Less collagen production in smokers

Jørgensen, Lars N.; Kallehave, Finn; Christensen, Ernst; Siana, Jørn Ege; Gottrup, Finn

doi:10.1016/s0039-6060(98)70167-9

Cited by 289 publications

(157 citation statements)

References 18 publications

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“…Wang et al [36] suggest that smoking alters the biosynthesis of collagen and extracellular matrix turnover, and decreases corneal thickness, which is a risk factor for POAG. [36] Smoking has been reported to decrease the production of oxygen and collagen in tissues during wound healing, [37,38] deteriorating the ocular hypoxia. [36] Zanon-Moreno et al [39] suggest that smoking liberates free radicals that cause damage in the trabecular meshwork, consequently decreasing the outflow of the aqueous humor.…”

Section: Discussionmentioning

confidence: 99%

Smoking and incidence of glaucoma

et al. 2017

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Smoking is a serious global public health concern that has been related to many chronic diseases. However, the effect of smoking on eye disorders has been less studied. The aim of this cohort study was to assess the association between current tobacco smokers and the risk of developing glaucoma and furthermore to evaluate the relationship between passive or former smokers and glaucoma.In this prospective and dynamic cohort, 16,797 participants initially who were found not to have glaucoma were followed up for a median of 8.5 years. Validated data on lifestyle, including tobacco consumption, were assessed at baseline. Information about new diagnosis of glaucoma was collected by follow-up questionnaires every 2 years. The outcome was the incidence of self-reported glaucoma during the follow-up. A subsample was used to validate the glaucoma diagnosis.During the 8.5 years of follow-up, 184 new glaucoma cases were identified. Current smokers had a significantly higher risk of glaucoma compared to participants who had never smoked after controlling for potential confounders (Hazard ratio [HR] 1.88 [95% coefficient interval (CI): 1.26–2.81]; P = 0.002). A nonsignificant increased risk was found among former smokers (HR 1.27 [95% CI: 0.88–1.82]; P = 0.198). When we assessed the exposure as per the number of cigarette pack-years, a dose–response relationship between pack-years and the risk of glaucoma was found (HR for the 5th quintile versus the 1st quintile: 1.70 [95% IC: 1.10–2.64], P for trend, 0.009). However, no relationship was found between passive smokers and glaucoma. (HR 0.67 [95% CI: 0.37–1.21]; P = 0.189).Our results suggest a direct association between current smokers and the incidence of glaucoma. In particular, this association was related to the number of pack-years, which was not found in the case of former smokers nor in the case of passive smokers.

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Section: Discussionmentioning

confidence: 99%

Smoking and incidence of glaucoma

et al. 2017

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“…The amount of collagen deposition and repair at the wound was negatively correlated with the consumption of tobacco. 96 Ichinose et al. has also demonstrated alterations in biomechanical properties of the supraspinatus tendon in the setting of nicotine, producing increased elastic modulus of the supraspinatus tendon in a rat model, an indicator for increased stiffness which is more predisposed to injury.…”

Section: Smokingmentioning

confidence: 97%

What is the Role of Systemic Conditions and Options for Manipulation of Bone Formation and Bone Resorption in Rotator Cuff Tendon Healing and Repair?

Lee

Gumucio

Mendias

et al. 2017

Techniques in Shoulder &Amp; Elbow Surgery

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Rotator cuff pathology is a significant cause of shoulder pain. Operative repair of rotator cuff is an established standard of care for these patient, however, failure of the procedure is common. Systemic conditions such as diabetes mellitus, hypocholesteremia, thyroid disease, and smoking significantly affect the outcomes of rotator cuff repair and have significant implications for the management of these patients. Diabetes mellitus has been proposed to damage tendons through non-enzymatic glycosylation of collagen with advanced glycation end product formation and impaired microcirculation. Hypocholesteremia may lead to fatty infiltration and subsequent pro-inflammatory degenerative enzymatic degeneration. Thyroid disease may disrupt tendon homeostasis through the alteration of collagen production and the accumulation of glycosaminoglycans. Lastly, smoking inhibits tendon healing through the induction of hypovascularity and hypoperfusion. Understanding of the implications these systemic conditions have on the outcomes is important in the management of rotator cuff disease.

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“…59,60,64 Collagen is the primary structural protein that affects a healing wound’s tensile strength and research has demonstrated that its production is diminished in smokers. 65 …”

Section: Smoking and Wound Healingmentioning

confidence: 99%

Smoking, Chronic Wound Healing, and Implications for Evidence-Based Practice

McDaniel

Browning

2014

Journal of Wound, Ostomy &Amp; Continence Nursing

125

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Chronic wounds are rising in prevalence and creating significant socioeconomic burdens for patients and healthcare systems worldwide. Therefore, it is now more important than ever that clinicians follow evidence-based guidelines for wound care when developing personalized treatment plans for their patients with chronic wounds. Evidence-based guidelines for treating venous leg ulcers, diabetic foot ulcers, and pressure ulcers, the 3 main categories of chronic wounds, focus primarily on biologic therapies. However, there are also evidence-based guidelines for treating behavioral risks to poor healing, such as smoking, which should be incorporated into treatment plans when appropriate. The purpose of this article was to review the mechanisms through which smoking adversely impacts the wound healing process, and propose strategies for incorporating evidence-based guidelines for treating tobacco dependence into treatment plans for patients with chronic wounds who smoke.

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Less collagen production in smokers

Cited by 289 publications

References 18 publications

Smoking and incidence of glaucoma

Smoking and incidence of glaucoma

What is the Role of Systemic Conditions and Options for Manipulation of Bone Formation and Bone Resorption in Rotator Cuff Tendon Healing and Repair?

Smoking, Chronic Wound Healing, and Implications for Evidence-Based Practice

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