Les môles hydatiformes complètes au Maroc : étude épidémiologique et clinique

Boufettal, Houssine; Coullin, Philippe; Mahdaoui, Sakher; Noun, M.; Hermas, S.; Samouh, N.

doi:10.1016/j.jgyn.2011.02.008

Cited by 25 publications

(36 citation statements)

References 70 publications

(170 reference statements)

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“…This pattern was reported by Khabouze et al and Boufettal et al in Morocco [6, 7] but also worldwide, as published in the research of Parazzini et al in Italy; Abboud et al in France; Kuyumcuoglu et al in Turkey; Karimi-Zarchi et al in Iran; and Mourali et al in Tunisia [15–19], and confirms young age and nulliparity as major risk factors of the disease. These studies also found a low socioeconomic status for most affected patients.…”

Section: Discussionsupporting

confidence: 83%

“…These studies also found a low socioeconomic status for most affected patients. This is particularly striking in the Moroccan context, where a low socioeconomic status was reported for over 80% of patients, including those in our study [6, 7]. Analysis of our patients' geographic origin found a large majority from Salé , a city often described as a “poverty pocket” in the region of Rabat-Salé-Zemmour-Zaërs , with over 20% of its population living under the poverty line, further confirming the low socioeconomic status pattern of GTD patients.…”

Section: Discussionmentioning

confidence: 63%

“…In the rest of Morocco, little data is available on GTD. In the neighboring Great Casablanca region, Boufettal et al reported an incidence of 4.2 cases per 1000 deliveries at the Ibn Rochd University Hospital between 2000 and 2009, close to twofold our incidence [7]. Bearing in mind Khabouze argument, making any interpretation or comparison difficult, interhospital incidence variations could probably be attributed to differences in patient's fluxes and referral management systems adopted by each regional center.…”

Section: Discussionmentioning

confidence: 90%

See 2 more Smart Citations

Implementation and Monitoring of a Gestational Trophoblastic Disease Management Program in a Tertiary Hospital in Morocco: Opportunities and Challenges

Khachani

Alami

Bezad

2017

Obstetrics and Gynecology International

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Objective. Gestational Trophoblastic Disease (GTD) management requires clear guidelines for diagnosis, treatment, and follow-up. Unequal management skills among practitioners, inadequate treatment, irregular surveillance, and drop-out are common in resource-limited settings and can lead to life-threatening complications and morbidities. To address these challenges, we implemented a GTD Management Program at the National Center for Reproductive Health in Rabat, Morocco. Methods and Program Description. In-depth review of management protocols was carried out, and concise guidelines were developed, with targeted training for physicians. A physical space and a weekly fixed GTD consultation were set, and personalized follow-up was established for each patient. An electronic database documenting patients' surveillance was created, allowing immediate outreach in case of irregularities. Results. During the period from October 2013 to June 2016, 50 patients were included in this program. Patients' mean age was 33 years; 92% were illiterate and 82% had a low socioeconomic status. 68% had a positive evolution, while 32% developed gestational trophoblastic neoplasia, requiring 2 to 6 chemotherapy sessions. An average of 2.8 outreach reminders were necessary for each patient. 94% fully adhered to the program of care and completed properly their follow-up. Conclusion. Implementation and thorough monitoring of this program helped optimize patients' care, avoiding drop-outs and delays in diagnosing and treating complications.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 90%

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Implementation and Monitoring of a Gestational Trophoblastic Disease Management Program in a Tertiary Hospital in Morocco: Opportunities and Challenges

Khachani

Alami

Bezad

2017

Obstetrics and Gynecology International

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“…La médicalisation de la naissance en France s'est développée progressivement depuis 1952, période où une femme sur deux était suivie médicalement, jusqu'aux années 1968/1970. Depuis cette date, environ 100 % des femmes ont un suivi [18], permettant un diagnostic précoce et un traitement rapide. Notons que, dans de rares cas, la patiente peut expulser spontanément la môle hydatiforme complète [9].…”

Section: Les Hypothèses Explicatives Hypothèses Historiquesunclassified

La môle hydatiforme complète

Candelier

2015

Med Sci (Paris)

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“…In Western countries, studies by several groups from various countries have shown that 1 % to 2 % of patients with a prior mole have a second one [5, 13, 14]. However, higher frequencies of RHMs are reported from the Middle and Far East; in these regions, the frequency of RHMs ranges from 2.5 % up to 9.4 % [6, 15–18]. In rare cases, RHMs have been seen in related women from the same family, and these cases are termed familial cases of RHMs.…”

Section: Introductionmentioning

confidence: 99%

Genetics and Epigenetics of Recurrent Hydatidiform Moles: Basic Science and Genetic Counselling

Nguyen

Slim

2014

Curr Obstet Gynecol Rep

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Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal hyperproliferation of trophoblastic cells, which derive from the trophectoderm, the outer layer of the blastocyst that would normally develop into the placenta during pregnancy. GTDs encompass hydatidiform mole (HM) (complete and partial), invasive mole, gestational choriocarcinoma, placental-site trophoblastic tumor, and epithelioid trophoblastic tumor. Of these, the most common is HM, and it is the only one that has been reported to recur in the same patients from independent pregnancies, which indicates the patients’ genetic predisposition. In addition, HM is the only GTD that segregates in families according to Mendel’s laws of heredity, which made it possible to use rare familial cases of recurrent HMs (RHMs) to identify two maternal-effect genes, NLRP7 and KHDC3L, responsible for this condition. Here, we recapitulate current knowledge about RHMs and conclude with the role and benefits of testing patients for mutations in the known genes.

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Les môles hydatiformes complètes au Maroc : étude épidémiologique et clinique

Cited by 25 publications

References 70 publications

Implementation and Monitoring of a Gestational Trophoblastic Disease Management Program in a Tertiary Hospital in Morocco: Opportunities and Challenges

Implementation and Monitoring of a Gestational Trophoblastic Disease Management Program in a Tertiary Hospital in Morocco: Opportunities and Challenges

La môle hydatiforme complète

Genetics and Epigenetics of Recurrent Hydatidiform Moles: Basic Science and Genetic Counselling

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