Are β-blockers anesthestics?

Yang, Homer; Fayad, Ashraf

doi:10.1007/bf03018700

Cited by 17 publications

(16 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[4142] This concept has raised concerns pertaining to BIS attenuation and “masking” of hemodynamic parameters resulting in “light anesthesia” and hence awareness with intraoperative esmolol administration. [26] Nonetheless, BIS was utilized in the studies evaluating the anesthetic-sparing effects of esmolol, and no changes in the anesthetic depth were reported. [37] BIS was not uniformly employed across the included trials.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of perioperative esmolol on early postoperative pain: A systematic review and meta-analysis

Watts

Thiruvenkatarajan

Calvert

et al. 2017

J Anaesthesiol Clin Pharmacol

View full text Add to dashboard Cite

Esmolol has been shown to improve postoperative pain and reduce opioid requirements. The aim of this systematic review was to evaluate the effect of perioperative esmolol as an adjunct on early postoperative pain intensity, recovery profile, and anesthetic requirement. Databases were searched for randomized placebo-controlled trials evaluating the effects of esmolol during general anesthesia. Primary outcomes were related to early postoperative pain whereas secondary outcomes were related to emergence time, postoperative nausea and vomiting, and intraoperative anesthetic requirement. Nineteen trials were identified involving 936 patients (esmolol = 470, placebo = 466). In esmolol group, numeric pain scores at rest in the immediate postoperative period were reduced by 1.16 (95% confidence interval [CI]: 1.97–0.35, I2 = 96.7%) out of 10. Opioid consumption was also decreased in the postanesthesia care unit compared with placebo, mean difference of 5.1 mg (95% CI: 7.0–3.2, I2 = 96.9%) morphine IV equivalents; a 69% reduction in opioid rescue dosing was noted (odds ratio [OR]: 0.31, 95% CI: 0.16–0.80, I2 = 0.0%). A 61% reduction in postoperative nausea and vomiting was also evident (OR: 0.39, 95% CI: 0.20–0.75, I2 = 60.7%). A reduction in propofol induction dose was noted in the esmolol group (mean difference: −0.53 mg/kg, 95% CI: −0.63–−0.44, I2 = 0.0%). A decrease in end-tidal desflurane equivalent (mean difference: 1.70%, 95% CI: −2.39–−1.02, I2 = 92.0%) and intraoperative opioid usage (fentanyl equivalent, mean difference: 440 μg, 95% CI: −637–−244, I2 = 99.6%) was observed in esmolol group. Esmolol had no effect on the emergence time. Perioperative esmolol as an adjunct may reduce postoperative pain intensity, opioid consumption, and postoperative nausea vomiting. Given the heterogeneity, larger clinical trials are warranted to confirm these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[2026] A limited meta-analysis comparing perioperative esmolol to opioid showed a reduction in postoperative nausea and vomiting (PONV) and discharge time but no effect on postoperative opioid requirement. [3]…”

Section: Introductionmentioning

confidence: 99%

The effect of perioperative esmolol on early postoperative pain: A systematic review and meta-analysis

Watts

Thiruvenkatarajan

Calvert

et al. 2017

J Anaesthesiol Clin Pharmacol

View full text Add to dashboard Cite

show abstract

“…The finding is similar to that of Menigaux et al [4], who administered esmolol. Yang and Fayad [20] commented that there is evidence to suggest that β-blockers have significant effects on the central nervous system and that it is plausible that β-blockers potentiate the "hypnosis part" of anesthesia [20], but it is unknown whether landiolol has a similar effect in humans.…”

Section: Discussionmentioning

confidence: 98%

Intravenous landiolol, a novel β1-adrenergic blocker, reduces the minimum alveolar concentration of sevoflurane in women

Wajima

Tsuchida

Shiga

et al. 2011

Journal of Clinical Anesthesia

View full text Add to dashboard Cite

“…[27] This effect can theoretically precipitate awareness by masking the signs of “light anesthesia.”[28] BIS was used in two of the three studies that were included in our analysis on volatile anesthetic requirement. [23] None of them reported an increase of BIS in the esmolol group.…”

Section: Discussionmentioning

confidence: 99%

The effect of esmolol compared to opioids on postoperative nausea and vomiting, postanesthesia care unit discharge time, and analgesia in noncardiac surgery: A meta-analysis

Thiruvenkatarajan

Watts

Calvert

et al. 2017

J Anaesthesiol Clin Pharmacol

View full text Add to dashboard Cite

Are β-blockers anesthestics?

Cited by 17 publications

References 42 publications

The effect of perioperative esmolol on early postoperative pain: A systematic review and meta-analysis

The effect of perioperative esmolol on early postoperative pain: A systematic review and meta-analysis

Intravenous landiolol, a novel β1-adrenergic blocker, reduces the minimum alveolar concentration of sevoflurane in women

The effect of esmolol compared to opioids on postoperative nausea and vomiting, postanesthesia care unit discharge time, and analgesia in noncardiac surgery: A meta-analysis

Contact Info

Product

Resources

About