophic Microorganismsmentioning

confidence: 99%

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Pesticide behavior in modified water-sediment systems

Katagi

2016

J. Pestic. Sci.

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Inverse modeling of laboratory experiment to assess parameter transferability of pesticide environmental fate into outdoor experiments under paddy test systems

Kondo¹,

Wakasone²,

Iijima³

et al. 2020

Pest Management Science

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BackgroundExtraction of environmental fate parameters for pesticides by inverse modeling in laboratory experiments has evolved to become a common practice in higher tier exposure modeling. This study focuses on flooded paddy soil conditions using a simple container test system. Four active ingredients of paddy herbicide were tested. The results were parameterized and transferred to analyze the effect of formulation types on the outdoor experimental data via inverse analyses of two structurally‐compatible mathematical models, namely: pesticide concentration in paddy field for laboratory (PCPF‐LR) and PCPF for outdoors (PCPF‐1Rv1.1).ResultsAfter in‐laboratory calibration, the PCPF‐LR model revealed statistically acceptable or ideal simulations of pesticide concentrations in both the aqueous and soil phases (e.g. Nash–Sutcliffe efficiency > 0.7), in addition to determining the apparent sorption from the laboratory data. The extracted persistence indicators (degradation half‐life, DegT50) in the aqueous phase were 1.4–38.7 times higher than those of the dissipation (DT50) due to the exclusion of partitioning and phase transfer processes (diffusion and sorption). In the outdoor experiment, 72% of the outdoor‐calibrated simulations of the PCPF‐1Rv1.1 model, showed statistically acceptable representations of the concentrations in paddy water. Furthermore, the DegT50 as ‘bulk’ degradation in paddy water was statistically insignificant between the formulation types; however, the DT50 demonstrated statistically different results.ConclusionThe laboratory/outdoor data interconnections using proposed modeling approach facilitate the data‐specific model calibration and analysis. These can be useful in the exposure modeling of paddy pesticide by manipulating the parameter uncertainties associated with the experimental constraints. © 2020 Society of Chemical Industry

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Determination of carbamazepine and 12 degradation products in various compartments of an outdoor aquatic mesocosm by reliable analytical methods based on liquid chromatography-tandem mass spectrometry

Danièle

Fieu

Joachim

et al. 2017

Environ Sci Pollut Res

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The aims of this work are to develop suitable analytical methods to determine the widely used anticonvulsant carbamazepine and 12 of its degradation/transformation products in water, sediment, fish (Gasterosteus aculeatus) and mollusc (Dreissena polymorpha). Protocols based on solid phase extraction for water, pressurized-liquid extraction for sediments and QuEChERS (quick easy cheap efficient rugged and safe) extraction for both organisms followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) are developed, validated and finally applied to samples collected during a 6-month experiment in outdoor mesocosms. Very low detection limits are reached, allowing environmentally realistic doses (namely, 0.05, 0.5 and 5 μg/L nominal concentrations) to be employed. The results indicate several metabolites and/or transformation products in each compartment investigated, with concentrations sometimes being greater than that of the parent carbamazepine. Biotic degradation of carbamazepine is demonstrated in water, leading to 10,11-dihydrocarbamazepine and 10,11-epoxycarbamazepine. In sediment, the degradation results in the formation of acridine, and 2- and 3-hydroxycarbamazepine. Finally, in both organisms, a moderate bioaccumulation is observed together with a metabolization leading to 10,11-epoxycarbamazepine in fish and 2-hydroxycarbamazepine in mollusc. Acridone is also present in fish. This study provides new and interesting data, helping to elucidate how chronic exposure to carbamazepine at relevant concentrations may affect impact freshwater ecosystems.

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Lessons learned from water/sediment-testing of pharmaceuticals

Cited by 67 publications

References 29 publications

Pesticide behavior in modified water-sediment systems

Pesticide behavior in modified water-sediment systems

Inverse modeling of laboratory experiment to assess parameter transferability of pesticide environmental fate into outdoor experiments under paddy test systems

Determination of carbamazepine and 12 degradation products in various compartments of an outdoor aquatic mesocosm by reliable analytical methods based on liquid chromatography-tandem mass spectrometry

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