Lesion in Scalp and Skull as the First Manifestation of Hepatocellular Carcinoma

Ferraz, Vinicius Ricieri; Araújo, João Luiz Vitorino; Sementilli, Leonardo; Neto, José Ferreira da Silva; Veiga, José Carlos Esteves

doi:10.1155/2016/2897048

Cited by 11 publications

(29 citation statements)

References 13 publications

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“…Characteristic, although rare, locations of solitary cutaneous metastases are the scalp and the umbilicus [5]. Cutaneous metastases, although rare, must be among the differential diagnosis of skin lesions and that a diagnostic research based on these findings can be conducted [8].…”

Section: Discussionmentioning

confidence: 99%

Potpourri of interesting scalp lesions

Hegde

Samartha

2019

Trop J Pathol Microbiol

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Introduction: Painless soft tissue masses on the scalp are commonly encountered in clinical practice. The most likely diagnoses still remain as epidermoid cysts, sebaceous cysts and benign lipomas. The aim of this study is to exhibit the vast variety of scalp lesions, with emphasis on the metastatic scalp lesions. Materials and Methods: This was a retrospective study carried out in the Department of Pathology in a tertiary care hospital in coastal Karnataka, India. A total of 29 scalp lesions received during the period were included in the study. Paraffin blocks and slides along with case records were retrieved and studied. Results: Out of a total of 29 scalp lesions included in this study, the most common lesion was lipoma. The most interesting cases were the 5 cases of scalp lesions which were metastasis from visceral organs, the most common site being the thyroid. Conclusion: A wide histopathological range of lesions comprising of neoplastic and non-neoplastic lesions were found. The most common lesion in this study was lipoma, while the most interesting were metastatic scalp lesions.

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Section: Discussionmentioning

confidence: 99%

Potpourri of interesting scalp lesions

Hegde

Samartha

2019

Trop J Pathol Microbiol

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“…In rare cases, they may manifest as lesions in the scalp and skull. 12,13 The incidence rate is about 9 to 17%, based on various studies, although the exact incidence is thought to be higher.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous meningioma and brain metastasis from renal cell carcinoma – a rare presentation. Case report

et al. 2017

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CONTEXT: Brain metastases are the most common tumors of the central nervous system. Because of their high frequency, they may be associated with rare situations. Among these are tumor-to-tumor metastasis and an even a rarer situation called simultaneous brain tumors, which are more related to primary tumors of the reproductive and endocrine systems. CASE REPORT: A 56-year-old male patient with a history of renal cell carcinoma (which had previously been resected) presented with a ventricular lesion (suggestive of metastatic origin) and simultaneous olfactory groove lesion (probably a meningioma). First, only the ventricular lesion was dealt with, but after a year, the meningothelial lesion increased and an occipital lesion appeared. Therefore, both of these were resected in a single operation. All the procedures were performed by the same neurosurgeon. The patient evolved without neurological deficits during the postoperative period. After these two interventions, the patient remained well and was referred for adjuvant treatment.CONCLUSIONS: This study provides the first description of an association between these two tumors. Brain metastases may be associated with several lesions, and rare presentations such as simultaneity with meningioma should alert neurosurgeons to provide the best oncological treatment. RESUMO CONTEXTO:As metástases cerebrais são os tumores mais comuns do sistema nervoso central e, devido à sua elevada frequência, podem estar associadas a situações raras. Entre estas estão as "tumor to tumor metastasis" e uma situação ainda mais rara chamada de tumores cerebrais simultâneos, mais relacionados a tumores primários dos sistemas endocrinológico e reprodutivo. RELATO DE CASO: Um homem de 56 anos com histórico de câncer de células renais (extirpado previamente) apresentou-se com lesão ventricular (sugestiva de origem metastática) e simultaneamente com uma lesão em topografia de goteira olfatória (provavelmente meningioma). Primeiramente, apenas a lesão ventricular foi abordada, porém após um ano, a lesão meningotelial aumentou e uma lesão occipital apareceu e então ambas foram ressecadas em uma única cirurgia. Todos os procedimentos foram realizados pelo mesmo neurocirurgião. O paciente evoluiu sem déficits neurológicos no período pós-operatório. Após essas duas intervenções, o paciente permaneceu bem, sendo encaminhado para tratamento adjuvante. CONCLUSÕES: O presente trabalho é a primeira descrição da associação encontrada entre esses dois tumores. As metástases cerebrais podem associar-se a várias lesões, e manifestações raras, tais como apresentação simultânea com meningioma, devem alertar o neurocirurgião a fornecer o melhor tratamento oncológico.

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“…According to gender distribution of primary tumours, we obviously found that the 100% of patients with uterus cancer (8/ 8) 64,65,84 while in 24.8% (30/121) cases, the diagnosis was synchronous. 7,8,18,20,23,31,33,35,44,46,48,56,68,69,72,73,[76][77][78]81,84,87,93,95,96,99,102,110,111 The specific sites of primary tumours in each of these subgroups were reported in Table S1 (Supporting Information). Considering cases diagnosed after the primary tumour, they were mainly derived from breast and GI cancers (18/88 cases each); synchronous cases prevalently had a GI origin (10/30 cases), while cases diagnosed before the primary tumour were only three (one from GI, namely one thyroid and one lung cancer).…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

“…Regarding clinical appearance, AN was identified as a nodule, plaque and patch in 58% (69/119), 8,9,21,22,24,27,33,34,37-41,43,44,46,47,49- 2,6,7,11,[14][15][16][17][18][19][20]23,25,29,67,96 respectively; under the general term of a 'mass' in 16.8% (20/119) 28,32,35,42,45,48,58,59,71,73,80,81,83,87,95,106,110,111,114,117 and as an 'excoriated lesion' in 2.5% (3/119) of cases. 69,78,109 Specifically, breast cancer was mainly associated with patch lesions (9/20), followed by plaques and nodules (five and five out of 20, respectively).…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

“…10,30,37,44,52,56,66,77 When reported, AN was asymptomatic in the majority of cases (78%; 21/27), with pain being reported in 22% of cases (6/27 cases). 21,32,42,56,69,117 According to the site on the scalp, in the majority of cases (70/94) only one site was involved, being the parietal area the most frequently reported with 19 cases, 30,31,33,35,45,48,50,55,69,78,[92][93][94][95]104,106,107,110,116 followed by the frontal with 18 cases, 2,[7][8][9]16,38,42,44,52,65,[80][81][82]98,114,[117][118]…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

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Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Paolino

Pampena

Grassi

et al. 2019

Acad Dermatol Venereol

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Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression‐free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

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Lesion in Scalp and Skull as the First Manifestation of Hepatocellular Carcinoma

Cited by 11 publications

References 13 publications

Potpourri of interesting scalp lesions

Potpourri of interesting scalp lesions

Simultaneous meningioma and brain metastasis from renal cell carcinoma – a rare presentation. Case report

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

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