Flame ignition, stabilization and extinction or pollutant predictions are crucial issues in Large Eddy Simulations (LES) of turbulent combustion. These phenomena are strongly influenced by complex chemical effects. Unfortunately, despite the rapid increase in computational power, performing turbulent simulations of industrial configurations including detailed chemical mechanisms will still remain out of reach for a long time. This article proposes a review of commonly-used approaches to address fluid/chemistry interactions at a reduced computational cost. Several chemistry modeling routes are first examined with a focus on tabulated chemistry techniques. The problem of coupling chemistry with LES is considered in a second step. Examples of turbulent combustion simulations are presented in the final part of the article. Three LES applications are analyzed: a lean swirled combustor, a non-adiabatic turbulent stratified flame and a combustion chamber where internal recirculations promote the dilution of fresh gases by burnt gases. Keywords Turbulent combustion • Large Eddy Simulation • Tabulated chemistry • Complex chemistry 1 Introduction Combustion accounts for about 90 % of the global consumption of primary energy [1]. Despite its environmental impact this share will probably not fall in the near future. Combustion delivers energy which is immediately available through the exothermic conversion of gaseous, liquid or solid fuels. There are no other way to provide energy which are as convenient and as effective. In automotive or aerospace applications, combustion provides