Les kératites fongiques dans la région de Tunis: caractéristiques épidémiologiques, modalités diagnostiques et thérapeutiques

Anane, S.; Ayed, N. Ben; Malek, Ines; Chebbi, A.; Lejri, Samir; Bouguila, H.; Kaouech, E.; Belhadj, S.; Kallel, K.; Ayed, Sayda; Chaker, E.

doi:10.1684/abc.2008.0452

Cited by 3 publications

(1 citation statement)

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“…Despite ophthalmologists' best efforts, medical treatment fails in 15–36% of cases ( 6 , 28 ). When this occurs, therapeutic keratoplasty is necessary ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Full-thickness conjunctival flap covering surgery combined with amniotic membrane transplantation for severe fungal keratitis

Zhong

Wang

et al. 2018

Exp Ther Med

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Fungal keratitis is a severe and common ocular infectious disease. The present study evaluated the efficiency of full-thickness conjunctival flap covering surgery with amniotic membrane transplantation (FCCS + AMT) as a transitional surgery for severe fungal keratitis. A total of 17 patients with severe fungal keratitis without corneal perforation underwent FCCS + AMT between January 2010 and December 2015. The pathogenic factors, preoperative diagnosis and postoperative prognosis of FCCS + AMT at 3 months were evaluated. Subsequently, 7 patients received sclerokeratoplasty, and the best-corrected visual acuity (BCVA) and recurrence ratio were analyzed at 1 month postoperatively. The primary risk factor was agricultural trauma (7 cases), followed by a non-agricultural object entering the eye (3 cases). Preoperatively, there were 10 cases of fungal keratitis positively identified using confocal microscopy and 9 cases positively identified by corneal scrapings. A total of 3 months following FCCS + AMT, the percentage of cases resulting in preservation of the eyeball was 88.24%, with 15/17 patients demonstrating complete conjunctival re-epithelization and a smooth conjunctival surface without any complications. A total of 2 (11.76%) patients experienced melting of the conjunctival flap and development of endophthalmitis, and subsequently underwent ocular evisceration surgery. A total of 7 patients underwent sclerokeratoplasty and the mean logarithm of the minimum angle of resolution BCVA at 1 month was significantly improved (0.689±0.121; P<0.001) compared with preoperative values (2.459±0.037) and BCVA values following FCCS + AMT (2.529±0.066). No recurrence was observed in any of the cases during the follow-up period. Conclusively, FCCS + AMT may be a preferable treatment for severe fungal keratitis of the entire corneal ulcer without perforation, and may save the eyeball and provide a greater opportunity for corneal transplantation.

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“…Despite ophthalmologists' best efforts, medical treatment fails in 15–36% of cases ( 6 , 28 ). When this occurs, therapeutic keratoplasty is necessary ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Full-thickness conjunctival flap covering surgery combined with amniotic membrane transplantation for severe fungal keratitis

Zhong

Wang

et al. 2018

Exp Ther Med

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Determination and Prevalence of Bacterial and Fungal Keratitis among Patients in Baghdad City

Khalil¹,

Hadi²,

Kamil³

2018

J Pure Appl Microbiol

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Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis

Wang

Yan

Chen

et al. 2022

J. Microbiol. Biotechnol.

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Fungal keratitis is a refractory kind of keratopathy. We attempted to investigate the anti-inflammatory role of thymol on Aspergillus fumigatus ( A. fumigatus ) keratitis. Wound healing and fluorescein staining of the cornea were applied to verify thymol’s safety. Mice models of A. fumigatus keratitis underwent subconjunctival injection of thymol. The anti-inflammatory roles of thymol were verified by hematoxylin-eosin (HE) staining, slit lamp observation, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting. In contrast with the DMSO group, more transparent corneas and less inflammatory cells infiltration were detected in mice treated with 50 μg/ml thymol. Thymol downregulated the synthesis of TLR4, MyD88, NF-kB, IL-1β, NLRP3, caspase 1, caspase 8, GSDMD, RIPK3 and MLKL. In summary, we proved that thymol played a protective part in A. fumigatus keratitis by cutting down inflammatory cells aggregation, downregulating the TLR4/ MyD88/ NF-kB/ IL-1β signal expression and reducing necroptosis and pyroptosis.

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Les kératites fongiques dans la région de Tunis: caractéristiques épidémiologiques, modalités diagnostiques et thérapeutiques

Cited by 3 publications

References 0 publications

Full-thickness conjunctival flap covering surgery combined with amniotic membrane transplantation for severe fungal keratitis

Full-thickness conjunctival flap covering surgery combined with amniotic membrane transplantation for severe fungal keratitis

Determination and Prevalence of Bacterial and Fungal Keratitis among Patients in Baghdad City

Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis

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