Lessons for Neurotoxicology from Selected Model Compounds: SGOMSEC Joint Report

Rice, Deborah C.; Duffard, Ana María Evangelista de; Duffard, Ricardo; Iregren, Anders; Satoh, Hiroshi; Watanabe, Chiho

doi:10.2307/3432642

Cited by 5 publications

(5 citation statements)

References 34 publications

(49 reference statements)

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“…Most of the studies documented a robust relationship between in utero and postnatal exposure to lead and the long-term neuropsychological morbidities, as well as resulting juvenile delinquency and criminality during early adulthood. 13,[34][35][36][37][38][39][40][41][42] As a consequence of these and other studies, the Centers for Disease Control and Prevention lowered the lead action level for children to 10 µg/dl, and more recently set a 'reference value' of 5 µg/dl (see http://www.cdc.gov/nceh/lead/ACCLPP/blood_lead_levels. htm).…”

Section: Pptox Conferences Highlight Progress In Dohad and Environmenmentioning

confidence: 99%

Evolution of DOHaD: the impact of environmental health sciences

Haugen

Schug

Collman

et al. 2014

J Dev Orig Health Dis

177

112

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Environmental exposures have a significant influence on the chronic health conditions plaguing children and adults. Although the Developmental Origins of Health and Disease (DOHaD) paradigm historically has focused on nutrition, an expanding body of research specifically communicates the effects of chemical exposures on early-life development and the propagation of non-communicable disease across the lifespan. This paper provides an overview of 20 years of research efforts aimed at identifying critical windows of susceptibility to environmental exposures and the signaling changes and epigenetic influences associated with disease progression. DOHaD grants funded by the National Institute of Environmental Health Sciences (NIEHS) in 1991, 2001 and 2011 are identified by grant-analysis software, and each portfolio is analyzed for exposures, disease endpoints, windows of exposure, study design and impact on the field based on publication data. Results show that the 1991 and 2001 portfolios comprised metals, PCBs and air pollutants; however, by 2011, the portfolio has evolved to include or expand the variety of endocrine disruptors, pesticides/persistent organic pollutants and metals. An assortment of brain-health endpoints is most targeted across the portfolios, whereas reproduction and cancer increase steadily over the same time period, and new endpoints like obesity are introduced by 2011. With mounting evidence connecting early-life exposures to later-life disease, we conclude that it is critical to expand the original DOHaD concept to include environmental chemical exposures, and to continue a research agenda that emphasizes defining sensitive windows of exposure and the mechanisms that cause disease.

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Section: Pptox Conferences Highlight Progress In Dohad and Environmenmentioning

confidence: 99%

Evolution of DOHaD: the impact of environmental health sciences

Haugen

Schug

Collman

et al. 2014

J Dev Orig Health Dis

177

112

View full text Add to dashboard Cite

show abstract

“…Chronic or low-dose exposure was considered benign until the landmark observation of an association between higher lead levels in teeth and difficulty following classroom instruction, unruly behavior, greater distractibility, and reduced auditory and verbal processing, attention, and IQ scores, particularly on verbal components (Needleman et al, 1979). These results demonstrated that intellectual impairments and problematic behaviors could result from lead levels that were “regarded as normal” at the time (Rice et al, 1996, p. 205).…”

Section: Environmental Toxicantsmentioning

confidence: 95%

“…The investigator’s relative expertise with behavioral testing and interpretation, the choice of animal model, and the choice of functional system (e.g., specific sensory, motor, cognitive, or social) can all affect and potentially undermine the utility of test results as applied to human development (Cory-Slechta et al, 2001). In general, findings from nonhuman studies often significantly underestimate the effects on human populations because subtle cognitive impairments are often difficult to detect in nonhuman populations (Cory-Slechta et al, 2001; Rice et al, 1996).…”

Section: Establishing Cause and Effect: A Research Nightmarementioning

confidence: 99%

“…As Weiss (2000) noted, “if environmental contamination diminishes IQ in the U.S. population by an average of 1%, the annual cost would come to $50 billion and the lifetime costs to trillions” (p. 380). This sum is most likely an underestimate because “small decrements in population IQ will not only decrease the number of people with IQs above 130, but will concurrently increase the number of those with IQs below 70, thereby increasing demand for remedial education and other services” (p. 380; see also Schwartz, 1994; Rice et al, 1996).…”

Section: The Costs Of Developmental Disabilitiesmentioning

confidence: 99%

See 1 more Smart Citation

Environmental Toxicants and Developmental Disabilities: A Challenge for Psychologists.

Koger¹,

Schettler²,

Weiss³

2005

American Psychologist

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Developmental, learning, and behavioral disabilities are a significant public health problem. Environmental chemicals can interfere with brain development during critical periods, thereby impacting sensory, motor, and cognitive function. Because regulation in the United States is based on limited testing protocols and essentially requires proof of harm rather than proof of lack of harm, some undefined fraction of these disabilities may reflect adverse impacts of this "vast toxicological experiment" (H. L. Needleman, as quoted in B. Weiss & P. J. Landrigan, 2000, p. 373). Yet the hazards of environmental pollutants are inherently preventable. Psychologists can help prevent developmental disabilities by mobilizing and affecting public policy, educating and informing consumers, contributing to interdisciplinary research efforts, and taking action within their own homes and communities to reduce the toxic threat to children.

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“…In cases where there is both dose-response data for animals and humans, for the same (or similar) endpoints, it has been possible to assess the ability of toxicology studies to predict human health impacts. In the case of a number of neurotoxic compounds, for example, it was found that more sensitive measures of neurologic damage ("functional" batteries) and different means of assessing dose (body burdens rather than average daily doses) could increase the ability to predict low level effects in humans (16).…”

Section: Role Of Epidemiology In Regulationmentioning

confidence: 99%