Les nanoparticules polymères pour la délivrance de principes actifs anticancéreux

Nicolas, Julien; Couvreur, Patrick

doi:10.1051/medsci/20173301003

Cited by 13 publications

(4 citation statements)

References 51 publications

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“…Maltodextrins are abundant in nature, and nanoparticles issued from this polymer are also deemed biocompatible and biodegradable. Their derived forms have been extensively studied in many applications, such as the delivery of anticancer proteins [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Antibacterial Activity of Dermaseptin through Its Immobilization on Alginate Nanoparticles—Effects of Menthol and Lactic Acid on Its Potentialization

et al. 2022

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Dermaseptin B2 (DRS-B2) is an antimicrobial peptide secreted by Phyllomedusa bicolor, which is an Amazonian tree frog. Here, we show that the adsorption of DRS-B2 on alginate nanoparticles (Alg NPs) results in a formulation (Alg NPs + DRS-B2) with a remarkable antibacterial activity against Escherichia coli ATCC 8739 and E. coli 184 strains, which are sensitive and resistant, respectively, to colistin. The antibacterial activity, obtained with this new formulation, is higher than that obtained with DRS-B2 alone. Of note, the addition of lactic acid or menthol to this new formulation augments its antibacterial activity against the aforementioned Gram-negative bacilli. The safety of DRS-B2, and also that of the new formulation supplemented or not with a small molecule such as lactic acid or menthol has been proven on the human erythrocytes and the eukaryotic cell line types HT29 (human) and IPEC-1 (animal). Similarly, their stability was determined under the conditions mimicking the gastrointestinal tract with different conditions: pH, temperature, and the presence of digestive enzymes. Based on all the obtained data, we assume that these new formulations are promising and could be suggested, after in vivo approval and completing regulation aspects, as alternatives to antibiotics to fight infections caused by Gram-negative bacilli such as E. coli.

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Section: Discussionmentioning

confidence: 99%

Enhanced Antibacterial Activity of Dermaseptin through Its Immobilization on Alginate Nanoparticles—Effects of Menthol and Lactic Acid on Its Potentialization

et al. 2022

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“…Many of these works have given proofs of concepts of delivery methods based on the use of polymer nanoparticles. These works inspire current researches on treatments based on the use of nanotechnologies holding promise to treat resistant cancers [Friberg and Nyström, 2016, Li et al, 2017, Nicolas and Couvreur, 2017, Sobot et al, 2017, intracellular infections [Abed andCouveur, 2014, Jiang et al, 2018] metabolic diseases Bazile, 2016, Wong et al, 2017] and diseases of the central nervous system [Andrieux and Couvreur, 2013, Kreuter, 2014, Savaira et al, 2016.…”

Section: Bypassing the Cell Membrane Of Multidrug Resistant Cancer Cellsmentioning

confidence: 92%

A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

Vauthier

2019

Journal of Drug Targeting

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Starting in the late 1970s, the pioneering work of Patrick Couvreur gave birth to the first biodegradable nanoparticles composed of a biodegradable synthetic polymer. These nanoparticles, made of poly(alkylcyanoacrylate) (PACA), were the first synthetic polymer based nanoparticulate drug carriers undergoing a phase III clinical trial so far. Analyzing the journey from the birth of PACA nanoparticles to their clinical evaluation, the paper highlights their remarkable adaptability to bypass various drug delivery challenges found on the way. At present, PACA nanoparticles includes a wide range of nanoparticles that can associate drugs of different chemical nature and be administered in vivo by different routes. The most recent technologies giving the nanoparticles customized functions could also be implemented on this family of nanoparticles. Through different examples, the paper discusses the seminal role of the PACA nanoparticles' family in the development of nanomedicines.

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“…They have the advantages of higher EE and structural stability and can be endowed with more functions through International Journal of Nanomedicine 2023:18 https://doi.org/10.2147/IJN.S410688 DovePress 4287 Dovepress structural modification, so they have higher bioavailability and efficacy. 124,125 Numerous polymers, including poly (lactic-coglycolic acid) (PLGA) and chitosan, have been utilized to create nanoparticles. Lactic and glycolic acids are randomly polymerized to form PLGA, a biodegradable functional polymer organic molecule.…”

Section: Nanoparticle-based Cur Deliverymentioning

confidence: 99%

Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

Huang¹,

Zhai²,

Fan³

et al. 2023

IJN

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Breast cancer (BC) is the most prevalent type of cancer in the world and the main reason women die from cancer. Due to the significant side effects of conventional treatments such as chemotherapy and radiotherapy, the search for supplemental and alternative natural drugs with lower toxicity and side effects is of interest to researchers. Curcumin (CUR) is a natural polyphenol extracted from turmeric. Numerous studies have demonstrated that CUR is an effective anticancer drug that works by modifying different intracellular signaling pathways. CUR's therapeutic utility is severely constrained by its short half-life in vivo, low water solubility, poor stability, quick metabolism, low oral bioavailability, and potential for gastrointestinal discomfort with high oral doses. One of the most practical solutions to the aforementioned issues is the development of targeted drug delivery systems (TDDSs) based on nanomaterials. To improve drug targeting and efficacy and to serve as a reference for the development and use of CUR TDDSs in the clinical setting, this review describes the physicochemical properties and bioavailability of CUR and its mechanism of action on BC, with emphasis on recent studies on TDDSs for BC in combination with CUR, including passive TDDSs, active TDDSs and physicochemical TDDSs.

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Les nanoparticules polymères pour la délivrance de principes actifs anticancéreux

Cited by 13 publications

References 51 publications

Enhanced Antibacterial Activity of Dermaseptin through Its Immobilization on Alginate Nanoparticles—Effects of Menthol and Lactic Acid on Its Potentialization

Enhanced Antibacterial Activity of Dermaseptin through Its Immobilization on Alginate Nanoparticles—Effects of Menthol and Lactic Acid on Its Potentialization

A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles

Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

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