Lesions of the caruncle: A clinicohistopathologic study

Luthra, C L; Doxanas, Marcos T.; Green, W R

doi:10.1016/0039-6257(78)90155-8

Cited by 100 publications

(78 citation statements)

References 8 publications

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“…Table 1 shows the relative frequency of caruncular lesions in this study and in previously reported large series. In the majority of studies, 9,11,13 as in this study, nevi constituted the largest group of caruncular lesions (average of 45.8%, range: 33.7-59.5% of lesions). However, other authors found a preponderance of papillomas 6,7,10 or epithelial cysts 8 in lesions removed from the caruncle.…”

Section: Discussionmentioning

confidence: 99%

“…Since 1854, when von Graefe 5 reported the first series of lesions of the caruncle, only a few reviews have been published, the majority of them reported more than 15 years ago. 3,[6][7][8][9][10][11][12][13] In our series, caruncular lesions represented only 0.4% of all surgical specimens submitted to our Ophthalmic Pathology Laboratory during the 18 years of the study. This incidence is in agreement with the incidences previously reported (0.3-1.1%).…”

Section: Discussionmentioning

confidence: 99%

“…This incidence is in agreement with the incidences previously reported (0.3-1.1%). [9][10][11]13 Thirteen different histopathological types of lesions were identified in our series. This diversity is explained based on all the different tissues forming the caruncle.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 A squamous caruncular horn with gradual enlargment in a 3-month infant has been described. 30 On the basis of the similarities between this case and the tusks of elephants, the authors suggested that the caruncle can be a vestigial remnant of the upper incisor of lower animals.…”

Section: Epithelial Lesionsmentioning

confidence: 99%

“…8 Other rare epithelial cysts described in the caruncle are apocrine hidrocystoma 9 and steatocystoma. 46,47 In the former, the cyst is lined by an inner layer of low cuboidal secretory cells and an outer row of slightly flattened myoepithelial cells.…”

Section: Cystsmentioning

confidence: 99%

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Lesions of the caruncle: a description of 42 cases and a review of the literature

Levy

Ilsar

Deckel

et al. 2008

Eye

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Lesions of the caruncle are uncommon. On account of the histological composition of the caruncle, which includes, in addition to conjunctiva, hair follicles, sebaceous glands, sweat glands, and accessory lacrimal tissue, the caruncle may develop lesions that may be similar to those found in the skin, conjunctiva, or lacrimal gland. Clinical preoperative diagnosis is very difficult and reached only in about half of the cases. The vast majority of lesions of the caruncle are benign, mainly nevi. Reported malignant lesions are very rare but can be potentially fatal. Although malignancy is clinically overestimated, any suspected malignant lesion should be excised and examined histopathologically by an experienced pathologist. This study presents the clinical and histological data of 42 consecutive caruncular lesions processed at our laboratory and reviews previously reported cases of caruncular lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Epithelial Lesionsmentioning

confidence: 99%

Section: Cystsmentioning

confidence: 99%

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Lesions of the caruncle: a description of 42 cases and a review of the literature

Levy

Ilsar

Deckel

et al. 2008

Eye

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An Uncommon Malignant Neoplasm of the Caruncle

Lam

To²,

Fan³

et al. 1998

Arch Ophthalmol

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Immunophenotype of Conjunctival Melanomas

et al. 2002

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Objective: To characterize the immunophenotypic expression pattern of conjunctival melanomas, with the use of standard melanoma markers as well as microphthalmia transcription factor and p75 neurotrophin receptor.Design: Eleven conjunctival melanomas, including 1 caruncular melanoma, were immunolabeled with a panel of antibodies that included S100, tyrosinase, melan-A, HMB-45 and HMB-50 combination, microphthalmia transcription factor, and p75 neurotrophin receptor. The results were tabulated on the basis of intensity and pervasiveness of labeling and compared with a previous study of uveal melanomas.Results: Immunolabeling with S100 was at significantly higher levels in conjunctival melanomas than in uveal melanomas. Tyrosinase, HMB-45 and HMB-50 combination, melan-A, and microphthalmia transcription factor were expressed at high levels in conjunctival melanomas, whereas p75 neurotrophin receptor was not expressed.Conclusions: Melanomas of the conjunctiva, including the caruncle, expressed S100, tyrosinase, melan-A, HMB-45 and HMB-50 combination, and microphthalmia transcription factor at high levels, suggesting that these are good markers for this melanoma subtype. Expression of S100 was significantly higher in conjunctival melanomas than in uveal melanomas. The immunophenotypic pattern of conjunctival melanomas is most similar to the epithelioid subtype of cutaneous melanomas.

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Lesions of the caruncle: A clinicohistopathologic study

Cited by 100 publications

References 8 publications

Lesions of the caruncle: a description of 42 cases and a review of the literature

Lesions of the caruncle: a description of 42 cases and a review of the literature

An Uncommon Malignant Neoplasm of the Caruncle

Immunophenotype of Conjunctival Melanomas

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