Lesions of Uncertain Differentiation

Degryse, H; Vanhoenacker, Filip

doi:10.1007/3-540-30792-3_23

Cited by 2 publications

(3 citation statements)

References 53 publications

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“…These features can lead to misdiagnoses and grade CCS as nonaggressive lesions (74). On T1w, most CCS (about 52%) have a slightly increased SI compared with muscle, while they are hyperintense to muscle on T2w (67, 74). Because of paramagnetic effects of intralesional melanin, high SI on T1w and lower SI on T2w should theoretically be present (74).…”

Section: Tumors Of Uncertain Differentiationmentioning

confidence: 99%

“…Areas of more prominent adipose tissue have also been described at the poles of the lesion and they appear as a hyperechoic triangular cap, termed “the bright cap sign” (63). On MRI, IM presents as a well‐circumscribed, homogeneous mass with SI lower than or equal to muscle on T1w and brighter than fat on T2w (67). Myxomas show an intense heterogeneous contrast‐enhancement, although they are composed of bland spindle cells with an avascular highly myxoid stroma; moreover, myxomas are poorly vascularized, typically with capillary‐like vessels (Fig.…”

Section: Tumors Of Uncertain Differentiationmentioning

confidence: 99%

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Hox‐mediated regulation of doublesex sculpts sex‐specific abdomen morphology in Drosophila

Wang

Yoder

2012

Developmental Dynamics

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Background: Hox transcription factors are deeply conserved proteins that guide development through regulation of diverse target genes. Furthermore, alteration in Hox target cis-regulation has been proposed as a major mechanism of animal morphological evolution. Crucial to understanding how homeotic genes sculpt the developing body and contribute to the evolution of form is identification and characterization of regulatory targets. Because target specificity is achieved through physical or genetic interactions with cofactors or co-regulators, characterizing interactions between homeotic genes and regulatory partners is also critical. In Drosophila melanogaster, sexually dimorphic abdominal morphology results from sex-specific gene regulation mediated by the Hox protein Abdominal-B (Abd-B) and products of the sex-determination gene doublesex (dsx). Together these transcription factors regulate numerous sex-specific characters, including pigmentation, cuticle morphology, and abdominal segment number. Results: We show Dsx expression in the developing D. melanogaster pupal abdomen is spatiotemporally dynamic, correlating with segments that undergo sexually dimorphic morphogenesis. Furthermore, our genetic analyses show Dsx expression is Abd-B dependent. Conclusions: Doublesex and Abd-B are not only requisite co-regulators of sexually dimorphic abdominal morphology. We propose that dsx is itself a transcriptional target of Abd-B. These data present a testable hypothesis about the evolution of sexually dimorphic segment number in Diptera.

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Section: Tumors Of Uncertain Differentiationmentioning

confidence: 99%

Section: Tumors Of Uncertain Differentiationmentioning

confidence: 99%

Hox‐mediated regulation of doublesex sculpts sex‐specific abdomen morphology in Drosophila

Wang

Yoder

2012

Developmental Dynamics

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“…Since hyperintensity on T1w (compared with muscle) is rarely seen in STS, it is quite an important finding to narrow down differential diagnoses (74). Hyperintensity on T2w could be caused by a low nucleo‐cytoplasmic index, by abundance of loose connective tissue between the cellular nests, or by high amount of myxoid stroma found in these hyperintense lesions (67). As with synovial sarcoma and epithelioid sarcoma, intimate association with a tendon may provide a clue to the diagnosis (Table 9) (71).…”

Section: Tumors Of Uncertain Differentiationmentioning

confidence: 99%

Imaging of soft‐tissue tumors

Stramare

Beltrame

Gazzola

et al. 2012

Magnetic Resonance Imaging

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The objective of this review is to highlight the major imaging characteristics of the main soft-tissue sarcoma histotypes observed in the group "Sarcomi" of the Istituto Oncologico Veneto in the last 5 years. A literature review was performed using PubMed and textbooks. Radiological imaging can guide the diagnosis for the subset of lesions that have typical clinical and imaging features. Soft-tissue tumors are common in clinical practice and a systematic clinical and imaging approach may guide the diagnosis.

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Lesions of Uncertain Differentiation

Cited by 2 publications

References 53 publications

Hox‐mediated regulation of doublesex sculpts sex‐specific abdomen morphology in Drosophila

Hox‐mediated regulation of doublesex sculpts sex‐specific abdomen morphology in Drosophila

Imaging of soft‐tissue tumors

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