X-ray fluorescence (XRF) is a well-known technique for the analysis of ancient metals. Thanks to the availability of portable instruments (p-XRF), it is extensively used for the chemical characterization of coins directly in museums. In this work, the potentialities of the technique have been investigated, through its application to a case study concerning the Cisalpine Gaul coinage. More than two hundreds drachmas have been analysed to discriminate different productions on the base of minor elements. Major elements, on the other hand, have been used to trace alloy changes through the centuries. As concerns the quantification of the silver content (fineness), XRF and neutron diffraction results have been compared.