Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon?

Christie, Lesley; Evans, Alan; Bray, Susan E.; Smith, Mark E.; Kernohan, Neil M.; Levison, David A.; Goodlad, John

doi:10.1016/j.humpath.2005.08.024

Cited by 82 publications

(61 citation statements)

References 17 publications

(18 reference statements)

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“…There is evidence that different mechanisms may exist in different patients. [5][6][7] The biology of cases with a clonal relationship are of particular interest in understanding the lineage connection of these distinct cell types and the possible future impact on treatment of these diseases.…”

Section: Discussionmentioning

confidence: 99%

“…2,4 The biologic relationship of LC histiocytosis with hematologic neoplasms remains to be fully elucidated. In some instances, LC histiocytosis appears to be incidentally associated without evidence of dissemination or progression, 5 whereas in others the LC histiocytosis follows an aggressive course. 6 A clonal relationship between LC histiocytosis and T-lymphoblastic leukemia has been shown in a limited number of cases; 6,7 however, to our knowledge, a clonal relationship has not been demonstrated in LC histiocytosis associated with other acute leukemias.…”

mentioning

confidence: 99%

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Langerhans cell histiocytosis in acute leukemias of ambiguous or myeloid lineage in adult patients: support for a possible clonal relationship

et al. 2014

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Four patients presented with acute leukemia of ambiguous or myeloid lineage in association with Langerhans cell histiocytosis and provide evidence suggesting a common origin of the two neoplasms. One patient had a non-constitutional trisomy 21 in both the leukemic blasts and the Langerhans cells indicative of a clonal relationship. A second case expressed CD2, CD13, and CD117 on both the Langerhans cells and the blasts suggesting a possible clonal relationship. All four cases exhibited geographic intermingling of the Langerhans cell histiocytosis and acute leukemia and shared unique features including extramedullary leukemia involving lymph nodes in all cases with Langerhans cell histiocytosis only present in sites involved by acute leukemia. T-cell antigen expression was present in all cases with one meeting criteria for mixed phenotype acute leukemia, T/myeloid, not otherwise specified. These findings support the concept that coexistent Langerhans cell histiocytosis and acute leukemia is clonally related in some cases. Furthermore, these cases of acute myeloid or acute leukemia of ambiguous lineage with Langerhans cell histiocytosis share some unique features suggesting a common underlying neoplastic hematopoietic stem cell.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Langerhans cell histiocytosis in acute leukemias of ambiguous or myeloid lineage in adult patients: support for a possible clonal relationship

et al. 2014

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“…Molecular genetic analysis revealed germline TCR β and γ chain genes. Christie et al [24] investigated 5 examples of LCH-like proliferations occurring in the context of other lymphoproliferative disorders with the highly polymorphic human androgen receptor gene assay. Their results showed that, at least in a proportion of cases, Langerhans cells may represent reactive proliferation.…”

Section: Discussionmentioning

confidence: 99%

Unique Composite Hematolymphoid Tumor Consisting of a Pro-T Lymphoblastic Lymphoma and an Indeterminate Dendritic Cell Tumor: Evidence for Divergent Common Progenitor Cell Differentiation

et al. 2014

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Until recently, hematopoietic neoplasms were considered monoclonal proliferations belonging to one cell lineage. In the last years, evidence for transdifferentiation from one cell lineage to another or divergent common progenitor cell differentiation has accumulated, mainly based on composite hematolymphoid tumors, sharing common genetic abnormalities. We report the case of a 59-year-old woman with a composite pro-T lymphoblastic lymphoma (LBL) and indeterminate dendritic cell tumor infiltrating the lymph nodes, bone marrow and stomach. Genetic analyses revealed that both cell populations bore +21, while a G13D mutation of the NRAS gene and monosomy 18 were detected only in the pro-T LBL. The synchronous appearance of two distinct uncommon hematolymphoid tumors in the same patient, recurrent at three different anatomic locations, with an identifiable common genetic denominator, namely +21, but also with unique genetic anomalies in the pro-T LBL raises the hypothesis of a divergent common progenitor cell differentiation.

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“…We presumed that the LC collections were of polyclonal reactive nature. This is based on the concept presented in the WHO classification of tumors of the hematopoietic and lymphoid tissues [6,13], which describes an association of Langerhans cell histiocytosis exclusively with T-lymphoblastic leukemia; excess of LC in other types of hematopoietic malignancies was regarded as polyclonal and assumed to be reactive [13][14][15][16]. Moreover, we looked actively for extensive LC infiltrates in a group of lymphoma cases with abundant CD68+ histiocytes.…”

Section: Discussionmentioning

confidence: 99%

“…Isolated reports determined the clonality of LC by using the human androgen receptor gene assay. They demonstrated polyclonality of LC infiltrates in lymphomas exhibiting this association [5,6].…”

Section: Introductionmentioning

confidence: 91%

High content of Langerhans cells in malignant lymphoma—incidence and significance

et al. 2010

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We describe 25 patients, 14 with classical Hodgkin lymphoma and 11 with non-Hodgkin lymphoma, in all of whom an excess of Langerhans cells was evident. Except for the first three cases, in which the excess of Langerhans cells was identified on routine slides, the remaining cases were disclosed by actively investigating lymphomas with excess of CD68+ histiocytes and performing CD1a and S-100 protein immunostains. Although no clonality study was performed on the Langerhans cells, we endorse the view which states that in the above association, the Langerhans cells are polyclonal. Fourteen cases of Hodgkin lymphoma with a large number of Langerhans cells were identified in a cohort of 231 classical Hodgkin lymphomas. We compared the features of classical Hodgkin lymphoma with abundant Langerhans cells with those without Langerhans cells. Our analysis reveals that Hodgkin lymphoma with Langerhans cell excess shows greater LMP1/EBV expression (P = .007) and lower p53 expression (P = .042) in the Hodgkin-Reed-Sternberg cells but is not associated with a poorer outcome.

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Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon?

Cited by 82 publications

References 17 publications

Langerhans cell histiocytosis in acute leukemias of ambiguous or myeloid lineage in adult patients: support for a possible clonal relationship

Langerhans cell histiocytosis in acute leukemias of ambiguous or myeloid lineage in adult patients: support for a possible clonal relationship

Unique Composite Hematolymphoid Tumor Consisting of a Pro-T Lymphoblastic Lymphoma and an Indeterminate Dendritic Cell Tumor: Evidence for Divergent Common Progenitor Cell Differentiation

High content of Langerhans cells in malignant lymphoma—incidence and significance

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