Lesion Volume Estimation from TBI–MRI

Abstract

Traumatic brain injury (TBI) is a major problem affecting millions of people around the world every year. Usually, TBI results from any direct or indirect physical impact, sudden jerks, or blunt impacts to the head, leading to damage to the brain. Current research in TBI is focused on analyzing the biological and behavioral states of patients prone to such injuries. This paper presents a technique applied on MRI images in estimation of lesion volumes in brain tissues of traumatic brain-injured laboratory rats that were subjected to controlled cortical impacts. The lesion region in the brain tissue is estimated using segmentation of the brain, diffusion, and the damage regions. After the segmentation, the area of the damaged portion is estimated across each slice of MRI and the combined volume of damage is estimated through 3D reconstruction.