Les réactions d’hypersensibilité aux médicaments anti-infectieux

Ponvert, C.

doi:10.1016/j.reval.2020.01.002

Cited by 1 publication

(3 citation statements)

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“…In a study from France, 9.4% of patients stated they were allergic to penicillin (17). In 7 -15% of children there is a suspected allergic/hypersensitivity (HS) reaction to drugs, especially antibiotics (18). In Great Britain, based on a study on medi cal records of 2.3 million of adult patients the prevalence to penicillin allergy is at 5.9%, more frequently in older patients, fe males and patients with co-morbidities as stated by their GPs (14).…”

Section: Discussionmentioning

confidence: 99%

“…Most children who report an allergy to a multi-class drug or a family of antibiotics are not allergic to these drugs. In these chil dren, one would think of allergic or non allergic intolerance or hypersensitivity to other drugs, often given in addition to anti biotics (non-opioid analgesics, antipyretics and non-steroidal anti-inflammatory drugs in particular) (18). "Verification of the penicillin allergy in hospitalized patients might restrict the use of reserve antibiotics and improve patient outcome" (15).…”

Section: Discussionmentioning

confidence: 99%

“…oral challenge testing) would allow more people to be prescribed first-line anti biotics, potentially improving health outcomes" (14). "Seven to 15% of children re port suspected allergic/hypersensitivity (HS) reactions to drugs, antibiotics espe cially, but studies based on clinical history, skin tests (ST) and drug challenge/ provocation tests (DPT) have shown that only 10-15% of these children were truly allergic, except for the children reporting immediate and/or severe reactions" (18). About 10% of the population reports an al lergy to penicillin, but after testing, up to 90% of these patients do not have an al lergy to penicillin (24).…”

Section: Discussionmentioning

confidence: 99%

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Self-reported allergy to parenterally administered penicillin

Ljubisavljević¹,

Živanović²

2020

ABC - čas urg medicine

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Introduction: Penicillin and penicillin products are in use in everyday medical practice. The most frequently reported adverse drug reactions are those to penicillin. New penicillin allergies occur more often with parenteral than oral treatment. In patients who are allergic to penicillin, prescribed therapy is more often the one of antibiotics of broad spectrum, and this therapy is more expensive. The allergies to penicillin are immunologically mediated. Scope of Study: to present patients' self-reported allergy to penicillin and report on types of adverse reactions following the parenteral administration of penicillin. Methodology: Retrospective study of the work of one physician in the City Institute for EMS Belgrade in the period from 2017 to 2018 involving 2481 patients. Results: There were 242 patients who reported they were allergic to penicillin, of which 160 were able to explain what happened after they were given parenteral penicillin. The cohort group was between 18-85 years old, average age 49.64 ± 17.24, while 65% of them were females. Most frequently reported adverse reactions were rash, redness and itching of the skin, loss of consciousness, swelling of the face, mouth, arms or body in general. Serious reactions have been reported in about 40% of cases. Conclusion: There is a large percentage of self-reported allergies to penicillin, and only a small number of those who experienced serious adverse reactions: swelling, unconsciousness, coma or shock.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%