Les Moles Invasives :Presentations Cliniques Et Prise en Charge Therapeutique. (A Propos De2 Cas Et Revue De La Litterature)

Mohamed, Rahaoui; Zizi, H.; Mamouni, Nisrine; Errarhay, Sanaa; Bouchikhi, C.; Banani, Abdelaziz; Haloua, Meriem; Boubbou, Mohammed Amine; Maâroufi, Mohamed

doi:10.21474/ijar01/10607

Cited by 2 publications

(7 citation statements)

References 24 publications

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“…Hydatidiform mole is a benign tumor with malignant potential [5]. The risk of progression to invasion is greater in multiparous patients than in those with a history of spontaneous abortion or an anterior mole [6].…”

Section: Discussionmentioning

confidence: 99%

“…The first case was described by Rajaonera [3] in 1965 and the main differential diagnosis mentioned was then choriocarcinoma [3]. Indeed, choriocarcinomas differ from invasive moles by the presence of chorionic villi [5]. The second case, described by Rabarikoto in 2018 [4], was observed at the complication stage with acute abdominal pain, significant metrorrhagia, and cardiovascular collapse in the context of uterine perforation 2.5 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

“…Spontaneous presentation of an invasive mole is extremely rare, and it is preceded by a hydatidiform mole in approximately 95% of cases, with a usual interval of less than 6 months between presentation of the case and diagnosis of molar invasion [5]. In the 2 observations of Rahaoui, the invasive mole progressed after the evacuation of the complete mole with intervals of 3 months and 3 years [5].…”

Section: Discussionmentioning

confidence: 99%

“…An invasive mole is a form of gestational trophoblastic neoplasia (GTN) that results from abnormal proliferation of the placental trophoblast. Generally, NTGs appear when the mechanisms for the regulation of proliferation control and trophoblastic invasion are lost [5].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasound is the gold standard for the diagnosis of invasive mole [5]. B-mode ultrasound is useful for detecting the presence of an abnormal uterine mass.…”

Section: Discussionmentioning

confidence: 99%

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Invasive Mole of the Uterus: A Case Report

Razafindrafara¹,

Raivoherivony²,

Vahatra³

et al. 2022

OJPathology

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Invasive mole is a rare subgroup of gestational trophoblastic disease characterized by the invasion of molar tissue into the myometrium or uterine vasculature. In this paper, we report the third case of invasive mole described in the Malagasy literature. A 33-year-old woman was referred to the Soavinandriana Hospital, her complaint was persistent vaginal bleeding during 2 months, occurring at 3 months of pregnancy with biological anemia without hemodynamic repercussions. The human chorionic gonadotropin (HCG) level was 385,931 mIU/ml. A haemostasis hysterectomy was performed. Histological examination showed an enlarged uterus and endometrial cavity containing edematous chorionic villi with trophoblastic proliferation invading the myometrium. The diagnosis was an invasive mole, stage I, FIGO score 6. Chemotherapy was prescribed but was not honored. After 45 days of follow-up, the serum βHCG level decreased to 1803 mIU/ml, without clinical symptoms. The patient then lost sight. Persistent vaginal bleeding after pregnancy may be the only clinical symptom of an invasive mole and should raise suspicion. Histological examination establishes the diagnosis. As this is an unusual cause of vaginal bleeding, our case should remind physicians that when faced with this symptom, the possibility of an invasive mole should be considered in order to make an early diagnosis for less aggressive treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Ultrasound is the gold standard for the diagnosis of invasive mole [5]. B-mode ultrasound is useful for detecting the presence of an abnormal uterine mass.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Invasive Mole of the Uterus: A Case Report

Razafindrafara¹,

Raivoherivony²,

Vahatra³

et al. 2022

OJPathology

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Invasive Mole Mimicking Abnormal Uterine Bleeding: A Case Report

Sankhe¹,

Somalwar²,

Jiandani³

et al. 2023

Cureus

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Invasive mole (IM) is a very uncommon subtype of gestational trophoblastic disease (GTD), which is the invasion of molar tissue into the uterine or myometrial vasculature. However, this report presents a rare case of a 41-year-old female multiparous P7 with five full-term normal vaginal deliveries and two preterm normal vaginal deliveries. As the patient was not using contraception, her urine pregnancy test (UPT) was done, which demonstrated positive results. A speculum examination revealed a healthy cervix with just mild bleeding, whereas a vaginal examination revealed a firm cervix and an anteverted and mobile eight-weekold uterus along with a free fornix. Pelvic ultrasound and magnetic resonance imaging (MRI) demonstrated the diagnosis of GTD, for which consultation from an oncology physician was taken and the treatment proceeded with a total abdominal hysterectomy. Histological examination of the uterus showed a circumscribed nodule showing a large area of hemorrhage with few chorionic villi lined with trophoblastic cells and occasional villi invading the myometrium and endometrial cavity suggesting hydatidiform mole showing early invasion that confirmed the diagnosis of IM. In conclusion, reproductive-age women who experience abnormal uterine bleeding (AUB) should suspect pregnancy with several possible complications, for which a pregnancy test should be done to rule out complications.

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Les Moles Invasives :Presentations Cliniques Et Prise en Charge Therapeutique. (A Propos De2 Cas Et Revue De La Litterature)

Cited by 2 publications

References 24 publications

Invasive Mole of the Uterus: A Case Report

Invasive Mole of the Uterus: A Case Report

Invasive Mole Mimicking Abnormal Uterine Bleeding: A Case Report

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