Les tumeurs musculaires lisses de l’utérus

Rammeh-Rommani, Soumaya; Mokni, Moncef; Stita, Wided; Trabelsi, Amel; Hamissa, S; Sriha, Badreddine; Tahar-Yacoubi, M; Korbi, S.

doi:10.1016/s0368-2315(05)82881-9

Cited by 11 publications

(7 citation statements)

References 7 publications

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“…LM is the most common type which occurs in nearly 40% of women older than 35 years. Uterine LMSs are relatively rare smooth muscle tumors, accounting to approximately one third of uterine sarcomas and 1.3% of all uterine malignancies [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors

2012

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BackgroundThe diagnosis of uterine smooth muscle tumors depends on a combination of microscopic features. However, a small number of these tumors still pose difficult diagnostic challenges.AimTo investigate progesterone receptor (PR) and p53 expression in leiomyomas (LMs), atypical leiomyomas (ALMs), smooth muscle tumors of uncertain malignant potential (STUMP), and leiomyosarcomas (LMSs) and to evaluate the potential utility of the selected immunohistochemical markers in differentiating these tumors.Materials and methodsImmunohistochemical expression of PR and p53 was investigated in 41 uterine smooth muscle tumors comprising: 15 LMS, 4 STUMP, 6 ALM and 16 LM. Quantitative evaluation of PR and p53 expression was graded on a scale from 0 to 3+.ResultsLeiomyosarcomas showed reduced PR expression. All LMs as well as ALMs and STUMP were stained intensely for PR. Conversely, LMS was strongly stained with p53, while the three non-sarcomatous groups (STUMP, ALM, LM) were either entirely negative or weakly stained for p53. Regarding both PR and p53 expression, the difference between the LMS group and the three non-sarcomatous groups was highly significant (p < 0.001). Combined high PR - low p53 expression was seen in all the 26 examined cases of the non-sarcomatous group including the STUMP cases and none of the LMS cases. Therefore, it represents a "benign" profile with 100% specificity in diagnosis of a non-sarcomatous tumor.ConclusionImmunohistochemistry for PR and p53 is valuable as an adjunct tool to morphological assessment of problematic uterine smooth muscle tumors.

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Section: Introductionmentioning

confidence: 99%

“…The ultimate biological behavior of tumors classified as STUMP remains uncertain. Thus, it would be clinically valuable to decrease the percentage of these cases for the optimal management of the patients [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors

2012

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“…The most common type, LM, occurs in nearly 40% of women older than 35 years. Uterine LMSs are relatively rare smooth muscle tumors and account for about one third of uterine sarcomas and 1.3% of all uterine malignancies [2].…”

Section: Introductionmentioning

confidence: 99%

“…This term is used when there is some significant doubt about the failure probability associated with a particular combination of microscopic features. [2,3].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Characterization of Genes Expressed in Leiomyoma using Ki67 and P53 in Patient Attending Niger Delta University Teaching Hospital

Eruvwahwe

Edison

Alaba

et al. 2021

JCTI

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Objectives: This study aimed to investigate the expressions of p53 and ki67 genes in the characterization of leiomyomas. Materials: Fifty (50) Paraffin embedded tissue blocks were selected from the department of Histopathology, Niger Delta University Teaching Hospital, Okolobri from January 2011 to August 2019. The histological characterization and morphological evaluation were defined using the routine Hematoxylin and Eosin staining method. Immunostaining was done for p53 and ki67 using the manufacturers antibodies. Results: A direct correlation between age and the expression of the p53 gene was also made in this study. It was observed that in patients within the ages of 50-59 and 60-69, there was markedly no expression of the p53 gene whereas in patients within the ages of 20-29, there was still some level of expression (20%) and ages 30-39 (80%) and finally 40-49 (10%). There was no expression (0.0%) of Ki-67 in uterine leiomyomas across all age groups. Conclusion; This study therefore has suggested that based on the percentage of expression, it can rightly be inferred that the p53 gene is a good indicator in the immune-histochemical characterization of leiomyomas as it has good sensitivity and good prognosis as opposed to Ki67.

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“…Despite the fact that UFs represent more than 99% of all uterine smooth muscle cell tumors [ 14 ], the etiology of UFs is barely understood. Our understanding of UF disease and the development of medical therapies for UFs is severely hampered by the lack of in vivo models for this disease.…”

Section: Introductionmentioning

confidence: 99%

Application of a Patient Derived Xenograft Model for Predicative Study of Uterine Fibroid Disease

et al. 2015

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Human uterine fibroids, benign tumors derived from the smooth muscle layers of the uterus, impose a major health burden to up to 50% of premenopausal women in their daily life. To improve our understanding of this disease, we developed and characterized a patient-derived xenograft model by subcutaneous transplantation of pieces of human uterine fibroid tissue into three different strains of severe combined immunodeficient mice. Engrafted uterine fibroid tissue preserved the classical morphology with interwoven bundles of smooth muscle cells and an abundant deposition of collagenous matrix, similar to uterine fibroids in situ. The grafts expressed both estrogen receptor 1 and progesterone receptor. Additionally, both receptors were up-regulated by estrogen treatment. Growth of the fibroid grafts was dependent on 17β-estradiol and progesterone supplementation at levels similar to women with the disease and was studied for up to 60 days at maximum. Co-treatment with the antiprogestin mifepristone reduced graft growth (four independent donors, p<0.0001 two-sided t-test), as did treatment with the mTOR inhibitor rapamycin (three independent donors, p<0.0001 two-sided t-test). This in vivo animal model preserves the main histological and functional characteristics of human uterine fibroids, is amenable to intervention by pharmacological treatment, and can thus serve as an adequate model for the development of novel therapies.

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Les tumeurs musculaires lisses de l’utérus

Cited by 11 publications

References 7 publications

Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors

Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors

Immunohistochemical Characterization of Genes Expressed in Leiomyoma using Ki67 and P53 in Patient Attending Niger Delta University Teaching Hospital

Application of a Patient Derived Xenograft Model for Predicative Study of Uterine Fibroid Disease

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