Lesions of supracallosal or infracallosal hippocampal pathways in the rat: Behavioral, neurochemical, and histochemical effects

Jeltsch, Hélène; Cassel, J.C.; Jackisch, Rolf; Neufang, B.; Greene, Paul L.; Kelche, Christian; Hertting, G.; Will, Bruno

doi:10.1016/s0163-1047(05)80033-0

Cited by 39 publications

(40 citation statements)

References 32 publications

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“…These findings are in line with previous reports (Cassel et al 1991;Greene et al 1994;Jeltsch et al 1994a). The only overall effect induced by the GM1 treatment was a further increase in nocturnal home cage activity.…”

Section: Discussionsupporting

confidence: 94%

Behavioral effects of GM1 ganglioside treatment and intrahippocampal septal grafts in rats with fimbria-fornix lesions

1997

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The monosialoganglioside GM1 is a compound with neurotrophic properties found to foster functional recovery in various paradigms of brain damage. The present experiment examined whether systemic treatment with GM1 may facilitate behavioral recovery in rats with fimbria-fornix lesions and intrahippocampal grafts rich in cholinergic neurons. Among 68 Long-Evans female rats, 46 sustained a bilateral electrolytic lesion of the fimbria and the dorsal fornix and 22 were sham-operated. Fourteen days later, half the lesioned rats were subjected to intrahippocampal grafts of a fetal septal cell suspension. Starting a few hours after lesion surgery and over a 2-month period, half the rats of each surgical treatment group received a daily injection of GM1 (30 mg/kg i.p.), the other half being injected with saline as a control. All rats were subsequently tested for locomotor activity and radial maze learning. The lesions induced locomotor hyperactivity and impaired learning performances in both an uninterrupted and an interrupted radial maze testing procedure. In all rats with surviving grafts, the grafts had provided the hippocampus with a new and dense organotypic acetylcholinesterase-positive innervation pattern which did not differ between saline- and GM1-treated subjects. The scores/performances of the rats that had received only the grafts or only the GM1 treatment did not differ significantly from those of their respective lesion-only counterparts. However, in the radial-arm maze task, the grafted rats given GM1 showed improved learning performances as compared with their saline-treated counterparts: they used more efficient visit patterns under the uninterrupted testing conditions and made fewer errors under the interrupted ones. The results suggest that GM1 treatment or intrahippocampal grafts used separately do not attenuate the lesion-induced behavioral deficits measured in this experiment. However, when GM1 treatment and grafts are used conjointly, both may interact in a manner allowing part of these deficits to be attenuated.

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Section: Discussionsupporting

confidence: 94%

Behavioral effects of GM1 ganglioside treatment and intrahippocampal septal grafts in rats with fimbria-fornix lesions

1997

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“…Shute and Lewis (1963) and Fibiger (1982) have concluded that AChE-intense neurons in the medial septal and diagonal band nuclei project via the fimbria-fornix to the hippocampus. Further evidence that the fimbria-fornix provides major cholinergic input to the hippocampus was demonstrated by Jeltsch et al (1994), in which fimbria-fornix lesions reduced cholinergic markers by ∼70% in the dorsal hippocampus.…”

Section: Histological Resultsmentioning

confidence: 93%

“…The tract made by the electrode only slightly damaged the supracallosal septohippocampal pathways and cortex. Previous work with rats has demonstrated that the supracallosal damage does not produce additional impairments on spatial tasks (Sutherland and Rodriguez 1989;Jeltsch et al 1994). Stains for acetylcholinesterase (AChE) revealed extensive depletion of AChE in the hippocampus (Fig.…”

Section: Histological Resultsmentioning

confidence: 94%

Fimbria-Fornix Lesions Disrupt the Dead Reckoning (Homing) Component of Exploratory Behavior in Mice

Gorny¹,

Gorny²,

Wallace³

et al. 2002

Learn. Mem.

