Lesions of the SDN-POA inhibit sexual behavior of male wistar rats

Jonge, F.H. de; Louwerse, Annet L.; Ooms, M. P.; Evers, Paul; Endert, E.; Poll, Nanne E. van de

doi:10.1016/0361-9230(89)90194-9

Cited by 194 publications

(82 citation statements)

References 36 publications

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“…As mentioned previously, the size of the SDN-MPO is positively correlated with male sexual behavior in rats and sheep; [24][25][26][27][28][29][30][31] therefore, the reduction in volume of the sexually dimorphic Nissl arom clusters in the male ArKO mouse, which resemble the rat SDN-MPO, may correlate with the lack of sexual behavior (or sexual motivation) previously reported. 23 It has been well established that SDN volume in rats is significantly and positively correlated to male sexual behavior.…”

Section: Discussionsupporting

confidence: 63%

“…25,28 In addition, bilateral lesions over the SDN region have resulted in reduced male sexual behavior. 32 This holds true for nonsexually experienced rats 27 and rats with prior sexual experience, although only in lesions covering the dorsal SDN region. 24 In addition, prenatal and pre-plus neonatal treatment with the aromatase inhibitor ATD, reduced SDN volume in male rats, and accordingly, sexual behavior measures such as frequency of mounts, Sexually dimorphic cell groups in MPO of 129SvEv RA Hill et al intromission and ejaculation were all reduced upon pre-plus neonatal ATD treatment, 28 thus demonstrating an estrogenic component in regulating the volume of the SDN and the control of male sexual behavior, which is consistent with our current findings in the male ArKO mouse.…”

Section: Discussionmentioning

confidence: 93%

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Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

2008

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The current study describes the presence of sexually dimorphic cell groups within the MPO of the 129SvEv, but not the C57BL/6J strain of mice. We detected galanin-positive clusters of cells located in the MPO of 129SvEv and C57BL/6J mice, with sex differences found only in the 129SvEv strain. Aromatase-positive and dense Nissl-counterstained clusters of cells were identified only in the MPO of 129SvEv mice, but not in the C57BL/6J strain. Furthermore, this study has demonstrated that the volume of these sexually dimorphic cell groups is regulated by estrogen, but not testosterone, as male aromatase knockout mice (which have high levels of testosterone, but no estrogen) show reduced cell group volumes. These structural changes, which occur in an estrogen-deficient state may influence male sexual behaviors.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 93%

Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

2008

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“…Small lesions to this region did not impair copulatory behavior, although larger preoptic lesions (which spared the AVPV) decreased male copulatory patterns in that study [8]. Another group reported that SDN-POA lesions in male rats decreased the percentage of animals that ejaculated in a mating test, and increased latencies to mount, intromit, or ejaculate [41]. Although an exact homolog of the SDN-POA may not exist in other species, there is evidence for sexual dimorphism of the anterior hypothalamus and preoptic area in other species that have been studied [152,22,111,2], making the SDN-POA of the rat a valuable comparative model.…”

Section: Sexually Dimorphic Nucleus Of the Preoptic Area (Sdn-poa)mentioning

confidence: 69%

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

Gore¹

2008

Frontiers in Neuroendocrinology

230

122

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The ability of a species to reproduce successfully requires the careful orchestration of developmental processes during critical time points, particularly the late embryonic and early postnatal periods. This article begins with a brief presentation of the evidence for how gonadal steroid hormones exert these imprinting effects upon the morphology of sexually differentiated hypothalamic brain regions, the mechanisms underlying these effects, and their implications in adulthood. Then, I review the evidence that aberrant exposure to hormonally-active substances such as exogenous endocrine-disrupting chemicals (EDCs), may result in improper hypothalamic programming, thereby decreasing reproductive success in adulthood. The field of endocrine disruption has shed new light on the discipline of basic reproductive neuroendocrinology through studies on how early life exposures to EDCs may alter gene expression via non-genomic, epigenetic mechanisms, including DNA methylation and histone acetylation. Importantly, these effects may be transmitted to future generations if the germline is affected via transgenerational, epigenetic actions. By understanding the mechanisms by which natural hormones and xenobiotics affect reproductive neuroendocrine systems, we will gain a better understanding of normal developmental processes, as well as to develop the potential ability to intervene when development is disrupted.

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“…Several experiments were therefore designed to investigate whether this cell group plays a role in the control of copulatory behavior but, despite the fact that large mPOA/MPN lesions severely disrupt copulatory behavior (as reviewed previously), more discrete lesions specifically destroying the SDN-POA do not seem to affect copulatory behavioral expression in the male [9] (see [143] for review). Transient behavioral deficits were however observed following lesions of the SDN-POA in sexually inexperienced rats [58] and similar lesions also disrupted the expression of male-typical behavior in females [144]. Taken together, available data suggest that relatively large lesions of the mPOA (involving at least parts of the MPN) are required to eliminate copulatory behavior in male rats but no critical sub-group of neurons has been identified as being particularly more important than any other subgroup.…”

Section: The Preoptic Neuronal Circuit Controlling Male Sexual Behavimentioning

confidence: 89%

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

191

168

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Several studies have suggested dissociations between neural circuits underlying the expression of appetitive (i.e. sexual motivation) and consummatory components (i.e., copulatory behavior) of vertebrate male sexual behavior. The medial preoptic area (mPOA) clearly controls the expression of male copulation but, according to a number of experiments, is not necessarily implicated in the expression of appetitive sexual behavior. In rats for example, lesions to the mPOA eliminate maletypical copulatory behavior but have more subtle or no obvious effects on measures of sexual motivation. Rats with such lesions still pursue and attempt to mount females. They also acquire and perform learned instrumental responses to gain access to females. However, recent lesions studies and measures of the expression of the immediate early gene c-fos demonstrate that, in quail, subregions of the mPOA, in particular of its sexually dimorphic component the medial preoptic nucleus, can be specifically linked with either the expression of appetitive or consummatory sexual behavior. In particular more rostral regions can be linked to appetitive components while more caudal regions are involved in consummatory behavior. This functional sub-region variation is associated with neurochemical and hodological specializations (i.e. differences in chemical phenotype of the cells or in their connectivity), especially those related to the actions of androgens in relation to the activation of male sexual behavior, that are also present in rodents and other species. It could thus reflect general principles about POA organization and function in the vertebrate brain.

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Lesions of the SDN-POA inhibit sexual behavior of male wistar rats

Cited by 194 publications

References 36 publications

Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

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