Lesion-induced dissociations between appetitive and consummatory grooming behaviors and their relationship to body weight and food intake rhythms.

Randall, Walter; Lakso, Virginia; Liittschwager, John M.

doi:10.1037/h0027640

Cited by 17 publications

(6 citation statements)

References 20 publications

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“…Although overly simplistic to reduce a behaviour as complex as feeding to a series of molecular interactions ( 34 ) , extensive research into the effect of hypothalamic lesions in the 1940s, 1950s and 1960s ( 35 – 38 ) and the discovery of numerous peptides has provided a greater understanding of factors produced in peripheral tissues that alter feeding behaviour. Over the last decade in particular, important advances have been made in the characterisation of hypothalamic neuronal networks and neuropeptide transmitters, along with the discovery of circulating peptides that send signals to the brain regarding the body's nutritional status ( 39 ) .…”

Section: Physiological Factors Regulating Intakementioning

confidence: 99%

Neuroendocrine and physiological regulation of intake with particular reference to domesticated ruminant animals

et al. 2008

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The central nervous system undertakes the homeostatic role of sensing nutrient intake and body reserves, integrating the information, and regulating energy intake and/or energy expenditure. Few tasks regulated by the brain hold greater survival value, particularly important in farmed ruminant species, where the demands of pregnancy, lactation and/or growth are not easily met by often bulky plant-based and sometimes nutrient-sparse diets. Information regarding metabolic state can be transmitted to the appetite control centres of the brain by a diverse array of signals, such as stimulation of the vagus nerve, or metabolic 'feedback' factors derived from the pituitary gland, adipose tissue, stomach/abomasum, intestine, pancreas and/or muscle. These signals act directly on the neurons located in the arcuate nucleus of the medio-basal hypothalamus, a key integration, and hunger (orexigenic) and satiety (anorexigenic) control centre of the brain. Interest in human obesity and associated disorders has fuelled considerable research effort in this area, resulting in increased understanding of chronic and acute factors influencing feed intake. In recent years, research has demonstrated that these results have relevance to animal production, with genetic selection for production found to affect orexigenic hormones, feeding found to reduce the concentration of acute controllers of orexigenic signals, and exogenous administration of orexigenic hormones (i.e. growth hormone or ghrelin) reportedly increasing DM intake in ruminant animals as well as single-stomached species. The current state of knowledge on factors influencing the hypothalamic orexigenic and anorexigenic control centres is reviewed, particularly as it relates to domesticated ruminant animals, and potential avenues for future research are identified.

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Section: Physiological Factors Regulating Intakementioning

confidence: 99%

Neuroendocrine and physiological regulation of intake with particular reference to domesticated ruminant animals

et al. 2008

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“…Compared with the rat, the cat may be less suitable for tests of food and water regulation in the later stages of recovery. In addition to being finicky eaters, cats show large rhythmic variations in their caloric intake and body weight over the course of the year (Randall & Lakso, 1968;Randall, Lakso, & Liittschwager, 1969;Randall & Parsons, 1969;Skultety, 1966). These variations covary with fluctuations in thyroid activity and may reflect long-term metabolic rhythms in cats (Randall & Lakso, 1968;Randall & Liittschwager, 1967).…”

mentioning

confidence: 99%

Role of activation and sensory stimuli in recovery from lateral hypothalamic damage in the cat.

Wolgin

Teitelbaùm²

1978

Journal of Comparative and Physiological Psychology

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The early stages of recovery from lateral hypothalamic lesions were analyzed in 30 adult cats. In addition to aphagia and adipsia, neurological examination revealed deficits suggestive of deficient endogenous arousal, including somnolence, catalepsy, akinesia, and sensory neglect. Manipulations (tail pinch and injection of amphetamine) that counteracted these deficits also restored feeding. During recovery from aphagia, feeding gradually became activated by sensory stimuli (sight, feel, and smell) associated with food. These data suggest that activation is an important component in the control of normal feeding.

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“…F tests are then used to arrive at a single curve that best describes any existing periodicity. Complete details of the steps involved in the selection of a single curve to represent a given set of data, as well as illustrative examples, have been reported elsewhere (e.g., Bliss, 1958Bliss, , 1970Randall & Liitsschwager, 1967;Randall et al, 1969;Randall, 1970;Randall & Parsons, 1972;Johnson & Randall, 1985).…”

Section: Mathematical and Statistical Proceduresmentioning

confidence: 98%

An abnormal annual rhythm in adrenaline excretion and grooming reflexes in cats with pontile lesions

Parsons

Randal

1986

Journal of Interdisiplinary Cycle Research

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Cats with pontile lesions exhibit grooming reflexes (e.g., the scratch reflex), and the receptive field for the grooming reflexes (the area on the body surface whose stimulation elicits the grooming reflexes) systematically varies in size, exhibiting long-term rhythmic changes during a year. Several lines of evidence suggested that the rhythms in adrenaline may be altered in the cats with lesions and underlie the changes in the size of the receptive field. Therefore, the size of the receptive field for grooming reflexes and adrenomedullary function (as measured by the urinary excretion of adrenaline) were monitored for one year in eight normal cats and six cats with pontile lesions. Periodic regression, analysis of variance, and correlational methods revealed a lesion-induced change in the annual adrenaline rhythm. No changes in amplitude or overall mean value were detected, but the annual peak in adrenaline excretion occurred approximately four months late, in June instead of February. The abnormality in the adrenaline rhythm was inversely and significantly correlated with the size of the receptive field for the grooming reflexes. Chronopathological changes in rhythmic parameters are discussed as important considerations in the behavioral abnormalities which appear following lesions of the central nervous system.

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Lesion-induced dissociations between appetitive and consummatory grooming behaviors and their relationship to body weight and food intake rhythms.

Cited by 17 publications

References 20 publications

Neuroendocrine and physiological regulation of intake with particular reference to domesticated ruminant animals

Neuroendocrine and physiological regulation of intake with particular reference to domesticated ruminant animals

Role of activation and sensory stimuli in recovery from lateral hypothalamic damage in the cat.

An abnormal annual rhythm in adrenaline excretion and grooming reflexes in cats with pontile lesions

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