Lesson of the week: A family cluster of Chlamydia trachomatis infection

Thompson, C. J.

doi:10.1136/bmj.322.7300.1473

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…While there are no published reports that clearly describe ocular to UGT transmission, or autoinoculation, it is well known that transmission from the UGT to the ocular site occurs in the setting of paratrachoma, and there is also evidence for transmission within families that could involve multiple modes. 2 8 9 …”

Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatisgenotypes in a cross-sectional study of urogenital samples from remote Northern and Central Australia

et al. 2016

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ObjectivesThe objective was to determine the frequency of trachoma genotypes of Chlamydia trachomatis-positive urogenital tract (UGT) specimens from remote areas of the Australian Northern Territory (NT).SettingThe setting was analysis of remnants of C. trachomatis positive primarily UGT specimens obtained in the course of clinical practice. The specimens were obtained from two pathology service providers.ParticipantsFrom 3356 C. trachomatis specimens collected during May 2012–April 2013, 439 were selected for genotyping, with a focus on specimens from postpubescent patients, in remote Aboriginal communities where ocular trachoma is potentially present.Primary and secondary outcome measuresThe primary outcome measure was the proportion of successfully genotyped UGT specimens that were trachoma genotypes. The secondary outcome measures were the distribution of genotypes, and the frequencies of different classes of specimens able to be genotyped.ResultsZero of 217 successfully genotyped UGT specimens yielded trachoma genotypes (95% CI for frequency=0–0.017). For UGT specimens, the genotypes were E (41%), F (22%), D (21%) and K (7%), with J, H and G and mixed genotypes each at 1–4%. Four of the five genotyped eye swabs yielded trachoma genotype Ba, and the other genotype J. Two hundred twenty-two specimens (50.6%) were successfully genotyped. Urine specimens were less likely to be typable than vaginal swabs (p<0.0001).ConclusionsUnlike in some other studies, in the remote NT, trachoma genotypes of C. trachomatis were not found circulating in UGT specimens from 2012 to 2013. Therefore, C. trachomatis genotypes in UGT specimens from young children can be informative as to whether the organism has been acquired through sexual contact. We suggest inclusion of C. trachomatis genotyping in guidelines examining the source of sexually transmitted infections in young children in areas where trachoma genotypes may continue to circulate, and continued surveillance of UGT C. trachomatis genotypes.

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Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatisgenotypes in a cross-sectional study of urogenital samples from remote Northern and Central Australia

et al. 2016

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“…2 Many of these infants develop conjunctivitis, pneumonia, or both in the first few months of life. 3 Chlamydia trachomatis pneumonia, although often mild, may cause severe symptoms that require hospitalization. 2 Until recently, the Committee on Infectious Diseases (the Red Book Committee) of the American Academy of Pediatrics recommended a prophylactic 14-day course of oral erythromycin for newborns exposed to C trachomatis at delivery.…”

Section: G Enital Infection Withmentioning

confidence: 99%

Oral Erythromycin Prophylaxis vs Watchful Waiting in Caring for Newborns Exposed to Chlamydia trachomatis

Rosenman

Mahon

Downs

et al. 2003

Arch Pediatr Adolesc Med

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“…The ocular‐genital appearance of chlamydial infections has been probed in a high percentage of the cases. According to some reports, genital and extragenital simultaneous presentation are very common (Dawson & Schachter, 1999) and include family cluster infections (Thompson et al. , 2001).…”

Section: Infertility Incidence and Prevalence Of Genitourinary Infecmentioning

confidence: 99%

Update on the impact of Chlamydia trachomatis infection on male fertility

Gonzales¹,

Muñoz²,

Sánchez³

et al. 2004

Andrologia

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With approximately 90 million cases annually, infection with Chlamydia trachomatis is the most prevalent sexually transmitted bacterial disease in the world. Considering that these infections are often asymptomatic and cause major complications like acute pelvic inflammatory disease, ectopic pregnancy, infertility or infant pneumonia, the estimated costs for diagnosis and treatment in the USA amounts to 2.2 million US dollars for each 500 cases. Therefore, there is a high need for correct, quick and cost-effective diagnosis and treatment of this urogenital tract infection. New innovative therapies provide good results with regard to efficacy and patients' compliance. The success rates of treatments are at least 95%. However, the occurrence of antibiotic resistance should not be ignored and new treatment schemes must be developed. The state-of-the-art of diagnosis and treatment of chlamydial infections as well as the pathophysiology is discussed in this review. In conclusion, infections with C. trachomatis is an important public health problem, especially in third world and developing countries, and more socio-economic studies linking secondary prevention of chlamydial infections, infertility and adverse pregnancy outcome are needed to understand more of its aetiology. In addition, diagnosis and treatment should be improved. Data in men revealed that past infections but not present infections are more related to male infertility. There is still controversial results. In future studies, function of the seminal vesicles and evaluation of the antioxidant capacity should be taken into account when role of C. trachomatis infection on male fertility is assessed.

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Lesson of the week: A family cluster of Chlamydia trachomatis infection

Cited by 12 publications

References 10 publications

Chlamydia trachomatisgenotypes in a cross-sectional study of urogenital samples from remote Northern and Central Australia

Chlamydia trachomatisgenotypes in a cross-sectional study of urogenital samples from remote Northern and Central Australia

Oral Erythromycin Prophylaxis vs Watchful Waiting in Caring for Newborns Exposed to Chlamydia trachomatis

Update on the impact of Chlamydia trachomatis infection on male fertility

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