Lessons from other fields of medicine, Part 2: Cystic fibrosis

Phenotype parallels protein seeding capacity in neurodegenerative diseases

“…Understanding the relationship between the seeding differences and biological activity of α-Syn and tau will be critical for future subclassification of neurodegenerative diseases, which, as proposed in other diseases, such as cancer [14] or cystic fibrosis [15], should go beyond the conventional clinical and neuropathological phenotyping and consider the structural and biochemical heterogeneity of α-Syn and tau present in these patients.…”

“…Using a multi‐pronged strategy, several groups have discovered unexpected differences in the seeding capacity of neurodegenerative disease associated proteins across a cohort of neuropathologically comparable brains. Understanding the relationship between the seeding differences and biological activity of α‐Syn and tau will be critical for future subclassification of neurodegenerative diseases, which, as proposed in other diseases, such as cancer [ 14 ] or cystic fibrosis [ 15 ], should go beyond the conventional clinical and neuropathological phenotyping and consider the structural and biochemical heterogeneity of α‐Syn and tau present in these patients.…”