Les sites métastatiques atypiques des cancers de la prostate

Lebrét, Thierry; Méjean, Arnaud

doi:10.1016/s1166-7087(08)74567-6

Cited by 13 publications

(9 citation statements)

References 94 publications

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“…Secondary testicular lesions typically originate from, in order of frequency, lymphoma, acute leukemia, prostate, lung, kidney, melanoma, colon tumors, and esophageal cancer [1,5]. In 15% of cases, both testicles are affected [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Gregorio¹,

Nollevaux²,

D’Hondt³

et al. 2017

Med Surg Urol

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Testicular metastases are rare in prostatic adenocarcinomas. The discovery is often fortuitous, and they are diagnosed with a histological examination. Metastasis is often confused with a primitive testicular tumor. We describe an 86-year-old patient with metastatic prostate adenocarcinoma that affected the left testis. The metastasis was discovered after Ablatherm ® treatment. A prostatic origin must be suspected in a patient over 50 years old with testicular metastasis. This study highlights the importance of clinicopathological investigation and immunohistochemistry in determining the etiopathogenesis of testicular masses.

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Section: Discussionmentioning

confidence: 99%

“…The most common site of prostate cancer metastasis is the bone, particularly bones in the axial skeleton and the proximal long bone, which account for more than 90% of distant metastases [1]. Metastases are also found regularly in visceral locations (lung, liver, adrenal glands) [2].…”

Section: Introductionmentioning

confidence: 99%

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Gregorio¹,

Nollevaux²,

D’Hondt³

et al. 2017

Med Surg Urol

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“…The most frequent localization is the bones with more than 90% of the long-term metastasis [1]. Several other localizations were reported including the small intestine (1 - 4%) and the caecum, but never the rectum.…”

Section: Discussionmentioning

confidence: 99%

“…Elective locations are bones. A recent review of the literature about metastatic locations of prostate cancer did not report any isolated rectal metastasis [1]. We describe a case of a 75 years old man who presented such a metastasis.…”

Section: Introductionmentioning

confidence: 87%

Rectal Metastasis of Prostate Cancer: About a Case

Venara¹,

Thibaudeau²,

Lebdai

et al. 2010

J Clin Med Res

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Prostate adenocarcinomas present a high risk of metastasis. We report a case of an atypical prostate cancer metastasis. A male patient presented a prostatic adenocarcinoma treated by surgery. A biological recurrence was discovered during the follow-up by an increased rate of Prostate Specific Antigen (PSA) and was treated by hormonotherapy. Several months later, there was a re-increase of the PSA rate. The CT scan showed a radiation proctitis aspect. An intermittent hormonotherapy was decided. Six months later, he presented abdominal pain. Examinations were performed and showed a rectal carcinosarcoma with prostate origins. A surgical management was realised. The outcomes were an early recurrence. A symptomatic treatment was decided. There are not any rectal localisations reported in the literature. Only loco-regional invasions of the rectum are described and no histological modification of metastasis compared to the primitive tumor has been reported. So, we report a metastasis of a prostate adenocarcinoma which transformed into a carcinosarcoma.KeywordsAdenocarcinoma; Carcinosarcoma; Metastasis; Prostate; Rectal neoplasm

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“…There is a thick capsule (Denonvilliers’ fascia) between the prostate and rectal wall [12], and prostate cancer accompanied by rectal invasion is rare [13, 14]. In the present study, we retrospectively analyzed 9504 cases diagnosed as rectal cancer in our hospital from 2003 to 2015, and report the clinicopathological characteristics of 9 cases of prostate cancer with rectal wall invasion misdiagnosed as rectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological study of 9 cases of prostate cancer involving the rectal wall

et al. 2017

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BackgroundProstate cancer involving the rectal wall is rare and may lead to diagnostic pitfalls.Case presentationOut of 9504 patients with rectal tumors between January 2003 and January 2015, 9 patients (elderly with a mean age of 74 years) with prostate cancer involving the rectal wall were clinically misdiagnosed with rectal cancer. The lesions were located in the rectum, and included 3 circumferential rectal masses, 1 ulceration lesion, 1 crater-like mass, and 4 protruding lesions. Specimens were acquired using biopsy, fine needle aspiration, or resection. The initial symptoms of these patients included rectal urgency, bowel obstruction, and lower gastrointestinal bleeding. Prostate-related symptoms were not obvious. Histologically, 2 cases showed cancer cell invasion in the mucosa, 1 showed transmural invasion from the mucosa to subserosal soft tissues, and 7 cases had submucosa and muscularis propria involvement. All the 9 cases had muscularis propria involvement. However, there were no intraepithelial neoplasias in the mucosal layer, which is reminiscent of rectal carcinoma. The tumors consisted of small-sized or foamy cells that formed acinus-like, duct-like, and cribriform-like structures. We conducted histological staining and an immunohistochemical analysis for CDX-2, prostate-specific antigen (PSA), P504s, villin, carcinoembryonic antigen, CK-pan, cytokeratin 20, and Ki-67. All tumors were PSA and CK-pan positive, 5 of 9 tumors were P504s-positive, and all tumors were negative for the other markers. All patients underwent standard therapy for prostate cancer after the definitive pathological diagnosis. As of March 31, 2015, 8 patients were alive and 1 had died of prostate cancer 6 months posttreatment.ConclusionsAdenocarcinoma appearing in the rectal wall is not always rectal carcinoma. It is necessary to perform a differential diagnosis for prostate cancer in cases of rectal malignant tumors in elderly male patients. Any treatment should be postponed until the final definitive diagnosis is reached.

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Les sites métastatiques atypiques des cancers de la prostate

Cited by 13 publications

References 94 publications

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

Rectal Metastasis of Prostate Cancer: About a Case

Clinicopathological study of 9 cases of prostate cancer involving the rectal wall

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