Lesion and electrical stimulation of the ventral tegmental area modify persistent nociceptive behavior in the rat

Role of dopamine D2-like receptors within the ventral tegmental area and nucleus accumbens in antinociception induced by lateral hypothalamus stimulation

“…Several studies have shown that the ACC integrate the information of the affective component of pain, this area was also able to inhibit neuropathic nociception [18,45,46]. It can also be suggested that activation of VTA neurons by orexins causes inhibitory effects on the ACC [45,46], and can diminish nociception via a descending pathway that involves the periaqueductal gray matter [46].…”

Pharmacological modulation of brain activity in a preclinical model of osteoarthritis

“…3C, the trends in functional connectivity across the 4 cohorts are given for the NAcc_L-ventral tegmental area (VTA). The VTA was chosen given its direct connectivity with the NAcc and its role in nociception and chronic pain (Sotres-Bayon et al, 2001). As can be observed in Figs.…”

Tactile Sensory and Pain Networks in the Human Spinal Cord and Brain Stem Mapped by Means of Functional MR Imaging

“…The substantia nigra is a lateral extension of the ventral tegmental area and has been shown to be involved in pain suppression and the affective component of pain. 5,37,38 Descending Modulation Activity in the spinal cord, PAG, and raphe nuclei with the 15 g filament is expected to indicate descending pain modulation. The PAG receives ascending projections from the spinomesencephalic tract, spinoreticular pathway, and descending projections from the amygdala, cortex, and hypothalamus.…”