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Exploration is the primary way in which rodents gather information about their spatial surroundings. Thus, spatial theories propose that damage to the hippocampus, a structure thought to play a fundamental role in spatial behavior, should disrupt exploration. Exploration in rats is organized. The animals create home bases that are central to exploratory excursions and returns, and hippocampal formation damage alters the organization of exploration by disrupting returns. Mice do not appear to readily establish home bases in novel environments, thus, for this species, it is more difficult to establish the contribution of the hippocampus to exploration. The purpose of the present study was threefold: develop a task in which mice center their exploration from a home base, determine whether the exploratory behavior is organized, and evaluate the role of fimbria-fornix lesions on exploration. Mice were given a novel exploratory task in which their nesting material was placed on a large circular table. Video records of control and fimbria-fornix mice were made in both light and dark (infrared light) conditions. Exploration patterns (outward trips, stops, and homeward trips) were reconstructed from the video records. Control mice centered their activity on their bedding, from which they made circuitous outward trips marked by many stops, and periodic direct returns. The bedding-centered behavior and outward trips of the fimbria-fornix mice were similar to those of the control mice, but significantly fewer direct return trips occurred. The direct homeward trips observed under light and dark conditions were consistent with a dead-reckoning strategy, in which an animal computes its present position and homeward trajectory from self-movement cues generated on the outward trip. Because the fimbria-fornix lesions disrupted the homeward component of exploratory trips, we conclude that the fimbria-fornix may contribute to dead reckoning in mice. The results also show that the home-bedding methodology facilitates the establishment of a home base by mice, thus providing a useful methodology for studies with mice.

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“…This test was chosen because previous studies had demonstrated that systemic or central administration of the non-subtype-selective muscarinic antagonist, scopolamine (Bartolini et al, 1992;Givens and Olton, 1995), or disruption of septohippocampal pathways (Jeltsch et al, 1994) reduces choice accuracy in different versions of the T-maze test. T-maze experiments were performed with food-restricted mice, using food pellets placed at the ends of the two arms of the T-maze for food reinforcement.…”

Section: Performance In the T-maze Delayed Alternation Taskmentioning

confidence: 99%

M₂Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity

Seeger¹,

Федорова²,

Zheng³

et al. 2004

J. Neurosci.

189

139

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Muscarinic acetylcholine receptors are known to play key roles in facilitating cognitive processes. However, the specific roles of the individual muscarinic receptor subtypes (M 1 -M 5 ) in learning and memory are not well understood at present. In the present study, we used wild-type (M2 ϩ/ϩ ) and M 2 receptor-deficient (M2 Ϫ/Ϫ mice. Because impaired muscarinic cholinergic neurotransmission is associated with Alzheimer's disease and normal aging processes, these findings should be of considerable therapeutic relevance.

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Lesions of supracallosal or infracallosal hippocampal pathways in the rat: Behavioral, neurochemical, and histochemical effects

Cited by 39 publications

References 32 publications

Behavioral effects of GM1 ganglioside treatment and intrahippocampal septal grafts in rats with fimbria-fornix lesions

Behavioral effects of GM1 ganglioside treatment and intrahippocampal septal grafts in rats with fimbria-fornix lesions

Fimbria-Fornix Lesions Disrupt the Dead Reckoning (Homing) Component of Exploratory Behavior in Mice

M₂Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity

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Lesions of supracallosal or infracallosal hippocampal pathways in the rat: Behavioral, neurochemical, and histochemical effects

Cited by 39 publications

References 32 publications

Behavioral effects of GM1 ganglioside treatment and intrahippocampal septal grafts in rats with fimbria-fornix lesions

Behavioral effects of GM1 ganglioside treatment and intrahippocampal septal grafts in rats with fimbria-fornix lesions

Fimbria-Fornix Lesions Disrupt the Dead Reckoning (Homing) Component of Exploratory Behavior in Mice

M2Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity

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M₂Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity