Less polar ginsenosides have better protective effects on mice infected by Listeria monocytogenes

Jing, Jinjin; Zhang, Ruoyu; Wang, Yunhai; Tang, Shaojian; Yang, Hanchao; Du, Lidong; Lin, Bingjie; Shao, Lingyun; Zhang, Fengxiang; Peng, Xue

doi:10.1016/j.ecoenv.2021.112065

Cited by 4 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple animal model studies have shown that foodborne pathogens cause intestinal pathological changes by affecting the intestinal epithelial cells, damaging the integrity of the intestinal structure as a result of marked inflammation. − In agreement with previous studies, epithelial crypt depth and goblet cells were reduced along with mononuclear cell infiltration and loss of tight junction proteins (occludin and claudin-2) in the colon of Vp-infected mice. Moreover, this study has shown that the intestine, spleen, and thymus ratios and serum levels of LPS, d -LA, and DAO were markedly increased in the VP group, indicating worsening intestinal epithelial permeability, which may promote pathogen invasion deeper into the internal organs, causing a systemic spread .…”

Section: Discussionsupporting

confidence: 86%

Fish Oil Ameliorates Vibrio parahaemolyticus Infection in Mice by Restoring Colonic Microbiota, Metabolic Profiles, and Immune Homeostasis

Deng

Tan

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

The effect of fish oil (FO) on colonic function, immunity, and microbiota was investigated in Vibrio parahaemolyticus (Vp)-infected C57BL/6J mice. Mice intragastrically presupplemented with FO (4.0 mg) significantly reduced Vp infection as evidenced by stabilizing body weight and reducing disease activity index score and immune organ ratios. FO minimized colonic pathological damage, strengthened the mucosal barrier, and sustained epithelial permeability by increasing epithelial crypt depth, goblet cell numbers, and tight junctions and inhibiting colonic collagen accumulation and fibrosis protein expression. Mechanistically, FO enhanced immunity by decreasing colonic CD3+ T cells, increasing CD4+ T cells, downregulating the TLR4 pathway, reducing interleukin-17 (IL-17) and tumor necrosis factor-α, and increasing immune cytokine IL-4 and interferon-γ levels. Additionally, FO maintained colonic microbiota eubiosis by improving microbial diversity and boosting Clostridium, Akkermansia, and Roseburia growth and their derived propionic acid and butyric acid levels. Collectively, FO alleviated Vp infection by enriching beneficial colonic microbiota and metabolites and restoring immune homeostasis.

show abstract

Section: Discussionsupporting

confidence: 86%

Fish Oil Ameliorates Vibrio parahaemolyticus Infection in Mice by Restoring Colonic Microbiota, Metabolic Profiles, and Immune Homeostasis

Deng

Tan

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Other compounds, like saponins, derived from steroids or triterpenoid glycosides, occur in many plants and affect the microbial cells following the permeabilization of the membrane [2]. As reported by Jing et al, American ginseng saponins and Asian ginseng leaf saponins possessed anti-listeria activity, both in vitro and in mice infected with the pathogens [89].…”

Section: Compounds Exerting Anti-listeria Activity In Plant Extractsmentioning

confidence: 90%

Natural Antimicrobials: A Reservoir to Contrast Listeria monocytogenes

Ricci,

Lazzi,

Bernini

2023

Microorganisms

View full text Add to dashboard Cite

Natural environments possess a reservoir of compounds exerting antimicrobial activity that are forms of defence for some organisms against others. Recently, they have become more and more attractive in the food sector due to the increasing demand for natural compounds that have the capacity to protect food from pathogenic microorganisms. Among foodborne pathogens, Listeria monocytogenes can contaminate food during production, distribution, or storage, and its presence is especially detected in fresh, raw food and ready-to-eat products. The interest in this microorganism is related to listeriosis, a severe disease with a high mortality rate that can occur after its ingestion. Starting from this premise, the present review aims to investigate plant extract and fermented plant matrices, as well as the compounds or mixtures of compounds produced during microbial fermentation processes that have anti-listeria activity.

show abstract

“…The diameter of the Oxford cup used in the test was 8 mm, while the diameter of bacteriostatic zone was >10 mm, which was estimated to exhibit antibacterial activity in vitro . The bacteria inhibition zone diameter of ≤10 mm was judged to have no bacteriostatic effect (Jing et al, 2021).…”

Section: Extraction Methodsmentioning

confidence: 99%

Screening the Chemical Composition and Bioactivity of Cerasus serrulata Flower Extracts Using Two Extraction Methods

Zhang

Zhang²,

Luo

et al. 2023

Pharmacognosy Magazine

View full text Add to dashboard Cite

Background Cerasus serrulata has an excellent antioxidative, antibacterial, and anti-alopecia effect, but its active ingredients and the underlying mechanism are currently unclear, in addition to the fact that the active products vary with the extraction methods. Aim Therefore, this study aims to clarify the active components and antioxidative property of C. serrulata extracted by two different methods (low-temperature vacuum extraction and ethanol extraction) and explore its potential biofunction. Materials and Methods First, the compositions in extracts were characterized by gas chromatographic mass spectrometry (GC-MS) and liquid chromatography-mass spectrography (LC-MS). Then, the antioxidative activity of both extracts was evaluated using free radical scavenging assay (ABTS) and ORAC. Next, the antibacterial activity of both extracts was measured via a bacteriostatic circle experiment. The anti-alopecia effects of both extracts were studied using a mouse model of alopecia. The hematoxylin and eosin (H&E) staining was used to evaluate hair follicles; vascular endothelial-derived growth factor (VEGF) and interleukin-6 (IL-6) expression in mouse skin were evaluated by immunohistochemistry, while β-catenin expression in tissues was used by immunofluorescence. The expression of FGFR and insulin-like growth factor 1 (IGF-1) in the skin was determined to evaluate using real-time quantitative polymerase chain reaction (RT-qPCR). The levels of DHT and 5α-reductase in the experimental mice were determined by ELISA. Results The GC-MS analysis results showed that the extracts were rich in alkanes and aromatic compounds, specifically benzaldehyde, which was the highest component in the cold vacuum extraction, while pipecolic acid was the main component in the ethanol extract. This indicates that C. serrulata has components that exhibit strong inhibitory ability against the growth of five common bacterial strains, expressing excellent free radical scavenging ability. In addition, the active ingredients in C. serrulata were found to significantly deregulate the protein levels in the skin of androgenetic alopecia (AGA) mice, with the levels of IL-6. They were also able to significantly inhibit VEGF reduction. The β-catenin was being significantly upregulated in skin tissue. In addition, FGFR and IGF-1 gene expression also increased. The 5α-reductase and dihydrotestosterone (DHT) can be reduced in the C. serrulata treatment. Conclusion Our data indicate that C. serrulata extract could be beneficial supplements of natural antioxidative, antibacterial, and anti-alopecia agents.

show abstract

Less polar ginsenosides have better protective effects on mice infected by Listeria monocytogenes

Cited by 4 publications

References 48 publications

Fish Oil Ameliorates Vibrio parahaemolyticus Infection in Mice by Restoring Colonic Microbiota, Metabolic Profiles, and Immune Homeostasis

Fish Oil Ameliorates Vibrio parahaemolyticus Infection in Mice by Restoring Colonic Microbiota, Metabolic Profiles, and Immune Homeostasis

Natural Antimicrobials: A Reservoir to Contrast Listeria monocytogenes

Screening the Chemical Composition and Bioactivity of Cerasus serrulata Flower Extracts Using Two Extraction Methods

Contact Info

Product

Resources

About