Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients

Nardo, Davide; Holland, Rachel; Leff, Alexander; Price, Cathy J.; Crinion, Jenny

doi:10.1093/brain/awx234

Cited by 63 publications

(79 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A bilateral frontal network including the right anterior insula, inferior frontal and dorsal anterior cingulate cortices, and the left premotor cortex showed reduced activity for cued as opposed to uncued words from pre-treatment to post-treatment scans for trained versus untrained words, indicating increasing facilitation by speech-sound cueing as a result of treatment. 8 Another key finding is that treatment-induced brain changes are not just related to language processing per se. Treatment success may require brain mechanisms involved in multiple cognitive processes, including determining the salience of stimuli, attending to them and/or regulating cognitive control.…”

Section: Measuring Neuroplasticitymentioning

confidence: 99%

Neuroplasticity and aphasia treatments: new approaches for an old problem

Crosson

Rodriguez

Copland

et al. 2019

J Neurol Neurosurg Psychiatry

Self Cite

View full text Add to dashboard Cite

Given the profound impact of language impairment after stroke (aphasia), neuroplasticity research is garnering considerable attention as means for eventually improving aphasia treatments and how they are delivered. Functional and structural neuroimaging studies indicate that aphasia treatments can recruit both residual and new neural mechanisms to improve language function and that neuroimaging modalities may hold promise in predicting treatment outcome. In relatively small clinical trials, both non-invasive brain stimulation and behavioural manipulations targeting activation or suppression of specific cortices can improve aphasia treatment outcomes. Recent language interventions that employ principles consistent with inducing neuroplasticity also are showing improved performance for both trained and novel items and contexts. While knowledge is rapidly accumulating, larger trials emphasising how to select optimal paradigms for individualised aphasia treatment are needed. Finally, a model of how to incorporate the growing knowledge into clinical practice could help to focus future research.

show abstract

Section: Measuring Neuroplasticitymentioning

confidence: 99%

Neuroplasticity and aphasia treatments: new approaches for an old problem

Crosson

Rodriguez

Copland

et al. 2019

J Neurol Neurosurg Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…An important question is whether the findings on phonological cueing of Pellet Cheneval et al (2018) and Meteyard and Bose (2018) exclude the locus in phonological encoding that Nardo et al (2017) assume. If not, this would reconcile the empirical findings and conclusions about the locus in poststroke aphasia and healthy speakers (Meyer & Schriefers, 1991;Roelofs, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the improvements in aphasia have not only been examined in naming speed and accuracy, but also in neuroimaging studies targeting corresponding changes in brain activations and fibre tract integrity (e.g. Nardo, Holland, Leff, Price, & Crinion, 2017;Van Hees et al, 2014). In these studies, phonological cueing has been central.…”

Section: Introductionmentioning

confidence: 99%

“…In interpreting the treatment effects in their neuroimaging study on poststroke aphasia, Nardo et al (2017) argue that "the phonemic cueing approach used in anomia treatment relies upon the same processes underlying cued-picture naming priming effects found in healthy speakers" (p. 3051), which they take to be phonological encoding processes. This is also assumed by other researchers for phonological facilitation in poststroke aphasia (Best et al, 2013;Hashimoto & Thompson, 2010;Nickels, 2002) and primary progressive aphasia (Mack et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Next, the computer simulation methods are explained. Then, I report the results of simulations targeting the immediate and long-term treatment effects of auditory phonological cueing in behavioural and neural measures observed by Nardo et al (2017) as well as the behavioural findings on immediate effects of Pellet Cheneval et al (2018) and Meteyard and Bose (2018).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phonological cueing of word finding in aphasia: insights from simulations of immediate and treatment effects

Roelofs

2019

Aphasiology

View full text Add to dashboard Cite

Background: Difficulties with word finding occasionally occur in all speakers and commonly in all aphasia types. An understanding of these difficulties and their treatment-induced improvement is of fundamental scientific and clinical importance. Phonological cueing yields immediate and treatment effects in behavioural and neural measures. Disagreement exists about the locus of the cueing effects in aphasia and whether the effects arise from the same neurocognitive mechanisms as phonological effects in picture naming by healthy speakers. Aims: Computer simulations were conducted to expand our understanding of immediate and treatment effects on word finding in behavioural and neural measures and to examine whether a unified account of the phonological effects in health and disease is possible. Methods & Procedure: Picture naming performance of the WEAVER computer model, which accounts for immediate phonological effects in healthy speakers, was assessed in simulations of immediate and treatment effects of phonological cueing in poststroke aphasia. The model assumes (1) a phonological encoding locus of the cueing effects, (2) a cohort mechanism in cue perception, and (3) activation of lexical and sublexical phonological levels by the cues. Outcomes & Results: The model successfully simulated the empirically observed effects in behavioural naming performance and neural measures. Conclusions: The simulations provide a proof of concept for the idea that immediate and treatment effects of phonological cueing in aphasia arise from the same neurocognitive mechanisms as immediate phonological effects in healthy speakers. This expands our understanding of word finding, associated difficulties, and their improvement by therapy.

show abstract

Cerebral perfusion mediated by thalamo‐cortical functional connectivity in non‐dominant thalamus affects naming ability in aphasia

Zhang

Zhou

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

Naming is a commonly impaired language domain in various types of aphasia. Emerging evidence supports the cortico‐subcortical circuitry subserving naming processing, although neurovascular regulation of the non‐dominant thalamic and basal ganglia subregions underlying post‐stroke naming difficulty remains unclear. Data from 25 subacute stroke patients and 26 age‐, sex‐, and education‐matched healthy volunteers were analyzed. Region‐of‐interest‐wise functional connectivity (FC) was calculated to measure the strength of cortico‐subcortical connections. Cerebral blood flow (CBF) was determined to reflect perfusion levels. Correlation and mediation analyses were performed to identify the relationship between cortico‐subcortical connectivity, regional cerebral perfusion, and naming performance. We observed increased right‐hemispheric subcortical connectivity in patients. FC between the right posterior superior temporal sulcus (pSTS) and lateral/medial prefrontal thalamus (lPFtha/mPFtha) exhibited significantly negative correlations with total naming score. Trend‐level increased CBF in subcortical nuclei, including that in the right lPFtha, and significant negative correlations between naming and regional perfusion of the right lPFtha were observed. The relationship between CBF in the right lPFtha and naming was fully mediated by the lPFtha‐pSTS connectivity in the non‐dominant hemisphere. Our findings suggest that perfusion changes in the right thalamic subregions affect naming performance through thalamo‐cortical circuits in post‐stroke aphasia. This study highlights the neurovascular pathophysiology of the non‐dominant hemisphere and demonstrates thalamic involvement in naming after stroke.

show abstract

Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients

Cited by 63 publications

References 81 publications

Neuroplasticity and aphasia treatments: new approaches for an old problem

Neuroplasticity and aphasia treatments: new approaches for an old problem

Phonological cueing of word finding in aphasia: insights from simulations of immediate and treatment effects

Cerebral perfusion mediated by thalamo‐cortical functional connectivity in non‐dominant thalamus affects naming ability in aphasia

Contact Info

Product

Resources

About