Lessons and Perspectives on Heart Failure Management From Considerations Based on the CHART-2 Study

Sato, Naoki

doi:10.1253/circj.cj-15-0712

Cited by 1 publication

(1 citation statement)

References 12 publications

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“…The results were encouraging and showed an increase in LVEF [5,26]. They lead to the two ongoing phase III Congestive Heart failure Cardiopoietic Regenerative Therapy trials (CHART-1 and CHART-2, NCT01768702) [6,27,28]. Nevertheless, the differentiation capacity of MSCs should be investigated in more detail.…”

Section: Mscsmentioning

confidence: 99%

Cardiac Regenerative Medicine: The Potential of a New Generation of Stem Cells

Cambria

Steiger

Günter

et al. 2016

Transfus Med Hemother

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Cardiac stem cell therapy holds great potential to prompt myocardial regeneration in patients with ischemic heart disease. The selection of the most suitable cell type is pivotal for its successful application. Various cell types, including crude bone marrow mononuclear cells, skeletal myoblast, and hematopoietic and endothelial progenitors, have already advanced into the clinical arena based on promising results from different experimental and preclinical studies. However, most of these so-called first-generation cell types have failed to fully emulate the promising preclinical data in clinical trials, resulting in heterogeneous outcomes and a critical lack of translation. Therefore, different next-generation cell types are currently under investigation for the treatment of the diseased myocardium. This review article provides an overview of current stem cell therapy concepts, including the application of cardiac stem (CSCs) and progenitor cells (CPCs) and lineage commitment via guided cardiopoiesis from multipotent cells such as mesenchymal stem cells (MSCs) or pluripotent cells such as embryonic and induced pluripotent stem cells. Furthermore, it introduces new strategies combining complementary cell types, such as MSCs and CSCs/CPCs, which can yield synergistic effects to boost cardiac regeneration.

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