Lessons from mouse models in the impact of risk factors on the genesis of childhood B-cell leukemia
Ana Casado-García,
Marta Isidro-Hernández,
Silvia Alemán-Arteaga
et al.
Abstract:B-cell acute lymphoblastic leukemia (B-ALL) stands as the primary contributor to childhood cancer-related mortality on a global scale. The development of the most conventional forms of this disease has been proposed to be conducted by two different steps influenced by different types of risk factors. The first step is led by a genetic insult that is presumably acquired before birth that transforms a healthy cell into a preleukemic one, which is maintained untransformed until the second step takes place. This n… Show more
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