Lesson from the COVID-19 pandemic lockdown: A major change of hospital-diagnosed bacteremia epidemiology

Cauhapé, Vincent; Lamy, Brigitte; Lotte, Romain; Touitou, Isabelle; Boyer, Laurent; Contenti, Julie; Parisot, F.; Ruimy, Raymond; Carlès, Michel; Courjon, Johan

doi:10.1016/j.idnow.2023.104709

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…Notably, the increased resistance of E. coli and K. pneumoniae to antibiotics during Phase II played a significant role in the complications observed, which aligns with findings from France, where a study reported an uptick in documented monomicrobial bacteremia in 2020 compared to 2019 (Cauhape et al, 2023). Another French study noted not only an increase in bloodstream infections but also a heightened incidence of infections caused by organisms resistant to third-generation cephalosporins (3GC) during the lockdown compared to the corresponding period in 2019 (Amarsy et al, 2022).…”

Section: Discussionsupporting

confidence: 85%

“…These measures have impacted hospital protocols, leading to tightened infection-control practices and changes in medical care delivery such as deprogramming of elective surgeries and restricting of physical visits. For instance, social distancing has been linked to reduced bacteremia, while endogenous infection cases such as hospital-diagnosed bacteremia associated with the NPIs have risen ( Brueggemann et al., 2021 ; Cauhape et al., 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Impacts of COVID-19 pandemic on culture-proven sepsis in neonates

Yang,

Ren,

Gong

et al. 2024

Front. Cell. Infect. Microbiol.

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ObjectiveTo assess the effects of COVID-19 pandemic on the epidemiology of neonatal sepsis and the antibiotic resistance profiles of pathogens involved.MethodsThis retrospective cohort study analyzed infants diagnosed with culture-proven sepsis at the neonatal department of a tertiary children’s hospital in East China from January 2016 to December 2022. We compared the clinical and microbiological characteristics of neonatal sepsis cases between the pre-pandemic Phase I (2016–2019) and during the COVID-19 pandemic Phase II (2020–2022).ResultsA total of 507 infants with 525 sepsis episodes were included, with 343 episodes in Phase I and 182 in Phase II. The incidence of early-onset sepsis (EOS) was significantly lower during Phase II (p < 0.05). Infants in Phase II had lower gestational ages and birth weights compared to Phase I. Clinical signs such as mottled skin, severe anemia, thrombocytopenia were more prevalent in Phase II, alongside a higher incidence of complications. Notably, necrotizing enterocolitis (NEC) (p < 0.05) and meningitis (p < 0.1) occurred more frequently during Phase II. Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) were the predominant pathogens isolated from infants of death and cases with complications. A significant decrease in the proportion of K. pneumoniae was observed in Phase II, alongside increased antibiotic resistance in both E. coli and K. pneumoniae. The period of the COVID-19 pandemic (Phase II) was identified as an independent risk factor for complications in infants with neonatal sepsis.ConclusionCOVID-19 pandemic response measures correlated with a decrease in EOS and an increase in neonatal sepsis complications and antibiotic resistance.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Impacts of COVID-19 pandemic on culture-proven sepsis in neonates

Yang,

Ren,

Gong

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

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“…Higher rates of Staphylococcus aureus and its mortality in COVID-19 patients were also previously reported. Nosocomial transmission may be due to known risk factors, such as intubation and central venous catheters [ 8 , 9 , 49 , 50 ]. Interestingly, although the frequency of Klebsiella pneumoniae bacteremia was notable, its occurrence did not increase along with the CS dose.…”

Section: Discussionmentioning

confidence: 99%

“…In hospitalized COVID-19 patients, a high incidence of bacteremia has been observed by various reports [ 6 , 7 , 8 , 9 , 10 ]. BSIs in this population are associated with lower oxygen saturation, more frequent respiratory failure requiring mechanical ventilation (MV), the development of septic shock, intensive care unit (ICU) admissions, longer hospitalizations, and higher mortality [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients

Papic,

Bistrovic,

Cikara

et al. 2024

Viruses

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COVID-19 patients with severe or critical symptoms are often treated with corticosteroids, per contemporary guidelines. Due to their immunosuppressive and immunomodulatory properties, corticosteroids are associated with the development of superinfections. We aimed to retrospectively assess patterns of corticosteroid use and the profiles of bacterial blood stream infections associated with exposure to different dosing levels, in a cohort of 1558 real-life adult COVID-19 patients. A total of 1391 (89.3%) patients were treated with corticosteroids, with 710 (45.6%) patients receiving low, 539 (34.6%) high and 142 (9.1%) very high corticosteroid doses. Bacteremia developed in a total of 178 (11.4%) patients. The risk of bacteremia was of similar magnitude between the no and low-dose corticosteroid treatments (p = 0.352), whereas it progressively increased with high (OR 6.18, 95% CI (2.66–14.38), p < 0.001) and very high corticosteroid doses (OR 8.12, 95% CI (3.29–20.05), p < 0.001), compared to no corticosteroid treatment. These associations persisted after multivariate adjustments and were present independently of sex, comorbidity burden, and mechanical ventilation. The profiles of individual bacterial pathogens differed depending on the used corticosteroid doses. High and very high corticosteroid doses are frequently used for real-life COVID-19 patients with severe and critical clinical presentations and are associated with a higher risk of bacteremia independently of sex, comorbidity burden, and mechanical ventilation use.

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Lesson from the COVID-19 pandemic lockdown: A major change of hospital-diagnosed bacteremia epidemiology

Cited by 3 publications

References 15 publications

Impacts of COVID-19 pandemic on culture-proven sepsis in neonates

Impacts of COVID-19 pandemic on culture-proven sepsis in neonates

Corticosteroid Dosing Level, Incidence and Profile of Bacterial Blood Stream Infections in Hospitalized COVID-19 Patients

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