Lesions of the mitochondrial genome and ways of its preservation

Gasiev, A. I.; Shaikhaev, G. O.

doi:10.1134/s1022795408040017

Cited by 2 publications

(3 citation statements)

References 141 publications

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“…Mitochondrial biogenesis program in heart can exhibit adaptive remodeling following biomechanical and oxidative stress, to protect myocardium metabolism [29]. The transcriptional coacti- vator PGC-1, and especially PGC-1a and PGC-1 beta, are important regulation factors of mitochondrial biosynthesis and energy metabolism [30]- [33]. NRF-1 can turn on the mitochondrial TFA gene; in turn, mtTFA gene can activate gene which produces mitochondria [31]- [33].…”

Section: Comparisons On the Ct Value Of Gsk-3β In Myocardial Tissue Omentioning

confidence: 99%

“…The transcriptional coacti- vator PGC-1, and especially PGC-1a and PGC-1 beta, are important regulation factors of mitochondrial biosynthesis and energy metabolism [30]- [33]. NRF-1 can turn on the mitochondrial TFA gene; in turn, mtTFA gene can activate gene which produces mitochondria [31]- [33]. Abnormalities in mitochondrial biogenesis can lead to cardiac dysfunction.…”

Section: Comparisons On the Ct Value Of Gsk-3β In Myocardial Tissue Omentioning

confidence: 99%

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The Mechanism of <i>Cornus officinalis</i> Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

Chen¹,

Li²,

Chen³

et al. 2016

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Objective: To investigate effects of Cornus officinalis Total Glycosides (COTG) and Cornus Polysaccharide (CP) on myocardial protection and on expression of mitochondria biogenesis related gene of acute myocardial infarction (AMI) rats, Materials and Methods: Ninety-six SD rats of SPF level were randomly divided into 5 groups: sham operation group, model group, preventive treatment group, COTG treatment group, CP treatment group, and there were 12 cases in each one. By legating the left anterior descending branch of coronary artery method, acute myocardial infarction model was established. The rat of sham operation group and model group was intragastric administered with physiological saline; other groups were given with corresponding drugs. The cardiac function, the myocardial infarct area, the expression of mitochondrial biogenesis genes such as PGC-1α, PGC-1β, NRF-1mRNA and GSK-3β mRNA, GSK-3β Protein Expression were analyzed. Results: The results revealed that compared with model group, myocardial infarction size, LVDs, LVDd, LVESV, LVEDP, and −dp/dt decreased; LVSP increased in preventive treatment group, COTG treatment group, and CP treatment group (p < 0.05); LVEDV increased in preventive treatment group (p < 0.05), PGC 1 alpha, and PGC 1 beta; the NRF-1 mRNA expression increased in preventive treatment group, COTG treatment group, and CP treatment group (p < 0.05). Compared with CP and COTG treatment group, PGClpha, beta PGC 1, the NRF-1 mRNA expression increased in preventive treatment group (p < 0.05). Compared with the sham operation group, GSK-3 beta mRNA and protein expression increased in model group, preventive treatment group, COTG treatment group, and CP treatment group (p < 0.05). Compared with model group, GSK-3 beta mRNA expression reduced in preventive treatment group, COTG treatment group, and CP treatment group (p < 0.05). Conclusions: Cornus officinalis total glycosides and Cornus polysaccharides can effectively * Corresponding author. K. Chen et al. 46 protect myocardial mitochondria of acute myocardial infarction rats by activating GSK-3β signaling pathways, and reduce the myocardial infarct size, which has great significance for improving cardiac function.

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Section: Comparisons On the Ct Value Of Gsk-3β In Myocardial Tissue Omentioning

confidence: 99%

Section: Comparisons On the Ct Value Of Gsk-3β In Myocardial Tissue Omentioning

confidence: 99%

The Mechanism of <i>Cornus officinalis</i> Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

Chen¹,

Li²,

Chen³

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Nowadays, the interest in several aspects of the mitochondrial genome is growing exponentially (Gasiev and Shaikhaev, 2008). The mitochondrial genome is commonly used to infer a metazoan phylogeny, haploid status, and genes that are conserved and of small size, all of which are important factors for solving systematic and evolutionary questions in a wider taxonomic context (Sinniger, et al, 2007;Waeschenbach et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Morfologia e taxonomia molecular de Myxosporea (Myxobolidae) e Monogenea (Dactylogyridae) de brâquias de pacu em pisciculturas de São Paulo, Brasil

Müller¹,

Ueta²

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Dedico à minha família, em especial aos meus pais Claudinei Müller e Sonia T. M. Müller, pelo apoio e por todo estímulo, a quem sempre dedicarei minhas conquistas. Aos meus irmãos Giuliano Ricardo Müller e Ana Rita Müller, por toda ajuda e carinho. vii Agradecimentos À Deus, por tudo, sem Sua força divina nada seria possível. À Professora Doutora Marlene Tiduko Ueta pela orientação, apoio, carinho e por sempre acompanhar de perto o desenvolvimento deste trabalho com muita dedicação.

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Lesions of the mitochondrial genome and ways of its preservation

Cited by 2 publications

References 141 publications

The Mechanism of <i>Cornus officinalis</i> Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

The Mechanism of <i>Cornus officinalis</i> Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

Morfologia e taxonomia molecular de Myxosporea (Myxobolidae) e Monogenea (Dactylogyridae) de brâquias de pacu em pisciculturas de São Paulo, Brasil

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Lesions of the mitochondrial genome and ways of its preservation

Cited by 2 publications

References 141 publications

The Mechanism of &lt;i&gt;Cornus officinalis&lt;/i&gt; Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

The Mechanism of &lt;i&gt;Cornus officinalis&lt;/i&gt; Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

Morfologia e taxonomia molecular de Myxosporea (Myxobolidae) e Monogenea (Dactylogyridae) de brâquias de pacu em pisciculturas de São Paulo, Brasil

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Resources

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The Mechanism of <i>Cornus officinalis</i> Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction

The Mechanism of <i>Cornus officinalis</i> Total Glycosides and Cornus Polysaccharide on Myocardial Protection in Rats with Acute Myocardial Infarction