Les Précipitines sériques dans les Bilharzioses humaines et expérimentales à <i>Schistosoma mansoni, S. haematobium et S japonicum</i>

Caprón, A; Vernes, A; Biguet, J.; Rose, F. De; Clay, A; Adenis, L

doi:10.1051/parasite/1966412123

Cited by 30 publications

(7 citation statements)

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“…Furthermore, an antigenic analysis of male and female worms has also shown no differences (28) although another report has identified gender-specific and pair-dependent glycoprotein antigens (29). Atkinson and Atkinson (30) also reported a protein that appeared to be synthesized in males and transferred to females; however, these results could not be substantiated (31).…”

Section: (Upper)mentioning

confidence: 59%

“…Once the skin is penetrated, the transformed parasite, termed a schistosomule, remains in the interstitial tissue for 2 days, then enters the circulation, and migrates to the lungs. By day [7][8][9][10][11][12][13][14] the parasites leave the lungs and migrate to the liver where male and female worms mate (approximately day 28), and encopula move to their final niche in the mesenteries. Egg laying commences about day 35 (1).…”

mentioning

confidence: 99%

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Characterization of a female-specific cDNA derived from a developmentally regulated mRNA in the human blood fluke Schistosoma mansoni.

Bobek

Rekosh

Keulen

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

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We have isolated and characterized a cDNA clone that is derived from a developmentally regulated mRNA found only in mature female schistosomes. The mRNA is approximately 950 nucleotides in length and is not detectable in immature female schistosomes isolated from single-sex infections, in male worms, or in eggs. During normal bisexual infections, the mRNA species is first detected 28 days after infection (the time of worm pairing) and increases to a high level 35 days after infection, coinciding with the start of egg production. The nucleotide sequence of the cDNA shows two large open reading frames in the coding strand. Several features of the clone, including the deduced sequence of the polypeptide encoded by one of the reading frames, suggest a relationship to the silk moth chorion (egg shell) gene family.The isolation of this clone provides us with a probe for further studies of female schistosome development and is a first step toward a detailed understanding of this process at the molecular level.Schistosomes are multicellular parasites whose life cycle includes both human and snail hosts. Schistosoma mansoni, as the other species that infect humans, inhabits the bloodstream of man. Infection begins when cercariae penetrate unbroken skin of humans who are in contact with fresh water containing Schistosoma. Once the skin is penetrated, the transformed parasite, termed a schistosomule, remains in the interstitial tissue for 2 days, then enters the circulation, and migrates to the lungs. By day 7-14 the parasites leave the lungs and migrate to the liver where male and female worms mate (approximately day 28), and encopula move to their final niche in the mesenteries. Egg laying commences about day 35 (1).Unlike most trematode parasites, schistosomes are dioecious. S. mansoni has 8 pairs of chromosomes, and the female schistosome is heterogametic (2). Sex is determined in the zygote, which develops into an embryonated egg.Earlier studies dealing with female maturation and development demonstrated that the presence of the male worm is necessary for full growth and complete sexual maturation of the female (3, 4). Female worms obtained from single-sex infections are stunted and not sexually developed (3, 5), although male worms from single-sex infections appear normal (6, 7). Moreover, Clough (8) showed that male worms are necessary to maintain, as well as to initiate, female maturation and fecundity. When sexually mature female worms are removed from their male partners, they stop laying eggs and regress to a condition morphologically resembling immature female parasites, until they are reunited with mature male worms. The stimulus from the male schistosome responsible for female growth, maturation, and fecundity is independent of sperm transfer (6, 7, 9), but its exact nature is unresolved (4, 10-12).The unusual interplay between male and female schistosomes in the regulation of female development provides a unique system to study sexual differentiation. Moreover, since the production of eggs by mature ...

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Section: (Upper)mentioning

confidence: 59%

mentioning

confidence: 99%

Characterization of a female-specific cDNA derived from a developmentally regulated mRNA in the human blood fluke Schistosoma mansoni.

Bobek

Rekosh

Keulen

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

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“…In the immuno-electrophoresis (IEP) test, as developed by Chordi and Kagan (1965) and modified by Capron et al (1967), a positive sample gives a particular precipitation arc, designated 'arc 5', that is thought to be a specific indication of E. granulosus infection. The double-diffusion assay originally described by Coltorti and Varela-Diaz (1978), DD5, relies on the specific detection of antibodies to the antigen that produces arc 5, which is itself now known as 'arc 5' or 'antigen 5'.…”

Section: Serodiagnosis Of Human Echinococcosismentioning

confidence: 99%

Echinococcosis: historical landmarks and progress in research and control

Moro

Schantz

2006

Annals of Tropical Medicine & Parasitology

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Although hydatid cysts were recognised and described in ancient times, in both livestock and humans, it was not until the 17th Century that their biological nature began to be understood. The past 50 years have seen a veritable revolution in knowledge and technology applicable to the biology of the cestodes and the diseases they cause. The parasites that form hydatid cysts belong to the genus Echinococcus, which is now recognized as a complex of closely related cestode parasites adapted to a variety of host-assemblages linked by predator-prey relationships. Synanthropic transmission in dogs and domestic livestock greatly increases the possibilities of zoonotic transmission, and the highest prevalences of Echinococcus infection in humans therefore occur in populations engaged in livestock rearing in which domestic dogs have access to the viscera of the livestock that serve as intermediate hosts. The application of modern scientific technology over the last few decades has not only revealed the diversity of host-parasite relationships within the genus Echinococcus but also led to greatly improved technology for the diagnosis and treatment of the echinococcoses in humans and lower animals. Although control programmes have led to marked reductions in transmission in certain geographical and socio-political settings, transmission and the resultant diseases continue unabated throughout most of the parasites' world-wide distribution.

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“…Of note, Capron et al (1965) demonstrated common antigens in adults, eggs and cercariae of Schistosoma mansoni. Capron et al (1966) showed also that di#erent species of Schistosoma shared common antigens. These authors further demonstrated that di#erent trematode genera had similar antigenic profiles (Capron et al, 1968).…”

Section: Discussionmentioning

confidence: 96%

Reactions of sera from immunised and experimentally infected thick-lipped grey mullet,Chelon labrosus(Risso, 1826), with isolated proteins ofCryptocotyle lingua(Creplin, 1825)

Wood

Matthews

1996

Fish & Shellfish Immunology

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Les Précipitines sériques dans les Bilharzioses humaines et expérimentales à Schistosoma mansoni, S. haematobium et S japonicum

Cited by 30 publications

References 0 publications

Characterization of a female-specific cDNA derived from a developmentally regulated mRNA in the human blood fluke Schistosoma mansoni.

Characterization of a female-specific cDNA derived from a developmentally regulated mRNA in the human blood fluke Schistosoma mansoni.

Echinococcosis: historical landmarks and progress in research and control

Reactions of sera from immunised and experimentally infected thick-lipped grey mullet,Chelon labrosus(Risso, 1826), with isolated proteins ofCryptocotyle lingua(Creplin, 1825)

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