Lesions of Cardiac Conduction Tissue in Rheumatoid Aortitis

Sobin, Leslie H.; Hagstrom, Jack W. C.

doi:10.1001/jama.1962.03050140003001

Cited by 22 publications

(3 citation statements)

References 9 publications

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“…The small branches of the coronary arteries, including the nodal artery, were involved in the chronic inflammatory process. Though there was no clinical evidence of collagen disease the pathological changes in the heart were similar to those described in scleroderma and ankylosing spondylitis (Bernstein, 1951;Sobin and Hagstrom, 1962;Lev et al, 1966;Weed et al, 1966). One patient, in addition, had an old occlusion of the right coronary artery and an old posterior wall infarct not involving the septum or the artery to the AV node.…”

Section: Av Ansupporting

confidence: 52%

Aetiology of chronic heart block. A clinico-pathological correlation in 65 cases.

Harris¹,

Davies²,

Redwood³

et al. 1969

Heart

101

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Section: Av Ansupporting

confidence: 52%

Aetiology of chronic heart block. A clinico-pathological correlation in 65 cases.

Harris¹,

Davies²,

Redwood³

et al. 1969

Heart

101

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“…In all but four of these patients with heart block, none of whom were necropsied, there was also aortic incompe- tence suggesting that there is usually an accompanying aortitis. This correlates with the cases of spondylitis recorded by Weed, Kulander, Mazzarella, and Decker (1966) and by Sobin and Hagstrom (1962) in which there was nonspecific chronic inflammatory destruction of the atrioventricular conducting tissue in continuity with aortic inflammation. It seems possible that the proximity of the aortic valve to the atrioventricular conducting tissue, combined with the susceptibility of the aortic valve to inflammation in ankylosing spondylitis (Clark, Kulka, and Bauer, 1957), determines the apparent risk of heart block in this disease, rather than there being a specific susceptibility of the conducting tissue to the disease process.…”

Section: Discussionsupporting

confidence: 86%

Rheumatoid heart disease with complete heart block

Harris

1970

J Clin Pathol

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“…Electrocardiographic changes may occur alone or in association with aortic incompetence in ankylosing spondylitis (Ansell and others, 1958;Sobin and Hagstrom, 1962), Reiter's disease (Csonka, Litchfield, Oates, and Willcox, 1961;Rodnan, Benedek, Shaver, and Fennell, 1964), and rheumatoid arthritis (Gowans, 1960;Hoffman and Leight, 1965). The usual abnormality is prolongation ofthe PR interval; complete heart block is rare (Julkunen and Luomanmdki, 1964).…”

Section: Discussionmentioning

confidence: 99%

Scleritis and aortic incompetence. Two manifestations of connective tissue disease.

Pitkeathly¹,

Howitt²,

Lyne³

1970

Annals of the Rheumatic Diseases

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From the Departments of Rheumatism Research and Cardiology, Manchester Royal Infirmary, and the Manchester Royal Eye HospitalScleritis is known to occur as a manifestation of connective tissue disease, particularly rheumatoid arthritis and polyarteritis nodosa (Manschot, 1961).In a recent study of 31 patients with scleritis (Lyne and Pitkeathly, 1968), evidence of connective tissue disease was found in fourteen (45 per cent.). Since this study was completed, we have encountered a further three patients presenting with scleritis in whom aortic incompetence was found. Two had severe aortic regurgitation and complete atrioventricular (AV) block. The third had a diffuse arteritis, and the aortic incompetence was only a minor feature of this illness.Case reports Case 1, a 56-year-old housewife, gave a 5-year history of almost continuous inflammation affecting the left eye with severe pain at times. The right eye had never been involved. For 2 years she had complained of breathlessness, weakness, tiredness, and light-headedness on exertion. During the previous few months, she had experienced episodes of dizziness and had lost consciousness on several occasions. Examination The abnormalities were confined to the left eye and the cardiovascular system.The perilimbal sclera of the left eye showed diffuse thinning for about 2 mm. all round. The sclera elsewhere was thickened by a subconjunctival granulomatous-like infiltration. A fairly severe uveitis was present. There was elevation of the retina on the temporal side subjacent to the site of the most intense inflammation.The pulse was regular, collapsing in type, and the rate 38/min. The blood pressure was 220/40 mm. Hg. A hyperdynamic left ventricular impulse was palpable. There was a short aortic ejection systolic murmur and a moderately long aortic diastolic murmur. The aortic second sound was diminished.

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Lesions of Cardiac Conduction Tissue in Rheumatoid Aortitis

Cited by 22 publications

References 9 publications

Aetiology of chronic heart block. A clinico-pathological correlation in 65 cases.

Aetiology of chronic heart block. A clinico-pathological correlation in 65 cases.

Rheumatoid heart disease with complete heart block

Scleritis and aortic incompetence. Two manifestations of connective tissue disease.

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