Lessons from SARS‑CoV‑2 and its variants (Review)

Qin, Ziwen; Sun, Yan; Zhang, Jian; Zhou, Ling; Chen, Yujuan; Huang, Chuanjun

doi:10.3892/mmr.2022.12779

Cited by 5 publications

(1 citation statement)

References 229 publications

(172 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coronavirus disease 2019 (COVID-19) was identified in January 2020 and since this time has been the cause of global human-to-human transmission ( 1 , 2 ). Five variants of concern (VOC) have been identified so far, namely Alpha, Beta, Gamma, Delta, and Omicron as designated by the World Health Organization (WHO) ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Factors associated with prolonged viral shedding in older patients infected with Omicron BA.2.2

Zhong

Yang

Jiang

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundThis study explores the risk factors associated with viral shedding time in elderly Chinese patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron.MethodsParticipants infected with SARS-CoV-2 omicron were enrolled in a retrospective study, and divided into two groups according to shedding time (≥10 days, “late clearance group” and <10 days, “early clearance group”).ResultsA total of 180 patients were enrolled in the study (88 early, 92 late), with a median viral shedding time of 10 days and a mean age of 77.02 years. Prolonged SARS-CoV-2 omicron shedding was associated with old age (p = 0.007), lack of vaccination (p = 0.001), delayed admission to hospital after onset of diagnosis (p = 0.001), D-dimer (p = 0.003), and methylprednisolone treatment (p = 0.048). In multivariate analysis, vaccination (OR, 0.319, 95% CI, 0.130–0.786, p = 0.013), Paxlovid (OR, 0.259, 95% CI, 0.104–0.643, p = 0.004), and time from onset of diagnosis to admission (OR, 1.802, 95% CI, 1.391–2.355, p = 0.000) were significantly associated with viral clearance.ConclusionsTime from onset of diagnosis to hospitalization, lack of treatment with Paxlovid, and lack of vaccination were independent risk factors in elderly Chinese patients infected with SARS-CoV-2 omicron for prolonged viral shedding.

show abstract